EC LIV-V Pyramidal-Horizontal
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
EC (e)220233p-DG_1000 LIV-V Pyramidal-Horizontal S081906:Glutamatergic Deep:LIV-VI:EC

Name derivation
This name is a hybrid of the two most frequently cited names.

Synonym(s)
LEC layer V horizontal cell
LEC layer V horizontal neuron
LEC layer V large pyramidal cell
MEC large pyramid located near the layer IV/V transition
MEC layer V horizontal cell
MEC layer V large pyramidal cell
MEC layer V pyramidal neuron
MEC LV superficial pyramidal neuron
MEC spindle shaped cell from the layer IV/V transition

List of articles
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Canto CB  (2008) Neural Plast
What does the anatomical organization of the entorhinal cortex tell us?
Canto CB, Wouterlood FG, Witter MP.
Neural Plast, 2008, 2008, Pages: 381243 -
PMID: 18769556; DOI: 10.1155/2008/381243
Tags: morphology, marker, connectivity, synapse probabilities
Canto CB  (2012) Hippocampus
Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex.
Canto CB, Witter MP.
Hippocampus, 2012 Jun, 22 (6), Pages: 1277 - 1299
PMID: 22161956; DOI: 10.1002/hipo.20993
Tags: morphology, synapse probabilities
Gloveli T  (2001) Eur J Neurosci
Properties of entorhinal cortex deep layer neurons projecting to the rat dentate gyrus.
Gloveli T, Dugladze T, Schmitz D, Heinemann U.
Eur J Neurosci, 2001 Jan, 13 (2), Pages: 413 - 420
PMID: 11168548; DOI: 10.1046/j.0953-816X.2000.01405.x
Tags: morphology, connectivity, synapse probabilities
Hamam BN  (2000) J Comp Neurol
Morphological and electrophysiological characteristics of layer V neurons of the rat medial entorhinal cortex.
Hamam BN, Kennedy TE, Alonso A, Amaral DG.
J Comp Neurol, 2000 Mar 20, 418 (4), Pages: 457 - 472
PMID: 10713573; DOI: 10.1002/(SICI)1096-9861(20000320)418:4<457::AID-CNE7>3.0.CO;2-L
Tags: morphology, synapse probabilities
Hamam BN  (2002) J Comp Neurol
Morphological and electrophysiological characteristics of layer V neurons of the rat lateral entorhinal cortex.
Hamam BN, Amaral DG, Alonso AA.
J Comp Neurol, 2002 Sep 9, 451 (1), Pages: 45 - 61
PMID: 12209840; DOI: 10.1002/cne.10335
Tags: morphology, synapse probabilities
Lingenhohl K  (1991) Exp Brain Res
Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains.
Lingenhohl K, Finch DM.
Exp Brain Res, 1991, 84 (1), Pages: 57 - 74
PMID: 1713171; DOI: 10.1007/BF00231762
Tags: morphology

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Rice-Baylor
    • AR-1-20-04-A (fits the general description of "MEC LV Pyramidal" or "EC LV Deep Pyramidal" or "MEC LV Superficial Pyramidal" or "MEC LV Multipolar-Pyramidal" or "MEC LV-VI Pyramidal-Polymorphic" or "EC LIV-V Pyramidal-Horizontal" based on the distribution of axons and dendrites)
    • AR-1-20-04-B (fits the general description of "EC LV Deep Pyramidal" or "MEC LV Superficial Pyramidal" or "EC LIV-V Pyramidal-Horizontal" based on the distribution of axons and dendrites)
    • AR-1-20-04-C (fits the general description of "MEC LV Superficial Pyramidal" or "EC LIV-V Pyramidal-Horizontal" based on the distribution of axons and dendrites)
    • more ...

