positive-negative: subcellular expression differences Explanation: Protein has been detected in dendrites, but not soma.
All of the evidence provided on Hippocampome.org are quotes from scientific texts.
However, because quoted passages may be difficult to understand in isolation, contextual information and expanded abbreviations set in square brackets have been added for clarity.
Animal:
Protocol:
Expression:
Show:
EXPRESSION: positive, negative
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p354, Fig. 8
Linking PMID: 23337532 Linking Quote: Principal neurons identified by the presence of their somata in the principal cell layer, which is densely packed with and nearly homogeneous for the somata of the subregion's principal neurons (Czeh et al., 2013, Acta Biologica Hungarica).
"Fig. 8. Distribution of the GABA A receptor subunit immunoreactivities (a1-a6, b1-b3, c1, c2 and d) in the dorsal hippocampus (coronal sections of
the mouse brain approximately Bregma 1.82 mm, according to Franklin and Paxinos, 2007). Immunohistochemical labeling was predominantly
found in the respective dendritic fields, the strata oriens (so) and radiatum (sr) of CA1 to CA3 and in the molecular layer (ml) of the dentate gyrus.
Note the faint labeling of the a3-subunit restricted to the CA1 region. A strong expression of a2- and a5-subunits occurred throughout the
hippocampus proper with highest intensity in the CA3 area. Note the co-distribution of a4- and d-subunit protein in the dentate gyrus, but not in the
CA1-CA3 region."
Browse
Search
Help
positive-negative: subcellular expression differences