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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) LEC (i)023000 LIII Multipolar Interneuron S152006:GABAergic:iLIII:EC Name derivation "Interneuron" distinguishes this type from the multipolar pricipal cells. All sources indicate lateral localization of the morphology. Synonym(s) LEC layer III MPN LEC layer III multipolar cell LEC layer III multipolar neuron LEC layer III sparsely spinous multipolar neuron List of articles Click here to view the list Canto CB  (2008) Neural Plast What does the anatomical organization of the entorhinal cortex tell us? Canto CB, Wouterlood FG, Witter MP. Neural Plast, 2008, 2008, Pages: 381243 - PMID: 18769556; DOI: 10.1155/2008/381243 Tags: morphology, marker, connectivity, synapse probabilities Germroth P  (1991) J Comp Neurol Ultrastructure and aspects of functional organization of pyramidal and nonpyramidal entorhinal projection neurons contributing to the perforant path. Germroth P, Schwerdtfeger WK, Buhl EH. J Comp Neurol, 1991 Mar 8, 305 (2), Pages: 215 - 231 PMID: 2026788; DOI: 10.1002/cne.903050205 Tags: morphology Germroth P  (1989) Brain Res GABAergic neurons in the entorhinal cortex project to the hippocampus. Germroth P, Schwerdtfeger WK, Buhl EH. Brain Res, 1989 Aug 7, 494 (1), Pages: 187 - 192 PMID: 2765919; DOI: 10.1016/0006-8993(89)90162-5 Tags: morphology Germroth P  (1989) Neuroscience Morphology of identified entorhinal neurons projecting to the hippocampus. A light microscopical study combining retrograde tracing and intracellular injection. Germroth P, Schwerdtfeger WK, Buhl EH. Neuroscience, 1989, 30 (3), Pages: 683 - 691 PMID: 2771045; DOI: 10.1016/0306-4522(89)90161-9 Tags: morphology

Morphology

Soma
	EC:III

Axons
	EC:III

Dendrites
	EC:II
	EC:III

Molecular markers

Positive
	None known

Negative
	ENK
	GABAa\alpha 6 (inference)
	VIP

Mixed expression
	CCK (subtypes)
	SOM (subtypes)
	Sub P (subtypes)

Electrophysiological properties

None known

Notes

Failed unofficial merger proposal with EC 023100 bipolar 2 because MPI cells project to the hippocampus and there isn't evidence that these cells do that. These cells are also found in layer II Axon to hippocampus. Inhibitory because of GABA immunoreactivity and sparsely spiny dendrites.

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory CA2 Pyramidal EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan EC LII-III Pyramidal-Tripolar LEC LIII Multipolar Principal EC LIII Small Pyramidal LEC LIII Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal LEC LVI Multipolar-Pyramidal EC LII Axo-axonic EC LII Basket-Neurogliaform EC LIII Bipolar Interneuron* LEC LIII Multipolar Interneuron EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron

Potential sources known to be avoided Excitatory or Inhibitory MEC LII Oblique Pyramidal MEC LII Stellate MEC LII-III Pyramidal-Multiform MEC LIII Multipolar Principal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal MEC LV Multipolar-Pyramidal MEC LV Pyramidal MEC LV Superficial Pyramidal MEC LII Basket MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LIII Superficial Trilayered Interneuron

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory EC LII-III Pyramidal-Tripolar LEC LIII Multipolar Principal EC LIII Small Pyramidal LEC LIII Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal EC LIII Bipolar Interneuron* LEC LIII Multipolar Interneuron EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron

Potential targets known to be avoided Excitatory or Inhibitory MEC LII-III Pyramidal-Multiform MEC LIII Multipolar Principal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal MEC LV Superficial Pyramidal MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LIII Superficial Trilayered Interneuron

Oscillation Phase Locking

Category

Value