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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) EC (e)231000 LI-II Multipolar-Pyramidal S061706:Glutamatergic II:LI-II:EC Name derivation This name is a hybrid of the two most frequently cited names. Synonym(s) EC layer I small multipolar cell EC layer I small spherical multipolar neuron LEC LI multipolar principal neuron LEC LII fan neuron LEC LII oblique pyramidal neuron LEC LII pyramidal neuron MEC LI horizontal principal neuron MEC LI multipolar principal neuron List of articles Click here to view the list Burgalossi A  (2011) Neuron Microcircuits of functionally identified neurons in the rat medial entorhinal cortex. Burgalossi A, Herfst L, von Heimendahl M, Forste H, Haskic K, Schmidt M, Brecht M. Neuron, 2011 May 26, 70 (4), Pages: 773 - 86 PMID: 21609831; DOI: 10.1016/j.neuron.2011.04.003 Tags: phases, synapse probabilities Canto CB  (2012) Hippocampus Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex. Canto CB, Witter MP. Hippocampus, 2012 Jun, 22 (6), Pages: 1277 - 1299 PMID: 22161956; DOI: 10.1002/hipo.20993 Tags: morphology, synapse probabilities Canto CB  (2012) Hippocampus Cellular properties of principal neurons in the rat entorhinal cortex. I. The lateral entorhinal cortex. Canto CB, Witter MP. Hippocampus, 2012 Jun, 22 (6), Pages: 1256 - 1276 PMID: 22162008; DOI: 10.1002/hipo.20997 Tags: morphology, membrane biophysics, firing patterns, synapse probabilities Wouterlood FG  (2000) J Comp Neurol Calretinin in the entorhinal cortex of the rat: distribution, morphology, ultrastructure of neurons, and co-localization with gamma-aminobutyric acid and parvalbumin. Wouterlood FG, van Denderen JC, van Haeften T, Witter MP. J Comp Neurol, 2000 Sep 18, 425 (2), Pages: 177 - 192 PMID: 10954838; DOI: 10.1002/1096-9861(20000918)425:2<177::AID-CNE2>3.0.CO;2-G Tags: morphology, marker Supplemental PMIDs Click here to view the list of PMIDs 21609831

Morphology

Soma
	EC:I
	EC:II

Axons
	EC:II
	EC:III

Dendrites
	EC:I
	EC:II

Molecular markers

Positive
	CR

Negative
	CB (multiple confirming inferences)
	CB1 (inference)
	GABAa\alpha 6 (inference)
	PV (multiple confirming inferences)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): [-70.0, -56.0] mV (2); 1 source
	Input resistance (Rin): 430±121.7 MΩ (37); 1 source
	Time constant (τm): 25±15.2 ms (37); 1 source
	Threshold potential (Vthresh): [8.1, 23.1] mV (2); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): [3.7, 7.3] mV (2); 1 source
	Action potential amplitude (APampl): 77.5±15.2 mV (37); 1 source
	Action potential width (APwidth): 1.22±0.4 ms (37); 1 source
	Max firing rate (Max F.R.): >50 Hz (1); 1 source
	Slow afterhyperpolarizing potential amplitude (Slow AHP): 4.7 mV (1); 1 source
	Sag ratio: 0.78±0.1 (37); 1 source

Notes

This cell type represents a merger between LEC (+)231000 fan-oblique pyramidal II and EC (+)231000 MPN I. Failed unofficial merger proposals with MEC 331111 stellate II, EC 331000 excitatory II, and EC 221100 oblique pyramidal-stellate II. Spiny, principal -> excitatory. 70% of multipolar I are excitatory (Wouterlood 2000). A class of EC oblique pyramidal cells with A:I has been split off into a separate 331000 class based on a strong statement in the text about axons reaching the level of the pia with a diameter of up to 900 microm. However, note that Figure 5 Panels A and B do not support this statement. The second fan neuron shown in Figure 5 is included in the 331000 cell type. The text notes that axons are occasionally in deep layer I (as they are in this neuron). However, since the 331000 cell type is pre-existing, that neuron is included there in spite of the hippocampome rule about the word "occasionally."

Firing Pattern

Images

Parameters		View page
	ASP.	[Evidence] [Firing Pattern]
	NASP	[Evidence] [Firing Pattern]
	RASP.	[Evidence] [Firing Pattern]

Izhikevich Model

Parameters	Single Compartment	Downloads	Simulate
	subtype: 1 k=0.37;a= 0.001;b= -4.08;d= 13;C= 204;Vr= -70.53;Vt= -39.99;Vpeak= 3.96;Vmin= -54.95;	[FitFiles][CSV][XPP][Ensemble]	Simulate
	subtype: 2 k=1.53;a= 0.001;b= 0.01;d= 7;C= 286;Vr= -56.14;Vt= -39.78;Vpeak= 18.27;Vmin= -49.81;	[FitFiles][CSV][XPP][Ensemble]	Simulate

Images

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory CA2 Pyramidal EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar LEC LIII Multipolar Principal LEC LIII Complex Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal MEC LV Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LI Neurogliaform* EC LII-III Superficial Polymorphic Interneuron* MEC LIII Superficial Trilayered Interneuron

Potential sources known to be avoided Excitatory or Inhibitory none known

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Oblique Pyramidal MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar LEC LIII Multipolar Principal MEC LIII Multipolar Principal EC LIII Small Pyramidal LEC LIII Complex Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal EC LIV-V Pyramidal-Horizontal MEC LV Principal* MEC LV Pyramidal EC LV Deep Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform EC LIII Bipolar Interneuron* LEC LIII Multipolar Interneuron MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron MEC LIII Superficial Trilayered Interneuron

Potential targets known to be avoided Excitatory or Inhibitory none known

Oscillation Phase Locking

Category

Value