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* indicates new v2.0 neuron type
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Name
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Supertype (ID:Family:Type:Subregion)
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EC (e)220033 LV Deep Pyramidal
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S081906:Glutamatergic Deep:LIV-VI:EC
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Name derivation
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This is the simplest form of the only core name in the cited literature. The descriptor is borrowed from one of the cited names to distinguish this from other layer V pyramidal cells.
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Synonym(s)
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LEC layer V pyramidal neuron
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LEC layer V small pyramidal cell
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MEC layer V pyramidal cell
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MEC layer V small pyramidal cell
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MEC LV deep pyramidal neuron
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Click here to view the list
Canto CB (2008) Neural Plast
What does the anatomical organization of the entorhinal cortex tell us? Canto CB, Wouterlood FG, Witter MP.
Neural Plast,
2008, 2008,
Pages: 381243 -
PMID: 18769556; DOI: 10.1155/2008/381243
Tags: morphology, marker, connectivity, synapse probabilities
Canto CB (2012) Hippocampus
Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex. Canto CB, Witter MP.
Hippocampus,
2012 Jun, 22 (6),
Pages: 1277 - 1299
PMID: 22161956; DOI: 10.1002/hipo.20993
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities
Hamam BN (2000) J Comp Neurol
Morphological and electrophysiological characteristics of layer V neurons of the rat medial entorhinal cortex. Hamam BN, Kennedy TE, Alonso A, Amaral DG.
J Comp Neurol,
2000 Mar 20, 418 (4),
Pages: 457 - 472
PMID: 10713573; DOI: 10.1002/(SICI)1096-9861(20000320)418:4<457::AID-CNE7>3.0.CO;2-L
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities
Hamam BN (2002) J Comp Neurol
Morphological and electrophysiological characteristics of layer V neurons of the rat lateral entorhinal cortex. Hamam BN, Amaral DG, Alonso AA.
J Comp Neurol,
2002 Sep 9, 451 (1),
Pages: 45 - 61
PMID: 12209840; DOI: 10.1002/cne.10335
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities
Mizuseki K (2009) Neuron
Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop. Mizuseki K, Sirota A, Pastalkova E, Buzsaki G.
Neuron,
2009,
Pages: 267 - 280
PMID: 19874793
Tags: phases
Mizuseki K (2011) Nat Neurosci.
Hippocampal CA1 pyramidal cells form functionally distinct sublayers. Mizuseki K, Diba K, Pastalkova E, Buzsaki G.
Nat Neurosci.,
2011,
Pages: 1174 - 1181
PMID: 21822270
Tags: phases
Quilichini P (2010) J Neurosci
Intrinsic circuit organization and theta-gamma oscillation dynamics in the entorhinal cortex of the rat. Quilichini P, Sirota A, Buzsaki G.
J Neurosci,
2010 Aug 18, 30 (33),
Pages: 11128 - 11142
PMID: 20720120; DOI: 10.1523/JNEUROSCI.1327-10.2010
Tags: phases, synapse probabilities
Surmeli G (2015) Neuron
Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal Cortex. Surmeli G, Marcu DC, McClure C, Garden DLF, Pastoll H, Nolan MF.
Neuron,
2015 Dec 2, 88,
Pages: 1040 - 1053
PMID: 26606996
Tags: connectivity, synapse probabilities
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List of Hippocampome.org to NeuroMorpho.Org mappings
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Click here to view the list of mappings
Nolan
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126-20140307e
(fits the general description of "EC LV Deep Pyramidal" based on the distribution of axons and dendrites)
Rice-Baylor
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AR-1-20-04-A
(fits the general description of "MEC LV Pyramidal" or "EC LV Deep Pyramidal" or "MEC LV Superficial Pyramidal" or "MEC LV Multipolar-Pyramidal" or "MEC LV-VI Pyramidal-Polymorphic" or "EC LIV-V Pyramidal-Horizontal" based on the distribution of axons and dendrites)
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AR-1-20-04-B
(fits the general description of "EC LV Deep Pyramidal" or "MEC LV Superficial Pyramidal" or "EC LIV-V Pyramidal-Horizontal" based on the distribution of axons and dendrites)
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AR-1-26-04-A
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more ...
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Morphological and electrophysiological characteristics of layer V neurons of the rat medial entorhinal cortex.
