negative inference; confirmed by additional inferences
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EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p 559 left bottom
"We tested CR [calretinin] and CCK[cholecystokinin]-immunolabelling in VGLUT3[vesicular glutamate transporter type 3]-positive somata in the CA1 area. Somatic CCK- or CR- labelling occurred alone in 32.7% and 54.8% of the cells, respectively. There was no colocalization between CR and VGLUT3, or CR and CCK (Fig. 7B and Table 2). Likewise, none of the tested VGLUT3-positive cells in the CA3 area/dentate gyrus (123 cells) and isocortex (40 cells) was immunoreactive for CR."
Interpretation notes: Glutamatergic and GABAergic CCK+ types in CA1 SLM_SR_SP_SO are probably CR-; Clopper-Pearson confidence interval lower bound = 97.1% (n = 126/126)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p 559 left bottom
"We tested CR [calretinin] and CCK[cholecystokinin]-immunolabelling in VGLUT3[vesicular glutamate transporter type 3]-positive somata in the CA1 area. Somatic CCK- or CR- labelling occurred alone in 32.7% and 54.8% of the cells, respectively. There was no colocalization between CR and VGLUT3, or CR and CCK (Fig. 7B and Table 2). Likewise, none of the tested VGLUT3-positive cells in the CA3 area/dentate gyrus (123 cells) and isocortex (40 cells) was immunoreactive for CR."
Interpretation notes: Glutamatergic and GABAergic CCK+ types in CA1 SLM_SR_SP_SO are probably CR- by contrapositive logic
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p311, right middle
"With the exception of one [calretinin and calbindin] double-labeled cell in the molecular layer of the dentate gyrus in one of the animals (at the temporal pole of the hippocampus), all double-labeled cells were present in specific topographical locations. The first of these was the alveus and stratum oriensof field CA1, where we observed most of the double-labeled cells (Figs. 1 and 2AB). Whereas the entire extent of the alveus and stratum oriens of field CA1 contained double-labeled cells, the largest concentration of these cells was observed in the temporal part of CA1. The second location was the small area of transition at the border between field CA1 and the subiculum where the typical palisade organization of the stratum pyramidale of field CA1 is lost and over a short trajectory becomes the loosely organized cell layer typical of the subiculum (Fig.2C, detail in Fig. 2D). Most double-labeled cells in this region were present in the temporal hippocampus). The third location of double-labeled cells was in the fimbria. Here we found some scattered double-labeled cells (Fig.1). Apart from these hippocampal locations we noted double-labeled cells in the deep layer of the ventral subiculum and some double-labeled cells in the deep layers(V-VI) of the entorhinal cortex."
Interpretation notes: Glutamatergic and GABAergic CB+ types in CA1 SLM_SR_SP are probably CR-
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p311, right middle
"With the exception of one [calretinin and calbindin] double-labeled cell in the molecular layer of the dentate gyrus in one of the animals (at the temporal pole of the hippocampus), all double-labeled cells were present in specific topographical locations. The first of these was the alveus and stratum oriensof field CA1, where we observed most of the double-labeled cells (Figs. 1 and 2AB). Whereas the entire extent of the alveus and stratum oriens of field CA1 contained double-labeled cells, the largest concentration of these cells was observed in the temporal part of CA1. The second location was the small area of transition at the border between field CA1 and the subiculum where the typical palisade organization of the stratum pyramidale of field CA1 is lost and over a short trajectory becomes the loosely organized cell layer typical of the subiculum (Fig.2C, detail in Fig. 2D). Most double-labeled cells in this region were present in the temporal hippocampus). The third location of double-labeled cells was in the fimbria. Here we found some scattered double-labeled cells (Fig.1). Apart from these hippocampal locations we noted double-labeled cells in the deep layer of the ventral subiculum and some double-labeled cells in the deep layers(V-VI) of the entorhinal cortex."
Interpretation notes: Glutamatergic and GABAergic CB+ types in CA1 SLM_SR_SP are probably CR- by contrapositive logic
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negative inference; confirmed by additional inferences