EC LIII Stellate
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
EC (e)223000 LIII Stellate S071806:Glutamatergic III:LIII:EC

Name derivation
This is the simplest form of the only core name in the cited literature.

Synonym(s)
LEC layer III spiny stellate cell
LEC LIII spiny stellate cell
MEC LIII SC
MEC LIII stellate cell

List of articles
Click here to view the list
Canto CB  (2012) Hippocampus
Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex.
Canto CB, Witter MP.
Hippocampus, 2012 Jun, 22 (6), Pages: 1277 - 1299
PMID: 22161956; DOI: 10.1002/hipo.20993
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities
Germroth P  (1989) Neuroscience
Morphology of identified entorhinal neurons projecting to the hippocampus. A light microscopical study combining retrograde tracing and intracellular injection.
Germroth P, Schwerdtfeger WK, Buhl EH.
Neuroscience, 1989, 30 (3), Pages: 683 - 691
PMID: 2771045; DOI: 10.1016/0306-4522(89)90161-9
Tags: morphology


Morphology
Soma
EC:III
Axons
EC:III
Dendrites
EC:I
EC:II
EC:III

Representative figure
Morphology of identified entorhinal neurons projecting to the hippocampus. A light microscopical study combining retrograde tracing and intracellular injection.
Germroth P, Schwerdtfeger WK, Buhl EH
Neuroscience, 1989, 30 (3), pages: 683 - 691
PMID: 2771045; DOI: 10.1016/0306-4522(89)90161-9


"Fig. 1. (a) Micrograph of LY[Lucifer Yellow]-filled layer (L) III pyramid {EC LIII Pyramidal} in the lateral entorhinal cortex. The arrowhead points to the descending axon. The star indicates the area enlarged in the insert at the lower left corner. Note the densely spined apical dendrite. ... c) Photomontage of L III spiny stellate cell {EC LIII Stellate}. The star marks the area enlarged in the insert. Note the spines visible on the descending dendrite. In (a) and (b) the cortical surface is parallel to the top of the figure. The position of cell (c) is close to the rhinal fissure; the cortical surface runs parallel to the top and bends down at the upper left comer of the figure."


Molecular markers
Positive
None known
Negative
GABAa\alpha 6 (inference)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): [-63.0, -59.0] mV (2); 1 source
Input resistance (Rin): 468±174.4 MΩ (76); 1 source
Time constant (τm): 43.5±17.4 ms (76); 1 source
Threshold potential (Vthresh): 19.5 mV (1); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 12.7 mV (1); 1 source
Action potential amplitude (APampl): 76±8.7 mV (76); 1 source
Action potential width (APwidth): 1.45±4.4 ms (76); 1 source
Sag ratio: 0.86 (1); 1 source

Notes
Rejected merger with EC (+)223200p Pyramidal III due to clear presence of D:IV in pyramidal III and unclear in this class. Class is a merger of 223000 Stellate and 223100 Stellate 2, which had weak axonal presence in L4

Firing Pattern
Images
Image MissingImage Missing
Parameters View page
ASP.NASP [Evidence] [Firing Pattern]
NASP [Evidence] [Firing Pattern]
RASP.ASP. [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.95;a= 0.028;b= -21.99;d= 805;C= 407;Vr= -59.01;Vt= -39.01;Vpeak= 21.51;Vmin= -38.58; Simulate
subtype: 2 k=0.53;a= 0.004;b= -0.58;d= 79;C= 749;Vr= -63.59;Vt= -38.65;Vpeak= 18.15;Vmin= -43.59; Simulate
subtype: 3 k=0.91;a= 0.069;b= 4.08;d= 45;C= 115;Vr= -58.98;Vt= -35.21;Vpeak= 21.99;Vmin= -38.94; Simulate
Images
Image MissingImage MissingImage Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
CA2 Pyramidal
EC LI-II Multipolar-Pyramidal
EC LI-II Pyramidal-Fan
MEC LII Oblique Pyramidal
MEC LII Stellate
MEC LII-III Pyramidal-Multiform
EC LII-III Pyramidal-Tripolar
LEC LIII Multipolar Principal
MEC LIII Multipolar Principal
EC LIII Small Pyramidal
LEC LIII Complex Pyramidal
MEC LIII Complex Pyramidal
MEC LIII Bipolar Complex Pyramidal
EC LIII Pyramidal
EC LIII Stellate
EC LIII-V Bipolar Pyramidal
MEC LV Multipolar-Pyramidal
MEC LV Pyramidal
MEC LV Superficial Pyramidal
LEC LVI Multipolar-Pyramidal
MEC LI-II Polar Interneuron*
EC LII Axo-axonic
MEC LII Basket
EC LII Basket-Neurogliaform
EC LIII Bipolar Interneuron*
LEC LIII Multipolar Interneuron
MEC LIII Multipolar Interneuron
MEC LIII Superficial Multipolar Interneuron
MEC LI Neurogliaform*
EC LII-III Superficial Polymorphic Interneuron*
EC LIII Pyramidal-Looking Interneuron
MEC LIII Superficial Trilayered Interneuron

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
MEC LII-III Pyramidal-Multiform
EC LII-III Pyramidal-Tripolar
LEC LIII Multipolar Principal
MEC LIII Multipolar Principal
EC LIII Small Pyramidal
LEC LIII Complex Pyramidal
MEC LIII Complex Pyramidal
MEC LIII Bipolar Complex Pyramidal
EC LIII Pyramidal
EC LIII Stellate
EC LIII-V Bipolar Pyramidal
MEC LV Superficial Pyramidal
EC LIII Bipolar Interneuron*
LEC LIII Multipolar Interneuron
MEC LIII Multipolar Interneuron
MEC LIII Superficial Multipolar Interneuron
EC LII-III Superficial Polymorphic Interneuron*
EC LIII Pyramidal-Looking Interneuron
MEC LIII Superficial Trilayered Interneuron

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value