DG Adult-Born Immature Granule*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (e)2203p-CA3_00100 Adult-Born Immature Granule* S010101:Glutamatergic GC:Granule:DG

Name derivation
This is the most descriptive name.

Synonym(s)
DG immature GC
immature DGC
DG 14-d-old neurons
DG newborn GCs

List of articles
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Esposito MS  (2005) J Neurosci
Neuronal differentiation in the adult hippocampus recapitulates embryonic development.
Esposito MS, Piatti VC, Laplagne DA, Morgenstern NA, Ferrari CC, Pitossi FJ, Schinder AF.
J Neurosci, 2005 Nov 2, 25 (44), Pages: 10074 - 10086
PMID: 16267214; DOI: 10.1523/JNEUROSCI.3114-05.2005
Tags: morphology, marker, membrane biophysics
Vivar C  (2013) Front Neural Circuits
Functional circuits of new neurons in the dentate gyrus.
Vivar C, van Praag H.
Front Neural Circuits, 2013 Feb 25, 7, Pages: 15 -
PMID: 23443839; DOI: 10.3389/fncir.2013.00015
Tags: morphology
Zhao C  (2006) J Neurosci
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus.
Zhao C, Teng EM, Summers RG Jr, Ming GL, Gage FH.
J Neurosci, 2006 Jan 4, 26 (1), Pages: 3 - 11
PMID: 16399667; DOI: 10.1523/JNEUROSCI.3648-05.2006
Tags: morphology
Zhao C  (2008) Cell
Mechanisms and functional implications of adult neurogenesis.
Zhao C, Deng W, Gage FH.
Cell, 2008 Feb 22, 132 (4), Pages: 645 - 660
PMID: 18295581; DOI: 10.1016/j.cell.2008.01.033
Tags: morphology

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Abrous
  • Bao_Hechen
  • Gage
  • Grilli
  • Gupton_Song
  • Koehl
  • Lee_KH
  • Luikart
  • Valero_Malva
  • Varela-Nallar
  • Wadiche
  • Yamada

    • Morphology
    Soma
    DG:SG
    Axons
    DG:H
    CA3:SL
    Dendrites
    DG:SMo
    DG:SMi
    DG:H

    Molecular markers
    Positive
    DCX
    NeuN
    NeuroD
    Prox1
    PSA-NCAM
    Negative
    CGRP (inference)
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (inference)
    GluA1
    GluA2
    GluA2/3
    GluA3
    GluA4
    mGluR1
    mGluR1a (confirmed by inference)
    mGluR2/3
    mGluR5
    mGluR5a
    mGluR7a
    mGluR8a
    nNOS (inference)
    PV (inference)
    SOM (multiple confirming inferences)
    Mixed expression
    CB (subtypes)
    CR (subtypes)

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -45.6±2.3 mV (24); 2 sources (31): [-45.6 , -37.8]
    Input resistance (Rin): 2.9±0.4 MΩ (24); 2 sources (31): [2.9 , 3024]
    Fast afterhyperpolaziring potential amplitude (Fast AHP): -6.1±1.1 mV (8); 1 source
    Action potential amplitude (APampl): 43.8±3.7 mV (23); 2 sources (30): [15.8 , 43.8]
    Time constant (τm): 67.4±6.8 ms (7); 1 source

    Notes

    DG (e) 2203p Adult-born Immature Granule cells (ABI-GC) [1047]

    Related types: DG 2201p Granule cells (v1.0 active)
    DG 2203p Hilar Ectopic Granule Cells (v1.0 active)

    Notes:

    All evidence in this packet refers to 2-week-old mice. Mice lag rats in maturation by 1-2 weeks.

    axonal fibers form in H and CA3 by 2 weeks.

    forming synapses with CA3 PCs - unknown synapse formation with CA2 PCs.

    spineless apical dendritic tree.

    GABA depolarizing. slow GABAA current.

    input from hilar GABAergic interneurons.

    no glutamatergic input.

    just a few spikes not repetitive spiking.

    Vrest = -45.6 ± 2.3 (24) mV, Rin = 2.9 ± 0.4 (24) GOhm, APpeak = 43.8 ± 3.7 (23) mV, AHP = 6.1 ± 1.1 mV

    Vrest = -37.8 ± 0.8 (7) mV, Rin = 3024 ± 236 (7) MOhm, tau = 67.4 ± 6.8 (7) ms, Cm = 20.6 ± 2.1 (7) pF, Ithresh = 20.8 ± 2 (7) pA, APampl = 15.8 ± 3.1 (7) mV, maxFR < 0.5 Hz

    NeuN+, Prox1+, NeuroD+ (same as for mature GCs)

    Differences from mature GCs:

    ABI-GC GC
    [Y:D:DG:H] [N:D:DG:H]
    DCX+, PSA-NCAM+, CR+, CB- (implied) DCX- (implied), PSA-NCAM- (implied), CR- (implied), CB+
    Vrest > -50 mV Vrest < -70 mV
    Rin > 2 GOhm Rin < 300 MOhm
    tau > 55 ms tau < 30 ms
    fAHP < 8 mV fAHP > 10 mV
    APampl < 20 mV APampl > 60 mV
    maxFR < 0.5 Hz maxFR > 60 Hz
    GABA depolarizing GABA hyperpolarizing
    no glutamatergic input input from MCs, CA3c PCs, LEC, MEC
    spineless apical dendritic tree spiny apical dendritic tree
    a few isolated spikes repetitive spiking

    CLR 01/15/2016

    DWW 01/20/2016

    GAA 01/21/2016

    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy
    DG Mossy MOLDEN
    DG AIPRIM
    DG Axo-axonic
    DG COM-MOPP*
    DG HICAP
    DG Hilus-Associated Interneuron*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 Perforant Path-Associated Projecting*
    CA2 Pyramidal
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Back-Projection
    CA1 LMR Projecting
    CA1 Neurogliaform Projecting
    CA1 Perforant Path-Associated
    EC LI-II Pyramidal-Fan
    MEC LII Stellate
    EC LII-III Pyramidal-Tripolar
    EC LIV-V Pyramidal-Horizontal
    MEC LV Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    DG Interneuron Specific COLTAR*
    DG Interneuron Specific IMOT*
    DG Interneuron Specific HIMOLD*
    DG Interneuron Specific HIPRO*
    CA3 Interneuron Specific Quad

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Mossy
    DG Mossy MOLDEN
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Basket
    DG Basket CCK+
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG HIPROM
    DG Ivy*
    DG MOLAX
    DG Outer Molecular Layer
    DG Total Molecular Layer
    CA3 Pyramidal
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Axo-axonic
    CA3 Basket
    CA3 Basket CCK+
    CA3 Mossy Fiber-Associated Basket CCK+*
    CA3 Bistratified
    CA3 Ivy
    CA3 Bilayer Ivy*
    CA3 LMR-Targeting
    CA3 Lucidum*
    CA3 Lucidum LAX
    CA3 Lucidum ORAX
    CA3 Lucidum-Radiatum
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 Interneuron Specific Quad
    CA3 QuadD-LM

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value