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EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: mRNA
Page location: p265, left mid
"In the hippocampus, cells expressing SOM [somatostatin], PARV [parvalbumin], and GAD67 [glutamic acid decarboxylase 67] were studied in the stratum oriens of the cornu ammonis 1 (CA1), the cornu ammonis 3 (CA3), and the dentate gyrus. All neurons labeled by the digoxygenin probes in both hemispheres of three different rats were studied. A total of 391 neurons were examined (Fig. 5). In CA1, labeling for mGluR1 was found in cells expressing SOM (P<0.0001) while no significant labeling was observed in the cells expressing GAD67 or PARV. In CA3 and the dentate hilus, labeling for mGluR1 was seen strongly in cells expressing SOM and lightly in GAD67-expressing cells (P<0.0001), for both comparisons, but not for PARV-expressing cells. Fig. 6 . Other than the SOM-expressing neurons, there were no other intensely mGluR1 labeled cells seen in the stratum oriens of CA1 and CA3. There were strongly labeled neurons in the dentate hilus that did not express SOM."
Interpretation notes: Glutamatergic and GABAergic PV+ types in CA3 SO are probably mGluR1- by contrapositive logic
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negative inference