Hamam BN, Kennedy TE, Alonso A, Amaral DG
J Comp Neurol, 2000 Mar 20, 418 (4), pages: 457 - 472
PMID: 10713573; DOI: 10.1002/(SICI)1096-9861(20000320)418:4<457::AID-CNE7>3.0.CO;2-L
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"Fig. 1. Morphological subtypes of entorhinal cortex layer V cells. A-C: Computer-aided reconstruction of a pyramidal {EC LV Deep Pyramidal} {MEC LV-VI Pyramidal-Polymorphic}, horizontal {EC LIV-V Pyramidal-Horizontal}, and polymorphic cell, respectively. Dashed lines represent the borders of the indicated layers. Scale bar = 200 [micro]m." |
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Electrophysiological properties
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| Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max] | |
| | Resting membrane potential (Vrest): [-65.02, -64.0] mV (2); 3 sources (61): [-69 , -63.19] | | Input resistance (Rin): 605 MΩ (72); 3 sources (131): [55.14 , 605] | | Time constant (τm): 37±17.0 ms (72); 3 sources (131): [12.83 , 37] | | Threshold potential (Vthresh): 28.7 mV (1); 3 sources (3): [20.51 , 28.7] | | Fast afterhyperpolaziring potential amplitude (Fast AHP): 7.75 mV (1); 3 sources (60): [7.75 , 17.58] | | Action potential amplitude (APampl): 61 mV (72); 3 sources (131): [61 , 66.65] | | Slow afterhyperpolarizing potential amplitude (Slow AHP): 5 mV (1); 3 sources (3): [0 , 5] | | Sag ratio: 0.86 (72); 3 sources (74): [0.86 , 0.88] | | Action potential width (APwidth): 1.8 ms (72); 2 sources (110): [1.53 , 1.8] | | Max firing rate (Max F.R.): >70 Hz (1); 1 source |
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Merger with 220233 was rejected.
Likely excitatory cells (Hamam 2000 -> spiny; Hamam 2002 -> projecting, spiny; Canto 2008 -> spiny, projecting; Canto 201X MEC preprint -> projecting, "principal," sparsely spiny).
Canto & Witter 2008 schematic remains in this cell type because the authors cite Hamam in the text. Evidence for D:IV in this schematic is minimal to threshold.
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| Parameters
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Single Compartment
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Downloads
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Simulate
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| subtype: 1 k=0.21;a= 0;b= -16.14;d= 19;C= 157;Vr= -66.55;Vt= -32.89;Vpeak= 13.4;Vmin= -51.2; | | Simulate
| | subtype: 2 k=0.36;a= 0.001;b= -3.24;d= 13;C= 131;Vr= -68.47;Vt= -35.24;Vpeak= 10.74;Vmin= -53.2; | | Simulate
| | subtype: 3 k=0.4;a= 0.009;b= 5.29;d= -12;C= 56;Vr= -66.32;Vt= -31.51;Vpeak= 13.08;Vmin= -51.3; | | Simulate
| | subtype: 4 k=0.72;a= 0.01;b= 0.59;d= 159;C= 256;Vr= -66.8;Vt= -47.06;Vpeak= 3.8;Vmin= -53.12; | | Simulate
| | subtype: 5 k=1.64;a= 0.018;b= 8;d= 155;C= 486;Vr= -66.45;Vt= -47.11;Vpeak= 3.71;Vmin= -60.43; | | Simulate
| | subtype: 6 k=1.65;a= 0.008;b= 29.94;d= 36;C= 152;Vr= -66.19;Vt= -48.19;Vpeak= -4.21;Vmin= -60.27; | | Simulate
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Model Accession Number
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PubMed ID
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Potential sources known to be avoided
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Potential targets known to be avoided
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| Oscillation Phase Locking |
| Category | Value | | Theta (deg): | 0.00 | | Theta range: | [0.00, 0.00] | | Theta measurements: | 1 | | Theta representative selection: | rats, adult, male,
tetrode, freely moving | | SWR ratio: | 1.75 | | SWR ratio range: | [1.75, 1.75] | | SWR ratio measurements: | 1 | | SWR ratio representative selection: | rats, adult, male,
tetrode, freely moving | | In vivo firing rate (Hz): | 1.37 | | Firing rate range: | [1.37, 1.37] | | Firing rate measurements: | 1 | | Firing rate representative selection: | rats, adult, male,
tetrode, freely moving | | Other: | firingRateNonBaseline | | Other representative selection: | rats, adult, male,
tetrode, freely moving |
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