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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) CA1 (i)0112 O-RP* S121404:O-LM Family:O-LM-like:CA1 Name derivation This name is a variant of "O-LM" since the soma and dendrites are in SO and the axons project to SR and SP. CA1 clarifies the subregion of origin, since the name is otherwise generic. Synonym(s) pH- and bupivacaine-sensitive cell OLM interneurons SOM+ interneuron List of articles Click here to view the list Chittajallu R  (2013) Nat Neurosci Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT(3A)R expression. Chittajallu R, Craig MT, McFarland A, Yuan X, Gerfen S, Tricoire L, Erkkila B, Barron SC, Lopez CM, Liang BJ, Jeffries BW, Pelkey KA, McBain CJ. Nat Neurosci, 2013 Nov, 16 (11), Pages: 1598 - 1607 PMID: 24097043; DOI: 10.1038/nn.3538 Tags: morphology, marker, membrane biophysics Torborg CL  (2006) Journal of Neuroscience TASK-like conductances are present within hippocampal CA1 stratum oriens interneuron subpopulations Torborg CL, Berg AP, Jeffries BW, Bayliss DA, McBain CJ. Journal of Neuroscience, 2006, 26 (28), Pages: 7362 - 7367 PMID: 16837582; DOI: 10.1523/JNEUROSCI.1257-06.2006 Tags: morphology Varga C  (2014) Elife Functional fission of parvalbumin interneuron classes during fast network events. LID - 10.7554/eLife.04006 [doi] Varga C, Oijala M, Lish J, Szabo GG, Bezaire M, Marchionni I, Golshani P, Soltesz I. Elife, 2014 Nov 06, 3, Pages: - PMID: 25375253; DOI: 10.7554/eLife.04006 Tags: phases, synapse probabilities Winterer J  (2019) European Journal of Neuroscience Single-cell RNA-Seq characterization of anatomically identified OLM interneurons in different transgenic mouse lines Winterer J, Lukacsovich D, Que L, Sartori AM, Luo W, Foldy C. European Journal of Neuroscience, 2019, 50 (11), Pages: 3750 - 3771 PMID: 31420995; DOI: 10.1111/ejn.14549 Tags: morphology, marker, membrane biophysics

Morphology

Soma
	CA1:SO

Axons
	CA1:SR
	CA1:SP

Dendrites
	CA1:SO

Representative figure

TASK-like conductances are present within hippocampal CA1 stratum oriens interneuron subpopulations Torborg CL, Berg AP, Jeffries BW, Bayliss DA, McBain CJ Journal of Neuroscience, 2006, 26 (28), pages: 7362 - 7367 PMID: 16837582; DOI: 10.1523/JNEUROSCI.1257-06.2006

"Figure 3. A subset of CA1 SO interneurons contain a pH and bupivacaine-sensitive current. ... C, Example neurolucida drawing of a pH- and bupivacaine-sensitive cell {CA1 O-RP*}. s.o., Stratum oriens; s.p., stratum pyramidale."

Molecular markers

Positive
	5HT-3
	AR-beta1 (inference)
	mGluR1a (inference)
	SOM (confirmed by inference)

Negative
	AR-beta2 (inference)
	CR (inference)
	ENK (multiple confirming inferences)
	ErbB4 (multiple confirming inferences)
	GABAa\alpha 6 (inference)
	MOR (multiple confirming inferences)
	PV (multiple confirming inferences)
	vGluT3 (inference)
	VIP (inference)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): -66±10.8 mV (29); 3 sources (31): [-66 , -62.38]
	Input resistance (Rin): 364±231.6 MΩ (29); 3 sources (31): [201.35 , 364]
	Time constant (τm): 38±16.2 ms (29); 1 source
	Threshold potential (Vthresh): 26±15.6 mV (29); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 21.4±6.5 mV (29); 1 source
	Action potential amplitude (APampl): 63±10.8 mV (29); 3 sources (31): [63 , 87.11]
	Action potential width (APwidth): 0.44 ms (1); 2 sources (2): [0.43 , 0.44]
	Max firing rate (Max F.R.): 53.22±4.0 Hz (1); 2 sources (2): [53.22 , 62.2]

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory CA3 Pyramidal CA3c Pyramidal CA3 Trilaminar CA2 Pyramidal CA2 Bistratified CA1 Pyramidal CA1 Deep Pyramidal CA1 Superficial Pyramidal CA1 Radiatum Giant CA1 Back-Projection CA1 Bistratified CA1 Hippocampo-subicular Projecting ENK+ CA1 Ivy CA1 Interneuron Specific LMO-O CA1 Interneuron Specific LMR-O* CA1 Recurrent O-LM CA1 Recurrent O-LMR* CA1 Interneuron Specific O-Targeting QuadD CA1 Oriens/Alveus CA1 Oriens-Bistratified CA1 Oriens-QuadA Projecting CA1 O-RPO* CA1 Quadrilaminar CA1 Interneuron Specific R-O CA1 R-RO* CA1 Interneuron Specific RO-O CA1 RP-RPO* CA1 Schaffer Collateral-Associated CA1 Schaffer Collateral-Correlated* CA1 SO-SO CA1 SO-SO Projecting* CA1 Trilaminar CA1 Radial Trilaminar EC LIII Small Pyramidal EC LIII Pyramidal

Potential sources known to be avoided Excitatory or Inhibitory none known

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory CA2 Wide-Arbor Basket CA1 Pyramidal CA1 Deep Pyramidal CA1 Superficial Pyramidal CA1 Radiatum Giant CA1 Axo-axonic CA1 Back-Projection CA1 Basket CA1 R-P Basket* CA1 Trilayer Basket* CA1 Vertical Basket* CA1 Basket CCK+ CA1 Trilayer Basket CCK+* CA1 Bistratified CA1 RO-receiving CA3-targeting* CA1 Hippocampo-subicular Projecting ENK+ CA1 Ivy CA1 LMR CA1 LMR-LM* CA1 Interneuron Specific LMR-O* CA1 LMR-R* CA1 Interneuron Specific LMR-R CA1 LMR Projecting CA1 Interneuron Specific O-Targeting QuadD CA1 Oriens/Alveus CA1 OR-LM CA1 Perforant Path-Associated CA1 Perforant Path-Associated QuadD CA1 QuadD-RP* CA1 Quadrilaminar CA1 Interneuron Specific R-O CA1 R-Receiving Apical-Targeting CA1 R-RO* CA1 R-RP* CA1 Radiatum CA1 Interneuron Specific RO-O CA1 Interneuron Specific RO-R* CA1 RO-RP* CA1 RP-RPO* CA1 Schaffer Collateral-Associated CA1 Schaffer Collateral-Correlated* CA1 Schaffer Collateral-Receiving R-Targeting CA1 Radial Trilaminar

Potential targets known to be avoided Excitatory or Inhibitory none known

Oscillation Phase Locking

Category

Value