    • Morphology
    Soma
    EC:IV
    EC:V
    Axons
    DG:SMo
    EC:V
    EC:VI
    Dendrites
    EC:I
    EC:II
    EC:IV
    EC:V
    EC:VI

    Representative figure
    Properties of entorhinal cortex deep layer neurons projecting to the rat dentate gyrus.
    Gloveli T, Dugladze T, Schmitz D, Heinemann U
    Eur J Neurosci, 2001 Jan, 13 (2), pages: 413 - 420
    PMID: 11168548; DOI: 10.1046/j.0953-816X.2000.01405.x


    "FIG. 2. Representative example of a pyramidal neuron of the [entorhinal cortex] deep layers with oscillatory properties {EC LIV-V Pyramidal-Horizontal}. (A) Camera lucida reconstruction of a neuron with a soma located in [entorhinal cortex] layer V and with an axon terminated in the outer molecular layer of the DG [dentate gyrus]. For better visualization, the soma and dendrites are drawn in black, the axon is drawn in red. For abbreviations, see Fig. 1A. Diagram in inset A, indicates the position of the somata of all 9 biocytin-labelled cells in the slice."


    Molecular markers
    Positive
    None known
    Negative
    GABAa\alpha 6 (inference)
    Mixed expression
    SOM (subtypes)

    Electrophysiological properties
    None known

    Notes
    This cell type is a result of a merger between EC (+)220233 pyramidal V neurons, EC (+)020233p-DG 1000 pyramidal projection V neurons, and EC (+)220031 horizontal V neurons. Likely excitatory cells (Lingenhohl -> spiny; Gloveli 2001 -> GABA negative, projecting, "similar EP characteristics to principal neurons"; Hamam 2002 -> projecting, sparsely spiny). There is limited axonal info for Lingenhöhl & Finch cell 13. L&F's cell 10 was removed because NO axonal information is reported. Lingenhöhl & Finch no longer have access to their reconstructions and could not provide the neurolucida data. Gloveli's Figure 2 is a representative example (n > 1). D:I are borderline, which is complicated by the fact that the layer I/II border is not shown.

    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    CA2 Pyramidal
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    Sub EC-Projecting Pyramidal
    EC LI-II Multipolar-Pyramidal
    EC LI-II Pyramidal-Fan
    MEC LII Oblique Pyramidal
    MEC LII Stellate
    MEC LII-III Pyramidal-Multiform
    EC LII-III Pyramidal-Tripolar
    LEC LIII Multipolar Principal
    MEC LIII Multipolar Principal
    EC LIII Small Pyramidal
    LEC LIII Complex Pyramidal
    MEC LIII Complex Pyramidal
    MEC LIII Bipolar Complex Pyramidal
    EC LIII-V Bipolar Pyramidal
    EC LIV-V Pyramidal-Horizontal
    EC LIV-VI Deep Multipolar Principal
    MEC LV Multipolar-Pyramidal
    MEC LV Principal*
    MEC LV Pyramidal
    EC LV Deep Pyramidal
    MEC LV Superficial Pyramidal
    MEC LV-VI Pyramidal-Polymorphic
    LEC LVI Multipolar-Pyramidal
    MEC LI-II Polar Interneuron*
    EC LII Axo-axonic
    MEC LII Basket
    EC LII Basket-Neurogliaform
    EC LIII Bipolar Interneuron*
    MEC LIII Multipolar Interneuron
    MEC LIII Superficial Multipolar Interneuron
    MEC LI Neurogliaform*
    EC LII-III Superficial Polymorphic Interneuron*
    EC LIII Pyramidal-Looking Interneuron
    MEC LIII Superficial Trilayered Interneuron

    Potential sources known to be avoided
    Excitatory or Inhibitory
    none known

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    DG Granule

    Potential targets
    Excitatory or Inhibitory
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy MOLDEN
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Axo-axonic GRALDEN*
    DG Basket
    DG Basket GRALDEN*
    DG Basket CCK+
    DG Interneuron Specific COLTAR*
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Interneuron Specific HIMOLD*
    DG Interneuron Specific HIPRO*
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA1 Neurogliaform Projecting
    LEC LIII Multipolar Principal
    EC LIII-V Bipolar Pyramidal
    EC LIV-V Pyramidal-Horizontal
    EC LIV-VI Deep Multipolar Principal
    MEC LV Multipolar-Pyramidal
    MEC LV Principal*
    MEC LV Pyramidal
    EC LV Deep Pyramidal
    MEC LV Superficial Pyramidal
    MEC LV-VI Pyramidal-Polymorphic
    LEC LVI Multipolar-Pyramidal
    MEC LIII Multipolar Interneuron

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value