negative inference; confirmed by additional inferences
All of the evidence provided on Hippocampome.org are quotes from scientific texts.
However, because quoted passages may be difficult to understand in isolation, contextual information and expanded abbreviations set in square brackets have been added for clarity.
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EXPRESSION: negative (inference)
ANIMAL: mouse
PROTOCOL: immunohistochemistry, mRNA
Page location: p350, right bottom
Linking PMID: 23337532 Linking Quote: Principal neurons identified by the presence of their somata in the principal cell layer, which is densely packed with and nearly homogeneous for the somata of the subregion's principal neurons (Czeh et al., 2013, Acta Biologica Hungarica).
"The localization of the a6 subunit
mRNA and immunoreactivity was largely restricted to
the cerebellum, where mRNA and protein were
abundantly expressed."
Interpretation notes: Glutamatergic and GABAergic types in DG Smi_Smo_SG_H are negative for GABAaalpha 6
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p554, table 2
Linking PMID: 18546278 Linking Quote: Principal neurons identified by the presence of their somata in the principal cell layer, which is densely packed with and nearly homogeneous for the somata of the subregion's principal neurons (Czeh et al., 2013, Acta Biologica Hungarica).
"TABLE 2. Distribution of Interneurons in the Rat Hippocampus Sagittal sections (50 micrometers) of the rat hippocampus were probed with antibodies raised against somatostatin, parvalbumin, neuropeptide Y, calbindin, cholecystokinin, and calretinin. The total number of cells expressing each marker in each region is given along with the number of 50-micrometer slices analyzed. The total is further broken down to give the number of cells expressing each marker in each layer of each region of the hippocampus. These data are also given as a percentage of the total number of marker expressing cells in that region. Principal cells in the granule cell layer of the dentate gyrus and stratum pyramidale of CA1 express calbindin, preventing identification of interneurons in these regions, have therefore been omitted."
Interpretation notes: Glutamatergic and GABAergic types in DG Smo_Smi are negative for SOM
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p555, table 3
"TABLE 3. Distribution of 1 and 2 Adrenergic Receptor Expression in Interneurons in the Adult Rat Hippocampus"
Interpretation notes: Glutamatergic and GABAergic types in DG Smo_Smi are negative for SOM
EXPRESSION: negative (inference)
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p60, right mid
"The neuromodulatory protein somatostatin (SS) was exclusively expressed in hilar neurons and absent from cells in the molecular layer in both age groups (Fig. 4D)."
Interpretation notes: Glutamatergic and GABAergic types in DG Smo_Smi are negative for SOM
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p225, right top
"Somatostatin neurons constitute one of the largest chemically defined subgroups of GABA [gamma aminobutyric acid] neurons in the dentate gyrus, and virtually all somatostatin neurons of this region are located within the hilus (Fig. 5A)."
Interpretation notes: Glutamatergic and GABAergic types in DG Smo_Smi are negative for SOM
EXPRESSION: negative (inference)
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p801, left mid
Linking PMID: 15026120 Linking Quote: Negative Layer: The molecular biomarker expression is negative for the parcel; therefore, all neuron types with somata exclusively in the parcel are inferred to be negative
"On the other hand, SOM [somatostatin]-LIR [like immunoreactive] neurons showed a quite uneven distribution pattern. In the CA1 region, many SOM [somatostatin]-LIR neurons were seen in the stratum oriens (SO), while they were rarely found in the other layers. In the CA3 region,SOM [somatostatin]-LIR neurons were more widely spread. They were seen not only in the SO but also in the SP [stratum pyramidale], SL [statum lucidum] and SR [stratum radiatum]. In the dentate gyrus, SOM [somatostatin]-LIR neurons were exclusively found in the hilus."
Interpretation notes: Glutamatergic and GABAergic types in DG Smo_Smi_SG are negative for SOM
EXPRESSION: negative (inference)
ANIMAL: rat
PROTOCOL: immunohistochemistry
Page location: p775, right mid
"In these experiments, all the cells of the hippocampus immunoreactive for somatostatin were strongly immunoreactive for mGluR[metabotropic glutamate receptor]lalpha, and likewise the cells immunoreactive for mGluRla were also immunoreactive for somatostatin (Figures 2A and 2B)."
Interpretation notes: Glutamatergic and GABAergic mGluR1a- types in DG Smo_Smi_SG_H are probably SOM- by contrapositive logic
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negative inference; confirmed by additional inferences
