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| Morphology |
| Soma | |
| CA1:SR | |
| CA1:SP |
| Axons | |
| CA1:SO |
| Dendrites | |
| CA1:SLM | |
| CA1:SR |
| Representative figure |
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Stratum radiatum giant cells: a type of principal cell in the rat hippocampus. Gulyas AI, Toth K, McBain CJ, Freund TF Eur J Neurosci, 1998 Dec, 10 (12), pages: 3813 - 3822 PMID: 9875359; DOI: 10.1046/j.1460-9568.1998.00402.x |
 "FIG. 2. Morphological features of RGCs [radiatum giant cells] {CA1 Radiatum Giant} [of CA1]. The dendritic morphology of RGCs {CA1 Radiatum Giant} changes gradually from its most characteristic form (no. 1) to morphology resembling pyramidal cells (no. 5), although far away from stratum pyramidale. Most often (nos 1-2) two thick primary apical dendrites and no basal dendrites arise from the soma. The dendrites ascend and reach the hippocampal fissure emitting numerous fine secondary branches in stratum radiatum and considerably less in stratum lacunosum-moleculare. A smaller number of cells with numerous thin basal dendrites (nos. 3-5) can also be observed. The axons, like those of pyramidal cells arise from the basal pole of the soma, descend to stratum oriens where they emit local collaterals restricted to stratum oriens, while their main myelinated branches penetrate the alveus and invariably turn towards the fimbria (arrows label the cut main axons in stratum oriens). Scale: 100 [micro]m. Abbreviations: s.l-m.: stratum lacunosum-moleculare; s.r.: stratum radiatum; s.p.: stratum pyramidale; s.o.: stratum oriens." |
| Molecular markers |
| Positive | |
| EAAT3 | |
| GluA2/3 |
| Negative | |
| CB1 (multiple confirming inferences) | |
| CCK (confirmed by inference) | |
| CR | |
| ENK (inference) | |
| GABAa\alpha 6 (inference) | |
| PV | |
| vGluT3 (inference) |
| Mixed expression | |
| None known |
| Electrophysiological properties |
| Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max] | |
| Resting membrane potential (Vrest): -66±3.6 mV (16); 2 sources (23): [-66 , -63] | |
| Input resistance (Rin): 56±14.0 MΩ (25); 2 sources (32): [56 , 86] | |
| Threshold potential (Vthresh): 30 mV (1); 2 sources (2): [30 , 32] | |
| Fast afterhyperpolaziring potential amplitude (Fast AHP): 6 mV (1); 2 sources (2): [6 , 15.4] | |
| Action potential amplitude (APampl): 69 mV (1); 2 sources (2): [69 , 107] | |
| Sag ratio: 0.61 (1); 1 source | |
| Time constant (τm): 50±3 ms (7); 1 source | |
| Action potential width (APwidth): 1.9±0.09 ms (7); 1 source | |
| Max firing rate (Max F.R.): >26 Hz (1); 1 source | |
| Slow afterhyperpolarizing potential amplitude (Slow AHP): 8.3 mV (1); 1 source |
| Notes |
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CA1 (e)2201 Radiatum Giant Cells (CA1 RGC) [4054] Merger status: Merger of CA1 (+)2221 pyramidal-like principal (PLP) cells and CA1 (+)2201 radiatum giant cells (RGC). Notes: CA1 PLP 2221 cell type contains unverified connections to SUB and EC. There is no CLEAR evidence for dendrites in SP in either cell type. The PLP cell type text mentions "soma located approximately 50 microm from the SP." Based on the scale bar, basal dendrites are located near the SR/SP border and just within fuzzy boundaries for the principal layer. The RGC cell type has Gulyas (1998) Fig 2, which shows the soma of cells 1-3 also located about 50-100 microm from the SR/SP border, and it looks like the dendrites have similar extent to PLP cells. Cell #5 does not have dendrites near SP, so it likely will NOT fit into a 2221 interpretation. In the PLP cell type, Poolos et al declare PLPs to be a subset of RGCs based on bifurcation patterns of the apical dendrites and soma shape. However, there appears to be no current basis for hippocampome subclasses. CLR DWW CW GAA Supplement Notes: Rin, tau, Vm, APthresh, APampl, Apwidth, FP. DWW 05/23/2022 I concur with the 2201 AD pattern. - JDK 05/23/2022
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| Firing Pattern |
| Images | |
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| Parameters | View page | |
| NASP | [Evidence] [Firing Pattern] | |
| RASP.SLN | [Evidence] [Firing Pattern] | |
| TSTUT. | [Evidence] [Firing Pattern] |
| Izhikevich Model |
| Parameters | Single Compartment | Downloads | Simulate |
| subtype: 1 k=0.73;a= 0;b= 91.37;d= 100;C= 725;Vr= -66.09;Vt= -27.01;Vpeak= 13.37;Vmin= -46.97; | Simulate |
| Images | |
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| ModelDB Model |
| Model Accession Number | PubMed ID |
| Sources of Input |
| Targets of Output |
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| Oscillation Phase Locking |
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