CA1 Perforant Path-Associated QuadD
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)3222 Perforant Path-Associated QuadD S091204:Interneuron Specific:IS:CA1

Name derivation
This name is the most well known in the cited literature. The modifier describes the dendrites that invade four layers and distinguishes these cells from the canonical perforant path-associated cells.

Synonym(s)
CA1 perforant-path-associated interneuron
CA1 PPA interneuron
CA1 R-LM cell
CA1 s.r.-s.l.m. border cell

List of articles
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Hajos N  (1997) J Neurosci
Synaptic communication among hippocampal interneurons: properties of spontaneous IPSCs in morphologically identified cells.
Hajos N, Mody I.
J Neurosci, 1997 Nov 1, 17 (21), Pages: 8427 - 8442
PMID: 9334415
Tags: morphology, connectivity, synapse probabilities
Tricoire L  (2011) J Neurosci
A blueprint for the spatiotemporal origins of mouse hippocampal interneuron diversity.
Tricoire L, Pelkey KA, Erkkila BE, Jeffries BW, Yuan X, McBain CJ.
J Neurosci, 2011 Jul 27, 31 (30), Pages: 10948 - 10970
PMID: 21795545; DOI: 10.1523/JNEUROSCI.0323-11.2011
Tags: morphology, marker, membrane biophysics, firing patterns, synapse probabilities

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings

Morphology
Soma
CA1:SR
Axons
CA1:SLM
Dendrites
CA1:SLM
CA1:SR
CA1:SP
CA1:SO

Molecular markers
Positive
CoupTF II
CR (confirmed by inference)
Gaba-a-alpha (multiple confirming inferences)
mGluR1a (inference)
NPY
PV
SOM (confirmed by inference)
Sub P Rec (inference)
vGluT3
Negative
5HT-3 (confirmed by inference)
AR-beta2 (multiple confirming inferences)
CB (multiple confirming inferences)
CB1 (multiple confirming inferences)
CCK (confirmed by inference)
ChAT (multiple confirming inferences)
ENK (confirmed by inference)
ErbB4 (multiple confirming inferences)
GABAa\alpha 6 (inference)
MOR (multiple confirming inferences)
nNOS
TH (multiple confirming inferences)
VIP (confirmed by inference)
Mixed expression
AR-beta1 (unresolved inferential conflict)

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): -64±7 mV (23); 1 source
Input resistance (Rin): 216±124 MΩ (23); 1 source
Time constant (τm): 46±18 ms (23); 1 source
Threshold potential (Vthresh): 27 mV (1); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 22±3 mV (23); 1 source
Action potential amplitude (APampl): 61±7 mV (23); 1 source
Action potential width (APwidth): 0.77±0.12 ms (23); 1 source
Max firing rate (Max F.R.): >40 Hz (1); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 1.3 mV (1); 1 source
Sag ratio: 0.79±0.09 (23); 1 source

Notes
This cell type is a result of a merger between CA1 (-)3220 perforant path-associated (PPA) neurons and CA1 (-)3202 perforant path-associated (PPA) neurons. Rejected merger between CA1 (-)3202 perforant path-associated (PPA) neurons and CA1 (-)1202 pyramidal/radiatum-lacunosum moleculare (PR-LM) neurons. Related classes: CA1 (-)3200p-DG 1000-SUB 100 perforant path II (PP II) neurons (active) Tricoire (2011): Borderline D:SLM.

Firing Pattern
Images
Image MissingImage Missing
Parameters View page
NASP [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=4.66;a= 0.096;b= -44.34;d= 290;C= 12;Vr= -64.88;Vt= -51.84;Vpeak= -2.99;Vmin= -62.54; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG Local-Projecting Cajal-Retzius*
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Trilaminar
CA2 Pyramidal
CA2 Wide-Arbor Basket
CA2 Bistratified
CA1 Pyramidal
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Cajal-Retzius
CA1 Local-Projecting Cajal-Retzius*
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Horizontal Axo-axonic
CA1 Back-Projection
CA1 Basket
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Neurogliaform
CA1 Neurogliaform Projecting
CA1 O-LM
CA1 Recurrent O-LM
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 OR-LM
CA1 O-RPO*
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar
Sub CA1-Projecting Pyramidal
EC LIII Small Pyramidal
EC LIII Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
CA1 Axo-axonic
CA1 Basket
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Interneuron Specific LM-R
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Neurogliaform
CA1 Neurogliaform Projecting
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Schaffer Collateral-Associated
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
CA1 Pyramidal
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Cajal-Retzius
CA1 Local-Projecting Cajal-Retzius*
CA1 Radiatum Giant

Oscillation Phase Locking
Category
Value