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EXPRESSION: positive
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p1034, Figure 2
"Figure 2 Adult neurogenesis in the dentate gyrus of the hippocampus. Shown is a schematic summary of the developmental stages of dentate neurogenesis as characterized by estimated timeline for each developmental stage. Physiological properties and expression of specific molecular markers at each stage are also shown. MCL, molecular cell layer; GCL, granule cell layer; SGZ, subgranular zone. GFAP, glial fibrillary acidic protein; BLBP, brain lipid-binding protein; DCX, doublecortin; NeuN, neuronal nuclei; PSA-NCAM: the polysialylated form of the neural cell adhesion molecule NCAM; GABA, [gamma]-aminobutyric acid."
"Although no change was observed in the percentage of GFP+ cells expressing neuronal markers (~50%), there was a significant increase in the coexpression of DCX and NeuN, which was accompanied by a more differentiated neuronal morphology (Fig. 3 B, C)."
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