positive * Contradictory evidence exists (open all evidence to view)
All of the evidence provided on Hippocampome.org are quotes from scientific texts.
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"In somata and boutons there was no overlap between PV and VGLUT3 imunoreactivity, regardless of their colabelling with GAD, in the CA1 area (Fig 7D and E). Similarly, none of the 112 VGLUT3-positive cells tallied in other hippocampal areas and the isocortex was immunoreactive for PV."
Interpretation notes: Glutamatergic and GABAergic vGluT3+ types in CA1 SLM_SR_SP_SO are probably PV-
"The lack of PV [parvalbumin] immunoreactivity in VGLUT3[vesicular glutamate transporter type 3]-positive somata and boutons, the obligatory coexpression of VGLUT3 and CCK [cholecystokinin] in interneuronal somata and the perisomatic location of boutons double-labelled for GAD and VGLUT3 in the principal cell layers demonstrate that VGLUT3 is present in a distinct type of basket cell. Some basket cells expressing CCK but negative for PV also express VIP [vasoactive intestinal polypeptide] (reviewed in Freund & Buzsaki, 1996). However, in our material, neither VIP-positive cell bodies nor boutons were positive for VGLUT3. Therefore, the CCK- and VGLUT3-positive cells constitute a novel subtype of basket cell {CA1 Basket CCK+}."
Interpretation notes: Glutamatergic and GABAergic vGlut3+ types in CA1 SLM_SR_SP_SO are probably PV-
"The lack of PV [parvalbumin] immunoreactivity in VGLUT3[vesicular glutamate transporter type 3]-positive somata and boutons, the obligatory coexpression of VGLUT3 and CCK [cholecystokinin] in interneuronal somata and the perisomatic location of boutons double-labelled for GAD and VGLUT3 in the principal cell layers demonstrate that VGLUT3 is present in a distinct type of basket cell. Some basket cells expressing CCK but negative for PV also express VIP [vasoactive intestinal polypeptide] (reviewed in Freund & Buzsaki, 1996). However, in our material, neither VIP-positive cell bodies nor boutons were positive for VGLUT3. Therefore, the CCK- and VGLUT3-positive cells constitute a novel subtype of basket cell {CA1 Basket CCK+}."
Interpretation notes: Glutamatergic and GABAergic vGlut3+ types in CA1 SLM_SR_SP_SO are probably PV- by contrapositive logic
"Parvalbumin-immunoreactive neurons were seen in strata oriens and pyramidale, but not in strata radiatum and lacunosum-moleculare of the CA1 and CA3, while parvalbumin-immunoreactive fibers were found in all strata, but more concentrated in the stratum pyramidale."
Interpretation notes: Glutamatergic and GABAergic types in CA1 SLM_SR are negative for PV
"In the case of parvalbumin-VIP [vasoactive intestinal polypeptide] co-localization, only those VIP cells within or close to stratum pyramidale were examined, since parvalbumin cells are absent in other layers. Thus, all VIP-positive cells in the distal part of stratum radiatum or in stratum lacunosum-moleculare are considered parvalbumin-negative by their position. None of the 136 VIP-immunopositive cells near stratum pyramidale in CA1 and the 36 in CA3 showed parvalbumin immunofluorescence (Fig. 8E, F). In addition, 15 large multipolar VIPpositive basket cells were selected from different sections, but those were also negative for parvalbumin. This finding demonstrates that there is a basket cell type different from those containing parvalbumin but which is characterized by the coexistence of VIP and CCK [cholecystokinin]."
Interpretation notes: Glutamatergic and GABAergic types in CA1 SLM_SR are negative for PV
"Stratum radiatum contains no PV[parvalbumin]-positive cells; thus, CCK[cholecystokinin]-immunoreactive basket cells are PV negative
(Gulyas et al., 1991b). Direct evidence for two neurochemically
distinct types of basket cells has recently been provided (Acsady
et al., 1996a,b; see Section IV.3.d)."
Interpretation notes: Glutamatergic and GABAergic types in CA1 SR are negative for PV
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