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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) MEC (i)233000 LIII Superficial Multipolar Interneuron S152006:GABAergic:iLIII:EC Name derivation All sources indicate medial localization of the morphology. Superficial distinguishes these cells from other multipolared interneurons. Multipolar is a descriptor in the cited literature and has the flavor of the standard EC naming scheme. Synonym(s) MEC layer III type I interneuron List of articles Click here to view the list Ferrante M  (2017) Cereb Cortex Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Cereb Cortex, 2017 Jun 1, 27 (6), Pages: 3186 - 3207 PMID: 27269961; DOI: 10.1093/cercor/bhw143 Tags: synapse probabilities Kumar SS  (2006) J Neurosci Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. Kumar SS, Buckmaster PS. J Neurosci, 2006 Apr 26, 26 (17), Pages: 4613 - 4623 PMID: 16641241; DOI: 10.1523/JNEUROSCI.0064-06.2006 Tags: morphology, membrane biophysics, firing patterns Middleton S  (2008) Proc Natl Acad Sci U S A NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex. Middleton S, Jalics J, Kispersky T, Lebeau FE, Roopun AK, Kopell NJ, Whittington MA, Cunningham MO. Proc Natl Acad Sci U S A, 2008 Nov 25, 105 (47), Pages: 18572 - 18577 PMID: 18997013; DOI: 10.1073/pnas.0809302105 Tags: synapse probabilities Tahvildari B  (2012) J Neurosci Selective functional interactions between excitatory and inhibitory cortical neurons and differential contribution to persistent activity of the slow oscillation. Tahvildari B, Wolfel M, Duque A, McCormick DA. J Neurosci, 2012 Aug 29, 32 (35), Pages: 12165 - 79 PMID: 22933799; DOI: 10.1523/JNEUROSCI.1181-12.2012 Tags: connectivity, synapse probabilities Supplemental PMIDs Click here to view the list of PMIDs 18997013

Morphology

Soma
	EC:III

Axons
	EC:II
	EC:III

Dendrites
	EC:I
	EC:II
	EC:III

Representative figure

Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. Kumar SS, Buckmaster PS J Neurosci, 2006 Apr 26, 26 (17), pages: 4613 - 4623 PMID: 16641241; DOI: 10.1523/JNEUROSCI.0064-06.2006

"Figure 4. Anatomical and electrophysiological features of the two dominant types of inhibitory interneurons in layer III of the medial entorhinal cortex and their excitatory synaptic drive. A, Typical biocytin-labeled type I {MEC LIII Superficial Multipolar Interneuron} and type II {MEC LIII Multipolar Interneuron} interneurons showing differences in the orientation of their dendrites (thicker branches). The axon projections (thinner branches) of the two cell types are different: confined to the vicinity of the cell body and extending into layer II for type I and projecting to and ramifying in layer I for type II (black arrowheads). Magnified views of the boxed regions are shown on the right and in insets (top) of the respective figures, illustrating dendritic spines (white arrowheads) on type II interneurons but not type I interneurons. Differences in the shape of the cell bodies are subtle but distinguishable when examined with infrared differential-interference contrast optics (top inset)."

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): -64±6.9 mV (28); 1 source
	Input resistance (Rin): 143±58.2 MΩ (28); 1 source
	Threshold potential (Vthresh): 22 mV (1); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 31±4.3 mV (11); 1 source
	Action potential amplitude (APampl): 81.2 mV (1); 1 source
	Action potential width (APwidth): 0.2 ms (11); 1 source
	Slow afterhyperpolarizing potential amplitude (Slow AHP): 4.3 mV (1); 1 source
	Sag ratio: 0.95 (1); 1 source

Notes

Failed unofficial merger proposals with MEC 333000 type 4 III and EC 230000 MPI-BC II. Inhibitory because dendrites lacked dense spines, and faster, briefer action potentials

Firing Pattern

Images

Parameters		View page
	NASP	[Evidence] [Firing Pattern]

Izhikevich Model

Parameters	Single Compartment	Downloads	Simulate
	subtype: 1 k=3.5;a= 0.172;b= -48.95;d= 295;C= 29;Vr= -62;Vt= -41.46;Vpeak= 38.89;Vmin= -67.53;	[FitFiles][CSV][XPP][Ensemble]	Simulate

Images

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory CA2 Pyramidal EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Oblique Pyramidal MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar MEC LIII Multipolar Principal EC LIII Small Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal MEC LV Multipolar-Pyramidal MEC LV Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform EC LIII Bipolar Interneuron* MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LI Neurogliaform* EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron MEC LIII Superficial Trilayered Interneuron

Potential sources known to be avoided Excitatory or Inhibitory LEC LIII Multipolar Principal LEC LIII Complex Pyramidal LEC LVI Multipolar-Pyramidal LEC LIII Multipolar Interneuron

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Oblique Pyramidal MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar MEC LIII Multipolar Principal EC LIII Small Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal EC LIV-V Pyramidal-Horizontal MEC LV Principal* MEC LV Pyramidal EC LV Deep Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform EC LIII Bipolar Interneuron* MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron MEC LIII Superficial Trilayered Interneuron

Potential targets known to be avoided Excitatory or Inhibitory LEC LIII Multipolar Principal LEC LIII Complex Pyramidal LEC LIII Multipolar Interneuron

Oscillation Phase Locking

Category

Value