CA1 Horizontal Basket
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)0012 Horizontal Basket S110704:Perisomatic-targeting:Basket:CA1

Name derivation
This straightforward name derives from the more common name in the cited literature and is the basket cell variant of the literature-based CA1 Horizontal Axo-Axonic. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 basket cell
CA1 CCK-immunopositive basket cell
CA1 fast spiking perisomatic region-targeting interneuron
CA1 perisomatic region-targeting inhibitory cell

List of articles
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Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities
Maccaferri G  (2000) J Physiol
Cell surface domain specific postsynaptic currents evoked by identified GABAergic neurones in rat hippocampus in vitro.
Maccaferri G, Roberts JD, Szucs P, Cottingham CA, Somogyi P.
J Physiol, 2000 Apr 1, 524 Pt 1, Pages: 91 - 116
PMID: 10747186; DOI: 10.1111/j.1469-7793.2000.t01-3-00091.x
Tags: morphology, marker, connectivity, synapse probabilities
Pawelzik H  (2002) J Comp Neurol
Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus.
Pawelzik H, Hughes DI, Thomson AM.
J Comp Neurol, 2002 Feb 18, 443 (4), Pages: 346 - 367
PMID: 11807843; DOI: 10.1002/cne.10118
Tags: morphology, marker, connectivity, synapse probabilities
Tyan L  (2014) J Neurosci
Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry.
Tyan L, Chamberland S, Magnin E, Camire O, Francavilla R, David LS, Deisseroth K, Topolnik L.
J Neurosci, 2014 Mar, 34 (13), Pages: 4534 - 4547
PMID: 24671999; DOI: 10.1523/JNEUROSCI.3813-13.2014
Tags: synapse probabilities
Zemankovics R  (2010) J Physiol
Differences in subthreshold resonance of hippocampal pyramidal cells and interneurons: the role of h-current and passive membrane characteristics.
Zemankovics R, Kali S, Paulsen O, Freund TF, Hajos N.
J Physiol, 2010 Jun 15, 588 (Pt 12), Pages: 2109 - 2132
PMID: 20421280; DOI: 10.1113/jphysiol.2009.185975
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities

Supplemental PMIDs
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List of Hippocampome.org to NeuroMorpho.Org mappings
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  • Bacci
    • D90203 (fits the general description of "CA1 R-P Basket" or "CA1 Basket" or "CA1 Trilayer Basket" or "CA1 Horizontal Basket" based on the distribution of axons and dendrites)
    • E091118 (fits the general description of "CA1 R-P Basket" or "CA1 Horizontal Basket" based on the distribution of axons and dendrites)
    • G90206
  • Esclapez
  • McBain
  • Topolnik

    • Morphology
    Soma
    CA1:SP
    CA1:SO
    Axons
    CA1:SP
    Dendrites
    CA1:SO

    Representative figure
    Differences in subthreshold resonance of hippocampal pyramidal cells and interneurons: the role of h-current and passive membrane characteristics.
    Zemankovics R, Kali S, Paulsen O, Freund TF, Hajos N
    J Physiol, 2010 Jun 15, 588 (Pt 12), pages: 2109 - 2132
    PMID: 20421280; DOI: 10.1113/jphysiol.2009.185975


    "Figure 1. Light microscopic reconstructions and voltage responses to current steps of the investigated cell types recorded in the stratum oriens of hippocampal CA1 region A, example artistic renderings of light microscopic reconstructions of a pyramidal cell (PC), an oriens-radiatum cell (O-R) {CA1 Oriens-Bistratified}, an oriens-lacunosum-moleculare cell (OLM) {CA1 O-LMR}, and a fast spiking perisomatic region-targeting interneuron (FS PTI) {CA1 Horizontal Basket}. Dendrites are represented in black and axons in red. Dendritic spines are enhanced for visibility."


    Molecular markers
    Positive
    5HT-3
    vGluT3
    VIP
    Negative
    CB (multiple confirming inferences)
    ChAT (multiple confirming inferences)
    Chrna2 (inference)
    CoupTF II
    CR (confirmed by inference)
    ENK (confirmed by inference)
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (multiple confirming inferences)
    mGluR1a (inference)
    nNOS
    NPY
    SOM (confirmed by inference)
    TH (multiple confirming inferences)
    Mixed expression
    CCK (subtypes)
    PV (subtypes)

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -55.4±9.5 mV (17); 2 sources (35): [-55.4 , -54]
    Input resistance (Rin): [219, 199.0] MΩ (2); 2 sources (20): [116 , 219]
    Time constant (τm): [22, 25.5] ms (2); 2 sources (20): [15.4 , 22]
    Threshold potential (Vthresh): 24 mV (1); 2 sources (2): [15 , 24]
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 11 mV (1); 2 sources (2): [9 , 11]
    Action potential amplitude (APampl): 71.39 mV (1); 2 sources (19): [60 , 71.39]
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 5.3 mV (1); 2 sources (2): [4.8 , 5.3]
    Sag ratio: 0.47 (1); 2 sources (2): [0.47 , 0.69]
    Action potential width (APwidth): 0.77±0.1 ms (18); 1 source
    Max firing rate (Max F.R.): >50 Hz (1); 1 source

    Notes
    Axo-axonic cells exclusively target pyramidal cells; basket cells also target interneurons. - The Zemankovics CA1 (-)0012 FS PTI cells are merged into this cell type even though the authors could not distinguish between axo-axonic and basket cells Target soma and proximal dendrites of CA1 pyramidal cells and other interneurons. perisomatic axonal targeting interpreted as PCL extended interpretation of SP in apical and basal directions

    Firing Pattern
    Images
    Image MissingImage Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]
    NASP [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=0.83;a= 0.002;b= 0.26;d= 1;C= 46;Vr= -55.72;Vt= -27.75;Vpeak= 20.28;Vmin= -45.42; Simulate
    subtype: 2 k=0.28;a= 0.081;b= 1.08;d= -18;C= 66;Vr= -55.89;Vt= -40.65;Vpeak= 19.81;Vmin= -45; Simulate
    Images
    Image MissingImage Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    CA3 Pyramidal
    CA3c Pyramidal
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Bistratified
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Radiatum Giant
    CA1 Back-Projection
    CA1 Bistratified
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 Interneuron Specific LMR-O*
    CA1 Recurrent O-LM
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 O-RPO*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-RO*
    CA1 Interneuron Specific RO-O
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    CA1 Pyramidal

    Potential targets
    Excitatory or Inhibitory
    CA2 Wide-Arbor Basket
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 Ivy
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 RP-RPO*
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value