negative inference; confirmed by additional inferences
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EXPRESSION: negative (inference)
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p49, Table 2
"Table 2. Co-localization between neuropeptides and calcium-binding proteins"
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG H are probably PV-; Clopper-Pearson confidence interval lower bound = 85.2% (n = 23/23)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: mRNA
Page location: p3161, left top
"No SS [somatostatin] immunoreactivity was found in any 5-HT[serotonin] 3 R[receptor]-expressing neurons, although single SS-immunopositive or 5-HT 3 R-expressing neurons were identified readily in cortex and hippocampus."
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG SMo_SMi_SG_H are probably 5HT-3- by contrapositive logic
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p400, right bottom
"In the dentate gyrus, the majority (95%) of hilar SOM[somatostatin]-containing neurons were also shown
to be immunoreactive for NOS [nitric oxide synthase]. In the same region, only a negligible
number (5%) of PV[parvalbumin]-positive cells contained NOS immunoreactivity
(Dun et al., 1994; Divila et al., 1995)."
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG H are probably PV-; Clopper-Pearson confidence interval lower bound = 91.6% (n = 511/544)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p400, right bottom
"In the dentate gyrus, the majority (95%) of hilar SOM[somatostatin]-containing neurons were also shown
to be immunoreactive for NOS [nitric oxide synthase]. In the same region, only a negligible
number (5%) of PV[parvalbumin]-positive cells contained NOS immunoreactivity
(Dun et al., 1994; Divila et al., 1995)."
Interpretation notes: Glutamatergic and GABAergic nNos+ types in DG H are probably PV-; Clopper-Pearson confidence interval lower bound = 93.7% (n = 445/464)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p400, right bottom
"In the dentate gyrus, the majority (95%) of hilar SOM[somatostatin]-containing neurons were also shown
to be immunoreactive for NOS [nitric oxide synthase]. In the same region, only a negligible
number (5%) of PV[parvalbumin]-positive cells contained NOS immunoreactivity
(Dun et al., 1994; Divila et al., 1995)."
Interpretation notes: Glutamatergic and GABAergic nNos+ types in DG H are probably PV- by contrapositive logic; Clopper-Pearson confidence interval lower bound = 92.2% (n = 357/376)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p841, Table 2
"TABLE 2. Proportion of neurons stained for GABA, calcium-binding proteins
and neuropeptides expressing the a1 subunit-immunoreactivity "
Interpretation notes: Glutamatergic and GABAergic GABAa alpha1- types in DG Smi_Smo_SG_H are probably PV- by contrapositive logic
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p2957, Table 1
"Table 1. Number of neurons containing immunoreactivity to NOS [nitric oxide synthase], SSN [somatostatin], and PV [parvalbumin] in the dentate hilus of the rat dorsal hippocampus"
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG H are probably PV-; Clopper-Pearson confidence interval lower bound = 91.6% (n = 511/544)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p2957, Table 1
"Table 1. Number of neurons containing immunoreactivity to NOS [nitric oxide synthase], SSN [somatostatin], and PV [parvalbumin] in the dentate hilus of the rat dorsal hippocampus"
Interpretation notes: Glutamatergic and GABAergic nNos+ types in DG H are probably PV-; Clopper-Pearson confidence interval lower bound = 93.7% (n = 445/464)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p2957, Table 1
"Table 1. Number of neurons containing immunoreactivity to NOS [nitric oxide synthase], SSN [somatostatin], and PV [parvalbumin] in the dentate hilus of the rat dorsal hippocampus"
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG H are probably PV- by contrapositive logic; Clopper-Pearson confidence interval lower bound = 84.5% (n = 259/292)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p2957, Table 1
"Table 1. Number of neurons containing immunoreactivity to NOS [nitric oxide synthase], SSN [somatostatin], and PV [parvalbumin] in the dentate hilus of the rat dorsal hippocampus"
Interpretation notes: Glutamatergic and GABAergic nNos+ types in DG H are probably PV- by contrapositive logic; Clopper-Pearson confidence interval lower bound = 92.2% (n = 357/376)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p36, Table 3
"Table 3. Number of calretinin- and/or parvalbumin-immunoreactive nonpyramidal cells "
Interpretation notes: Glutamatergic and GABAergic CR+ types in DG H are probably PV-; Clopper-Pearson confidence interval lower bound = 95.4% (n = 79/79)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p36, Table 3
"Table 3. Number of calretinin- and/or parvalbumin-immunoreactive nonpyramidal cells "
Interpretation notes: Glutamatergic and GABAergic CR+ types in DG H are probably PV- by contrapositive logic; Clopper-Pearson confidence interval lower bound = 90.7% (n = 38/38)
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p 193 left
Linking PMID: 2419523 Linking Quote: Citation included in evidentiary quote.
"Conversely, the numerous and distinct populations of hilar somatostatin-immunoreactive cells and hilar mossy cells identified in previous studies (Ribak et al., '85; Sloviter and Nilaver, '87) do not exhibit PV-LI [parvalbumin-like immunoreactivity] or CaBP-LI [calbindin D(28k)-like immunoreactivity]."
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG H are probably PV-
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p128, right bottomtom
"Our preliminary study also indicated that in the dentate gyrus PV-I [parvalbumin-immunoreactive] perikarya did not contain somatostatin immunoreactivity. However, in the hippocampus, a few PV-I neurons, especially those somewhat faintly immunoreactive, contained somatostatin immunoreactivity, indicating some overlapping of PV-I GABA[gamma amino butyric acid]ergic neurons with those containing somatostatin (our unpublished observations). "
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG Smo_Smi_SG_H are probably PV- by contrapositive logic
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negative inference; confirmed by additional inferences
