MEC LV-VI Pyramidal-Polymorphic
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
MEC (e)000023 LV-VI Pyramidal-Polymorphic S081906:Glutamatergic Deep:LIV-VI:EC

Name derivation
This name is a hybrid of the two most frequently cited names. All sources indicate medial localization of the morphology.

Synonym(s)
MEC layer V polymorphic cell
MEC LVI horizontal pyramidal neuron
MEC LVI pyramidal neuron
MEC LVI tilted pyramidal neuron

List of articles
Click here to view the list
Burgalossi A  (2011) Neuron
Microcircuits of functionally identified neurons in the rat medial entorhinal cortex.
Burgalossi A, Herfst L, von Heimendahl M, Forste H, Haskic K, Schmidt M, Brecht M.
Neuron, 2011 May 26, 70 (4), Pages: 773 - 86
PMID: 21609831; DOI: 10.1016/j.neuron.2011.04.003
Tags: phases, synapse probabilities
Canto CB  (2012) Hippocampus
Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex.
Canto CB, Witter MP.
Hippocampus, 2012 Jun, 22 (6), Pages: 1277 - 1299
PMID: 22161956; DOI: 10.1002/hipo.20993
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities
Hamam BN  (2000) J Comp Neurol
Morphological and electrophysiological characteristics of layer V neurons of the rat medial entorhinal cortex.
Hamam BN, Kennedy TE, Alonso A, Amaral DG.
J Comp Neurol, 2000 Mar 20, 418 (4), Pages: 457 - 472
PMID: 10713573; DOI: 10.1002/(SICI)1096-9861(20000320)418:4<457::AID-CNE7>3.0.CO;2-L
Tags: morphology, synapse probabilities

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Rice-Baylor
    • AR-1-20-04-A (fits the general description of "MEC LV Pyramidal" or "EC LV Deep Pyramidal" or "MEC LV Superficial Pyramidal" or "MEC LV Multipolar-Pyramidal" or "MEC LV-VI Pyramidal-Polymorphic" or "EC LIV-V Pyramidal-Horizontal" based on the distribution of axons and dendrites)
    • AR-3-15-04-B (fits the general description of "MEC LV-VI Pyramidal-Polymorphic" based on the distribution of axons and dendrites)

    • Morphology
    Soma
    EC:V
    EC:VI
    Axons
    EC:VI
    Dendrites
    EC:V
    EC:VI

    Representative figure
    Morphological and electrophysiological characteristics of layer V neurons of the rat medial entorhinal cortex.
    Hamam BN, Kennedy TE, Alonso A, Amaral DG
    J Comp Neurol, 2000 Mar 20, 418 (4), pages: 457 - 472
    PMID: 10713573; DOI: 10.1002/(SICI)1096-9861(20000320)418:4<457::AID-CNE7>3.0.CO;2-L


    "Fig. 1. Morphological subtypes of entorhinal cortex layer V cells. A-C: Computer-aided reconstruction of a [A] pyramidal {EC LV Deep Pyramidal}, [B] horizontal {EC LIV-V Pyramidal-Horizontal}, and [C] polymorphic cell {MEC LV-VI Pyramidal-Polymorphic}, respectively. Dashed lines represent the borders of the indicated layers. Scale bar = 200 [micro]m."


    Molecular markers
    Positive
    None known
    Negative
    GABAa\alpha 6 (inference)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -63 mV (1); 1 source
    Input resistance (Rin): 480±93.5 MΩ (14); 1 source
    Time constant (τm): 41±18.7 ms (14); 1 source
    Threshold potential (Vthresh): [26.7, 28.7] mV (2); 1 source
    Fast afterhyperpolaziring potential amplitude (Fast AHP): [7.1, 9.1] mV (2); 1 source
    Action potential amplitude (APampl): 73±7.5 mV (14); 1 source
    Action potential width (APwidth): 2.1±0.7 ms (14); 1 source
    Max firing rate (Max F.R.): >33 Hz (1); 1 source
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 1.6 mV (1); 1 source
    Sag ratio: 0.91±0.1 (14); 1 source

    Notes
    This cell type is a result of a merger between MEC 000023 pyramidal VI and EC 000023 polymorphic V. Likely excitatory cells (Canto 201X MEC preprint -> "sparsely spiny to spiny," projecting; Hamam 2000 -> short spines, projecting). Notes on MEC 000023 pyramidal cell type: - dendrites and axons in the white matter Notes on EC 000023 polymorphic cell type: - weak evidence on axons - unclear whether dendrites project to the subiculum or to the presubiculum.

    Firing Pattern
    Images
    Image MissingImage Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]
    D.NASP [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=0.55;a= 0;b= -21.05;d= 13;C= 218;Vr= -63.16;Vt= -39.45;Vpeak= 28.82;Vmin= -51.14; Simulate
    Images
    Image Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    Sub EC-Projecting Pyramidal
    MEC LII Stellate
    MEC LII-III Pyramidal-Multiform
    MEC LIII Multipolar Principal
    EC LIII Small Pyramidal
    EC LIII-V Bipolar Pyramidal
    EC LIV-V Pyramidal-Horizontal
    EC LIV-VI Deep Multipolar Principal
    MEC LV Multipolar-Pyramidal
    MEC LV Principal*
    MEC LV Pyramidal
    EC LV Deep Pyramidal
    MEC LV Superficial Pyramidal
    MEC LV-VI Pyramidal-Polymorphic
    EC LIII Bipolar Interneuron*

    Potential sources known to be avoided
    Excitatory or Inhibitory
    LEC LIII Multipolar Principal
    LEC LIII Complex Pyramidal
    LEC LVI Multipolar-Pyramidal

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    EC LIV-V Pyramidal-Horizontal
    EC LIV-VI Deep Multipolar Principal
    EC LV Deep Pyramidal
    MEC LV-VI Pyramidal-Polymorphic

    Potential targets known to be avoided
    Excitatory or Inhibitory
    LEC LVI Multipolar-Pyramidal

    Oscillation Phase Locking
    Category
    Value