negative inference; confirmed by additional inferences
All of the evidence provided on Hippocampome.org are quotes from scientific texts.
However, because quoted passages may be difficult to understand in isolation, contextual information and expanded abbreviations set in square brackets have been added for clarity.
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EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p1806, right middle
"All PV[parvalbumin]+ neurons [in CA3 and CA1] were positive for the GABA[gamma aminobutyric acid]A receptor [alpha]1 subunit [reference 31] (Fig._5b-d)."
Interpretation notes: Glutamatergic and GABAergic GABAa alpha1- types in CA1 SLM_SR_SP_SO are probably PV- by contrapositive logic
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p555, table 3
"TABLE 3. Distribution of 1 and 2 Adrenergic Receptor Expression in Interneurons in the Adult Rat Hippocampus"
Interpretation notes: Glutamatergic and GABAergic AR-beta1- types in CA1 SR are probably PV- by contrapositive logic; (n = 1/1)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p200, right mid
"In all layers, PV[parvalbumin]-IR[immunoreactivity] and VIP[vasoactive intestinal polypeptide]-IR were never found in the same cell. Accordingly, cells double-labeled for mGluR[metabotropic glutamate receptor]1alpha and VIP in all cases lacked detectable levels of immunofluorescent signal for PV (Fig. 9)."
Interpretation notes: Glutamatergic and GABAergic VIP+ types in CA1 SLM_SR_SP_SO are probably PV- by contrapositive logic
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p971, left mid
"Parvalbumin-immunoreactive neurons were seen in strata oriens and pyramidale, but not in strata radiatum and lacunosum-moleculare of the CA1 and CA3, while parvalbumin-immunoreactive fibers were found in all strata, but more concentrated in the stratum pyramidale."
Interpretation notes: Glutamatergic and GABAergic types in CA1 SLM_SR are negative for PV
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p 311, right bottom
"In the case of parvalbumin-VIP [vasoactive intestinal polypeptide] co-localization, only those VIP cells within or close to stratum pyramidale were examined, since parvalbumin cells are absent in other layers. Thus, all VIP-positive cells in the distal part of stratum radiatum or in stratum lacunosum-moleculare are considered parvalbumin-negative by their position. None of the 136 VIP-immunopositive cells near stratum pyramidale in CA1 and the 36 in CA3 showed parvalbumin immunofluorescence (Fig. 8E, F). In addition, 15 large multipolar VIPpositive basket cells were selected from different sections, but those were also negative for parvalbumin. This finding demonstrates that there is a basket cell type different from those containing parvalbumin but which is characterized by the coexistence of VIP and CCK [cholecystokinin]."
Interpretation notes: Glutamatergic and GABAergic types in CA1 SLM_SR are negative for PV
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p 311, right bottom
"In the case of parvalbumin-VIP [vasoactive intestinal polypeptide] co-localization, only those VIP cells within or close to stratum pyramidale were examined, since parvalbumin cells are absent in other layers. Thus, all VIP-positive cells in the distal part of stratum radiatum or in stratum lacunosum-moleculare are considered parvalbumin-negative by their position. None of the 136 VIP-immunopositive cells near stratum pyramidale in CA1 and the 36 in CA3 showed parvalbumin immunofluorescence (Fig. 8E, F). In addition, 15 large multipolar VIPpositive basket cells were selected from different sections, but those were also negative for parvalbumin. This finding demonstrates that there is a basket cell type different from those containing parvalbumin but which is characterized by the coexistence of VIP and CCK [cholecystokinin]."
Interpretation notes: Glutamatergic and GABAergic VIP+ types in CA1 SLM_SR_SP_SO are probably PV-; Clopper-Pearson confidence interval lower bound = 97.3% (n = 136/136)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p396, right bottom
"Stratum radiatum contains no PV[parvalbumin]-positive cells; thus, CCK[cholecystokinin]-immunoreactive basket cells are PV negative
(Gulyas et al., 1991b). Direct evidence for two neurochemically
distinct types of basket cells has recently been provided (Acsady
et al., 1996a,b; see Section IV.3.d)."
Interpretation notes: Glutamatergic and GABAergic types in CA1 SR are negative for PV
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p841, Table 2
"TABLE 2. Proportion of neurons stained for GABA, calcium-binding proteins
and neuropeptides expressing the a1 subunit-immunoreactivity "
Interpretation notes: Glutamatergic and GABAergic GABAa alpha1- types in CA1 SLM_SR_SP_SO are probably PV- by contrapositive logic
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p36, Table 3
"Table 3. Number of calretinin- and/or parvalbumin-immunoreactive nonpyramidal cells "
Interpretation notes: Glutamatergic and GABAergic CR+ types in CA1 SR are probably PV-; Clopper-Pearson confidence interval lower bound = 91.4% (n = 41/41)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p36, Table 3
"Table 3. Number of calretinin- and/or parvalbumin-immunoreactive nonpyramidal cells "
Interpretation notes: Glutamatergic and GABAergic CR+ types in CA1 SR are probably PV- by contrapositive logic; Clopper-Pearson confidence interval lower bound = 85.2% (n = 23/23)
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negative inference; confirmed by additional inferences
