Neuron type - CA1 Interneuron Specific LMR-O*

		* indicates new v2.0 neuron type
Name		Supertype (ID:Family:Type:Subregion)
	CA1 (i)2201 Interneuron Specific LMR-O*	S091204:Interneuron Specific:IS:CA1

Name derivation

This cell is verified to preferentially target non-principal cells. Although more politically loaded, the phrase "interneuron specific" is more compact than "non-principal cell-specific" and is more commonly found in the cited literature. The modifier is a variant of "O-LM" because the dendrites are in SLM and SR and the axons project to SO. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
	CA1 IS3 cell

List of articles

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Tyan L (2014) J Neurosci

Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry.
Tyan L, Chamberland S, Magnin E, Camire O, Francavilla R, David LS, Deisseroth K, Topolnik L.
J Neurosci, 2014 Mar, 34 (13), Pages: 4534 - 4547
PMID: 24671999; DOI: 10.1523/JNEUROSCI.3813-13.2014
Tags: morphology, marker, synapse probabilities

List of Hippocampome.org to NeuroMorpho.Org mappings

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Topolnik

29-10-10-B (Fig 1F)
cell-pair-25-11-10-B_file2 (Fig 2A_black/red)

Morphology

Soma
	CA1:SR

Axons
	CA1:SO

Dendrites
	CA1:SLM
	CA1:SR

Representative figure

Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry.
Tyan L, Chamberland S, Magnin E, Camire O, Francavilla R, David LS, Deisseroth K, Topolnik L
J Neurosci, 2014 Mar, 34 (13), pages: 4534 - 4547
PMID: 24671999; DOI: 10.1523/JNEUROSCI.3813-13.2014

"Figure1. Identification of IS3 cells in the VIP-eGFP mouse model. ... F, Anatomical reconstruction (the axon is shown in red, the dendrites are shown in black) of an IS3 cell {CA1 Interneuron Specific LMR-O*} that was recorded and filled with biocytin in slices obtained from VIP-eGFP."

Molecular markers

Positive
	CR
	VIP

Negative
	AR-beta1 (inference)
	AR-beta2 (inference)
	CB (multiple confirming inferences)
	CB1 (multiple confirming inferences)
	CCK (confirmed by inference)
	Chrna2 (inference)
	GABAa\alpha 6 (inference)
	Gaba-a-alpha (multiple confirming inferences)
	mGluR1a (inference)
	MOR (multiple confirming inferences)
	Mus2R
	NPY
	PV (multiple confirming inferences)
	SOM (confirmed by inference)
	vGluT3 (multiple confirming inferences)

Mixed expression
	None known

Electrophysiological properties

None known

Notes

CA1 (i) 2201 IS LMR-O neurons [4096]

                                        Related types:
                                

                                        CA1 (i)2211 BC CB1R- (v2.0 on-hold)
                                

Notes:

N = 2

DWW 02/10/2015

                                        CLR 02/11/2015
                                

                                        CW 02/13/2015
                                

                                        OK. - GAA
                                

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources

Excitatory or Inhibitory

none known

Potential sources

Excitatory or Inhibitory

	DG Local-Projecting Cajal-Retzius*
	CA3 Pyramidal
	CA3c Pyramidal
	CA3c Umbrella Pyramidal*
	CA3 Trilaminar
	CA2 Pyramidal
	CA2 Bistratified
	CA1 Cajal-Retzius
	CA1 Local-Projecting Cajal-Retzius*
	CA1 Back-Projection
	CA1 Bistratified
	CA1 Hippocampo-subicular Projecting ENK+
	CA1 Ivy
	CA1 Interneuron Specific LM-R
	CA1 LMR
	CA1 LMR-LM*
	CA1 LMR-R*
	CA1 Interneuron Specific LMR-R
	CA1 LMR Projecting
	CA1 Neurogliaform
	CA1 Neurogliaform Projecting
	CA1 O-LM
	CA1 Recurrent O-LM
	CA1 O-LMR
	CA1 Recurrent O-LMR*
	CA1 Interneuron Specific O-R
	CA1 O-RP*
	CA1 Oriens-Bistratified
	CA1 Oriens-QuadA Projecting
	CA1 OR-LM
	CA1 O-RPO*
	CA1 Perforant Path-Associated
	CA1 Perforant Path-Associated QuadD
	CA1 QuadD-RP*
	CA1 Quadrilaminar
	CA1 R-Receiving Apical-Targeting
	CA1 R-RO*
	CA1 R-RP*
	CA1 Radiatum
	CA1 Interneuron Specific RO-R*
	CA1 RO-RP*
	CA1 RP-RPO*
	CA1 Schaffer Collateral-Associated
	CA1 Schaffer Collateral-Correlated*
	CA1 Schaffer Collateral-Receiving R-Targeting
	CA1 Trilaminar
	CA1 Radial Trilaminar
	Sub CA1-Projecting Pyramidal
	EC LIII Small Pyramidal
	EC LIII Pyramidal

Potential sources known to be avoided

Excitatory or Inhibitory

none known

Targets of Output

Known targets

Excitatory or Inhibitory

none known

Potential targets

Excitatory or Inhibitory

	CA1 Axo-axonic
	CA1 Horizontal Axo-axonic
	CA1 Back-Projection
	CA1 Basket
	CA1 Horizontal Basket
	CA1 Trilayer Basket*
	CA1 Basket CCK+
	CA1 Horizontal Basket CCK+*
	CA1 Trilayer Basket CCK+*
	CA1 Bistratified
	CA1 RO-receiving CA3-targeting*
	CA1 Hippocampo-subicular Projecting ENK+
	CA1 Ivy
	CA1 Interneuron Specific LMO-O
	CA1 O-LM
	CA1 Recurrent O-LM
	CA1 O-LMR
	CA1 Recurrent O-LMR*
	CA1 Interneuron Specific O-R
	CA1 O-RP*
	CA1 Interneuron Specific O-Targeting QuadD
	CA1 Oriens/Alveus
	CA1 Oriens-Bistratified
	CA1 Oriens-QuadA Projecting
	CA1 OR-LM
	CA1 O-RPO*
	CA1 Perforant Path-Associated QuadD
	CA1 QuadD-RP*
	CA1 Quadrilaminar
	CA1 Interneuron Specific RO-O
	CA1 Interneuron Specific RO-R*
	CA1 RO-RP*
	CA1 Schaffer Collateral-Correlated*
	CA1 Schaffer Collateral-Receiving R-Targeting
	CA1 SO-SO
	CA1 SO-SO Projecting*
	CA1 Trilaminar
	CA1 Radial Trilaminar

Potential targets known to be avoided

Excitatory or Inhibitory

	CA1 Pyramidal
	CA1 Deep Pyramidal
	CA1 Superficial Pyramidal

Oscillation Phase Locking