negative; confirmed by inference(s) * Contradictory evidence exists (open all evidence to view)
All of the evidence provided on Hippocampome.org are quotes from scientific texts.
However, because quoted passages may be difficult to understand in isolation, contextual information and expanded abbreviations set in square brackets have been added for clarity.
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EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p 559 left bottom
"We tested CR [calretinin] and CCK[cholecystokinin]-immunolabelling in VGLUT3[vesicular glutamate transporter type 3]-positive somata in the CA1 area. Somatic CCK- or CR- labelling occurred alone in 32.7% and 54.8% of the cells, respectively. There was no colocalization between CR and VGLUT3, or CR and CCK (Fig. 7B and Table 2). Likewise, none of the tested VGLUT3-positive cells in the CA3 area/dentate gyrus (123 cells) and isocortex (40 cells) was immunoreactive for CR."
Interpretation notes: Glutamatergic and GABAergic CR+ types in CA1 SLM_SR_SP_SO are probably CCK-
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p 559 left bottom
"We tested CR [calretinin] and CCK[cholecystokinin]-immunolabelling in VGLUT3[vesicular glutamate transporter type 3]-positive somata in the CA1 area. Somatic CCK- or CR- labelling occurred alone in 32.7% and 54.8% of the cells, respectively. There was no colocalization between CR and VGLUT3, or CR and CCK (Fig. 7B and Table 2). Likewise, none of the tested VGLUT3-positive cells in the CA3 area/dentate gyrus (123 cells) and isocortex (40 cells) was immunoreactive for CR."
Interpretation notes: Glutamatergic and GABAergic CR+ types in CA1 SLM_SR_SP_SO are probably CCK- by contrapositive logic; Clopper-Pearson confidence interval lower bound = 97.1% (n = 126/126)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p1217, Table 1
"Table 1. Colocalization of type 1 cannabinoid receptor (CB1) and cholecystokinin (CCK) in the hippocampus and dentate gyrus at different post-natal ages."
Interpretation notes: Glutamatergic and GABAergic CB1- types in CA1 & CA3 SLM_SR_SP_SO are probably CCK- by contrapositive logic; Clopper-Pearson confidence interval lower bound = 87.5% (n = 509/564)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p841, Table 1
"TABLE 1. Proportion of a1 subunit-immunoreactive neurons containing GABA,
calcium-binding proteins and neuropeptide "
Interpretation notes: Glutamatergic and GABAergic GABAa alpha1+ types in CA1 SLM_SR_SP_SO are probably CCK-
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p128, right top
"In the hippocampus, CCK [cholecystokinin] immunoreactive (CCK-I) terminals were shown to form pericellular baskets around the pyramidal
cell somata and make synaptic contacts on them, and thus some of CCK immunoreactive neurons are considered to be basket cells in this region
[Harris 1985, Hendry 1985, Nunzi 1985]. However, so far our preliminary observations indicated that CCK and PV [parvalbumin] immunoreactivities are not present in the same neuron."
Interpretation notes: Glutamatergic and GABAergic PV+ types in CA1 SLM_SR_SP_SO are probably CCK-
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p128, right top
"In the hippocampus, CCK [cholecystokinin] immunoreactive (CCK-I) terminals were shown to form pericellular baskets around the pyramidal
cell somata and make synaptic contacts on them, and thus some of CCK immunoreactive neurons are considered to be basket cells in this region
[Harris 1985, Hendry 1985, Nunzi 1985]. However, so far our preliminary observations indicated that CCK and PV [parvalbumin] immunoreactivities are not present in the same neuron."
Interpretation notes: Glutamatergic and GABAergic PV+ types in CA1 SLM_SR_SP_SO are probably CCK- by contrapositive logic
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negative; confirmed by inference(s)
