CA3 Horizontal Axo-axonic
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (i)00012 Horizontal Axo-axonic S110902:Perisomatic-targeting:Axo-axonic:CA3

Name derivation
This straightforward name derives from the more common name in the cited literature and is the CA3 variant of the literature-based CA1 Horizontal Axo-Axonic.

Synonym(s)
CA3 AAC
CA3 axo-axonic cell
CA3 perisomatic inhibitory interneuron
CA3 perisomatic inhibitory neuron
CA3 perisomatic interneuron

List of articles
Click here to view the list
Gulyas AI  (1993) Eur J Neurosci
Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region.
Gulyas AI, Miles R, Hajos N, Freund TF.
Eur J Neurosci, 1993 Dec 1, 5 (12), Pages: 1729 - 1751
PMID: 8124523; DOI: 10.1111/j.1460-9568.1993.tb00240.x
Tags: connectivity, synapse probabilities
Szabo GG  (2010) Eur J Neurosci
Distinct synaptic properties of perisomatic inhibitory cell types and their different modulation by cholinergic receptor activation in the CA3 region of the mouse hippocampus.
Szabo GG, Holderith N, Gulyas AI, Freund TF, Hajos N.
Eur J Neurosci, 2010 Jun, 31 (12), Pages: 2234 - 2246
PMID: 20529124; DOI: 10.1111/j.1460-9568.2010.07292.x
Tags: morphology, marker, membrane biophysics, connectivity, firing patterns, synapse probabilities


Morphology
Soma
CA3:SO
Axons
CA3:SP
Dendrites
CA3:SO

Molecular markers
Positive
Gaba-a-alpha (multiple confirming inferences)
PV
Negative
5HT-3 (inference)
CB (multiple confirming inferences)
CB1 (multiple confirming inferences)
CCK (multiple confirming inferences)
CR (multiple confirming inferences)
GABAa\alpha 6 (inference)
mGluR1 (inference)
vGluT3 (inference)
VIP (multiple confirming inferences)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Threshold potential (Vthresh): 26 mV (1); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 4.5 mV (1); 1 source
Action potential amplitude (APampl): 61 mV (1); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 5.6 mV (1); 1 source
Sag ratio: 0.75 (1); 1 source


Firing Pattern
Images
Image Missing
Parameters View page
ASP. [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.63;a= 0.002;b= -16.44;d= 21;C= 154;Vr= -58.52;Vt= -33.5;Vpeak= 36.09;Vmin= -38.5; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG HIPROM
CA3 Pyramidal
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Bistratified
CA3 Ivy
CA3 Lucidum ORAX
CA3 O-LM
CA3 Interneuron Specific Oriens
CA3 Interneuron Specific Quad
CA3 SO-SO
CA3 Trilaminar
CA2 Pyramidal
CA1 Back-Projection

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
CA3 Pyramidal

Potential targets
Excitatory or Inhibitory
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Ivy
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA2 Wide-Arbor Basket

Potential targets known to be avoided
Excitatory or Inhibitory
CA3 Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Bilayer Ivy*
CA3 Mossy Fiber-Associated ORDEN
CA3 Interneuron Specific Quad
CA3 QuadD-LM

Oscillation Phase Locking
Category
Value