All of the evidence provided on Hippocampome.org are quotes from scientific texts.
However, because quoted passages may be difficult to understand in isolation, contextual information and expanded abbreviations set in square brackets have been added for clarity.
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EXPRESSION: positive
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p2, Fig. 1
Linking PMID: 21256930 Linking Quote: Principal neurons identified by the presence of their somata in the principal cell layer, which is densely packed with and nearly homogeneous for the somata of the subregion's principal neurons (Czeh et al., 2013, Acta Biologica Hungarica).
"Figure 1. Subcellular localization of CaM [Calmodulin] and Ng [neurogranin] in the pyramidal neurons of hippocampal CA1 region and subiculum Control tissue sections were examined with 100x objectives for CaM (Alexa 594) and Ng (FITC) of cells in the CA1 region (A-C) and subiculum (D-F). Positive staining of CaM of the CA1 pyramidal neurons (Py) was largely confined to the nucleus (A), whereas Ngpositive staining was evident in the nucleus, cytoplasm, and apical dendrites (B) within stratum radiatum (Sr). The merged images (C) showed prominent co-localization of CaM and Ng in the nucleus, which was surrounded by a ring of cytoplasmic Ng. In contrast, pyramidal neurons in the subiculum exhibit uniform co-localization of both CaM and Ng in the nucleus, cytoplasm, and apical dendrites (D-F)."
EXPRESSION: positive
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p225, right bottom
Linking PMID: 21516261 Linking Quote: Principal neurons identified by the presence of their somata in the principal cell layer, which is densely packed with and nearly homogeneous for the somata of the subregion's principal neurons (Czeh et al., 2013, Acta Biologica Hungarica).
"In hippocampus, Ng [neurogranin] and CaM [calmodulin] were colocalized in all principle neurons at the various subfields. Under the basal conditions, these proteins exhibited higher concentrations in soma than in dendrites with the exception of pyramidal neurons in subiculum complex, which exhibited a uniform distribution of both Ng and CaM in all cellular compartments (data not shown)."
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