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"Figure 2. [CA1] PLP [pyramidal-like principal] neurons do not stain for interneuronal markers A, PLPs were immunonegative for glutamic acid decarboxylase 65/67 (GAD 65/67; pink) and parvalbumin (PV; blue). GAD-positive interneurons were visible in all layers of CA1, in addition to the PV-positive dendrites of putative basket cells (blue). A biocytin-filled PLP neuron was stained with streptavidin/Alexa-488 (green). B, calretinin-positive interneurons were brightly stained, while neurons with PLP morphology were not visible. C, staining for excitatory amino acid transporter 3 (EAAT3) revealed an immunopositive PLP neuron (arrowhead) and a radiatum giant cell (RGC; arrow), along with numerous pyramidal neurons."
"We then incubated slices with an antibody for excitatory amino acid transporter 3 (EAAT3, EAAC1). Although known to be present on inhibitory neurons in the cerebellum, EAAT3 consistently stains pyramidal neurons in the hippocampus (Rothstein et al. 1994; Kanai et al. 1995). We found dense staining for both [CA1] pyramidal neurons and [CA1] neurons with PLP [pyramidal-like principal neuron] morphology in the [CA1] SR [stratum radiatum] (Fig. 2C, arrowhead). Also present were neurons with the typical 'radiatum giant cell' (RGC) morphology (Gulyas et al. 1998) as described below (Fig. 2C, arrow)."
"Figure 2. [CA1] PLP [pyramidal-like principal] neurons do not stain for interneuronal markers A, PLPs were immunonegative for glutamic acid decarboxylase 65/67 (GAD 65/67; pink) and parvalbumin (PV; blue). GAD-positive interneurons were visible in all layers of CA1, in addition to the PV-positive dendrites of putative basket cells (blue). A biocytin-filled PLP neuron was stained with streptavidin/Alexa-488 (green). B, calretinin-positive interneurons were brightly stained, while neurons with PLP morphology were not visible. C, staining for excitatory amino acid transporter 3 (EAAT3) revealed an immunopositive PLP neuron (arrowhead) and a radiatum giant cell (RGC; arrow), along with numerous pyramidal neurons."
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