negative inference; confirmed by additional inferences
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EXPRESSION: negative (inference)
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p731, Fig. 4
Linking PMID: 19655320 Linking Quote: Principal neurons identified by the presence of their somata in the principal cell layer, which is densely packed with and nearly homogeneous for the somata of the subregion's principal neurons (Czeh et al., 2013, Acta Biologica Hungarica).
"FIGURE 4. SOM [somatostatin] cells do not express ErbB4. (A) The distribu-
tion of SOM-immunoreactive somata is similar to PV [parvalbumin] cells; they
are mostly confined to layers so [stratum oriens], sp [stratum pyramidale], and hi [hilus]. In CA3 close to DG,
however, SOM cells are also frequently found in sr [stratum radiatum]. Note the dense
fiber plexus in slm [stratum lacunosum-moleculare] of CA1 that is the terminal field of O-LM [oriens--lacunosum-moleculare] cell
projections. Single channel images (B-C) show that most somata
are immunoreactive for either SOM (open arrows) or ErbB4
(arrows); however, one cell in sr coexpresses both markers (arrow-
head). The quantitative analysis (n = 3) reveals that the maximum
coexpression is 2% in both SOM cells (D) and ErbB4 cells (E)."
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG Smo_Smi_SG_H are probably ErbB4-
EXPRESSION: negative (inference)
ANIMAL: mouse
PROTOCOL: immunohistochemistry
Page location: p731, Fig. 4
Linking PMID: 19655320 Linking Quote: Principal neurons identified by the presence of their somata in the principal cell layer, which is densely packed with and nearly homogeneous for the somata of the subregion's principal neurons (Czeh et al., 2013, Acta Biologica Hungarica).
"FIGURE 4. SOM [somatostatin] cells do not express ErbB4. (A) The distribu-
tion of SOM-immunoreactive somata is similar to PV [parvalbumin] cells; they
are mostly confined to layers so [stratum oriens], sp [stratum pyramidale], and hi [hilus]. In CA3 close to DG,
however, SOM cells are also frequently found in sr [stratum radiatum]. Note the dense
fiber plexus in slm [stratum lacunosum-moleculare] of CA1 that is the terminal field of O-LM [oriens--lacunosum-moleculare] cell
projections. Single channel images (B-C) show that most somata
are immunoreactive for either SOM (open arrows) or ErbB4
(arrows); however, one cell in sr coexpresses both markers (arrow-
head). The quantitative analysis (n = 3) reveals that the maximum
coexpression is 2% in both SOM cells (D) and ErbB4 cells (E)."
Interpretation notes: Glutamatergic and GABAergic SOM+ types in DG Smo_Smi_SG_H are probably ErbB4- by contrapositive logic
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negative inference; confirmed by additional inferences
