positive * Contradictory evidence exists (open all evidence to view)
All of the evidence provided on Hippocampome.org are quotes from scientific texts.
However, because quoted passages may be difficult to understand in isolation, contextual information and expanded abbreviations set in square brackets have been added for clarity.
"All VGLUT3-positive somata [in CA1] were negative for VIP, but 10.7 +/- 2.5% of CCK-positive cells were also positive for VIP (Fig. 7A and Table 2). This figure is similar to that reported by Kosaka et al. (1985). In these reactions more than 20% of CCK-positive interneurons was also VGLUT3-positive in their perikarya (Table 2). None of the tested VGLUT3-positive neurons in the CA3 area/dentate gyrus (54 cells) and isocortex (24 cells) was immunoreactive for VIP."
Interpretation notes: Glutamatergic and GABAergic vGluT3+ types in CA1 SLM_SR_SP_SO are probably VIP-
"The lack of PV [parvalbumin] immunoreactivity in VGLUT3[vesicular glutamate transporter type 3]-positive somata and boutons, the obligatory coexpression of VGLUT3 and CCK [cholecystokinin] in interneuronal somata and the perisomatic location of boutons double-labelled for GAD and VGLUT3 in the principal cell layers demonstrate that VGLUT3 is present in a distinct type of basket cell. Some basket cells expressing CCK but negative for PV also express VIP [vasoactive intestinal polypeptide] (reviewed in Freund & Buzsaki, 1996). However, in our material, neither VIP-positive cell bodies nor boutons were positive for VGLUT3. Therefore, the CCK- and VGLUT3-positive cells constitute a novel subtype of basket cell {CA1 Basket CCK+}."
Interpretation notes: Glutamatergic and GABAergic vGlut3+ types in CA1 SLM_SR_SP_SO are probably VIP-
"The lack of PV [parvalbumin] immunoreactivity in VGLUT3[vesicular glutamate transporter type 3]-positive somata and boutons, the obligatory coexpression of VGLUT3 and CCK [cholecystokinin] in interneuronal somata and the perisomatic location of boutons double-labelled for GAD and VGLUT3 in the principal cell layers demonstrate that VGLUT3 is present in a distinct type of basket cell. Some basket cells expressing CCK but negative for PV also express VIP [vasoactive intestinal polypeptide] (reviewed in Freund & Buzsaki, 1996). However, in our material, neither VIP-positive cell bodies nor boutons were positive for VGLUT3. Therefore, the CCK- and VGLUT3-positive cells constitute a novel subtype of basket cell {CA1 Basket CCK+}."
Interpretation notes: Glutamatergic and GABAergic vGlut3+ types in CA1 SLM_SR_SP_SO are probably VIP- by contrapositive logic
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