• Browse
  • Morphology
  • Molecular markers
  • Membrane biophysics
  • Connectivity
  • Synaptic physiology
  • Firing patterns
  • Izhikevich models
  • Synapse probabilities
  • In vivo recordings
  • Cognome
  • Neuron type census
  • Simulation parameters
• Search
  • Author
  • Neuron Name/Synonym
  • Neuron Term (Neuron ID)
  • Neuron Type
  • PMID/ISBN
  • Advanced Search
• Tools
  • Connection Probabilities
  • Synapse Modelers
• Help
  • Quickstart
  • FAQ
  • Known Bugs and Issues
  • User Feedback Form
  • Other Useful Links

* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) EC (i)230000 LII Basket-Neurogliaform S110706:Perisomatic-targeting:Basket:EC Name derivation This name is a hybrid of the two most frequently cited names. Synonym(s) EC fast-spiking interneurones in layer II EC layer II fast spiking basket-like cell EC layer II fast spiking basket-like interneuron EC layer II fast spiking basket-like neuron EC layer II fast-spiking neurone EC layer II MPN LEC layer II basket cell LEC layer II multipolar cell LEC layer II multipolar neuron MEC layer II basket cell MEC layer II multipolar cell List of articles Click here to view the list Canto CB  (2008) Neural Plast What does the anatomical organization of the entorhinal cortex tell us? Canto CB, Wouterlood FG, Witter MP. Neural Plast, 2008, 2008, Pages: 381243 - PMID: 18769556; DOI: 10.1155/2008/381243 Tags: morphology, marker, connectivity, synapse probabilities Ferrante M  (2017) Cereb Cortex Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Cereb Cortex, 2017 Jun 1, 27 (6), Pages: 3186 - 3207 PMID: 27269961; DOI: 10.1093/cercor/bhw143 Tags: morphology, membrane biophysics, synapse probabilities Germroth P  (1991) J Comp Neurol Ultrastructure and aspects of functional organization of pyramidal and nonpyramidal entorhinal projection neurons contributing to the perforant path. Germroth P, Schwerdtfeger WK, Buhl EH. J Comp Neurol, 1991 Mar 8, 305 (2), Pages: 215 - 231 PMID: 2026788; DOI: 10.1002/cne.903050205 Tags: morphology Jones RS  (1993) Neurosci Lett Basket-like interneurones in layer II of the entorhinal cortex exhibit a powerful NMDA-mediated synaptic excitation. Jones RS, Buhl EH. Neurosci Lett, 1993 Jan 4, 149 (1), Pages: 35 - 39 PMID: 8469376; DOI: 10.1016/0304-3940(93)90341-H Tags: morphology, membrane biophysics Tahvildari B  (2012) J Neurosci Selective functional interactions between excitatory and inhibitory cortical neurons and differential contribution to persistent activity of the slow oscillation. Tahvildari B, Wolfel M, Duque A, McCormick DA. J Neurosci, 2012 Aug 29, 32 (35), Pages: 12165 - 79 PMID: 22933799; DOI: 10.1523/JNEUROSCI.1181-12.2012 Tags: connectivity, synapse probabilities

Morphology

Soma
	EC:II

Axons
	EC:II

Dendrites
	EC:I
	EC:II

Representative figure

Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA Cereb Cortex, 2017 Jun 1, 27 (6), pages: 3186 - 3207 PMID: 27269961; DOI: 10.1093/cercor/bhw143

"Figure 6. Intrinsic properties of NPY+ interneurons. (A1) Computer-aided 3D reconstruction of a NPY+-NGF interneuron color coded for soma (in white), dendrites (in green), and axon (in gray)."

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	CCK (subtypes)
	ENK (subtypes)
	NPY (subtypes)
	PV (subtypes)
	SOM (subtypes)
	Sub P (subtypes)
	VIP (subtypes)

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): -75.5±0.8 mV (1); 2 sources (13): [-75.5 , -61.4]
	Threshold potential (Vthresh): 32±1.4 mV (1); 2 sources (2): [3.8 , 32]
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 4.8 mV (1); 1 source
	Action potential amplitude (APampl): 64.2±1.3 mV (1); 2 sources (13): [64.2 , 69.1]
	Action potential width (APwidth): 0.99 ms (1); 2 sources (13): [0.51 , 0.99]
	Input resistance (Rin): 206±11.0 MΩ (1); 1 source
	Time constant (τm): 11.3±0.5 ms (1); 1 source

Notes

Merger approved with EC 230000 multipolar inhibitory (MPI) II neurons. Failed unofficial merger with MEC 333000 type 4 III and EC 233000 MPI 1 III. BC synapse somata of stellate II, pyramidal II, and other neurons MPI cells are inhibitory, since Germroth describes the cells as nearly spineless, which takes precedence over the fact that they are projecting (axons project to the white matter). Strong potential for future subclasses because of target specificity and because MPIs project to the hippocampus but there is no evidence that baskets do this.

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory CA2 Pyramidal EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar LEC LIII Multipolar Principal LEC LIII Complex Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal MEC LV Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* MEC LII Basket EC LII Basket-Neurogliaform MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LI Neurogliaform* EC LII-III Superficial Polymorphic Interneuron* MEC LIII Superficial Trilayered Interneuron

Potential sources known to be avoided Excitatory or Inhibitory EC LII Axo-axonic

Targets of Output

Known targets Excitatory or Inhibitory EC LI-II Pyramidal-Fan MEC LII Stellate EC LII-III Pyramidal-Tripolar

Potential targets Excitatory or Inhibitory EC LI-II Multipolar-Pyramidal MEC LII Oblique Pyramidal MEC LII-III Pyramidal-Multiform EC LIII Small Pyramidal LEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal EC LIV-V Pyramidal-Horizontal MEC LV Principal* MEC LV Pyramidal EC LV Deep Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform EC LIII Bipolar Interneuron* LEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron MEC LIII Superficial Trilayered Interneuron

Potential targets known to be avoided Excitatory or Inhibitory none known

Oscillation Phase Locking

Category

Value