Neuron type - CA1 RO-receiving CA3-targeting*

		* indicates new v2.0 neuron type
Name		Supertype (ID:Family:Type:Subregion)
	CA1 (i)0202p-CA3_00010 RO-receiving CA3-targeting*	S131504:Collateral-related:RO-targeting:CA1

Name derivation
	This name is derived from the general description of its axonal-dendritic patterning and targeting. CA1 distinguishes these cells from cells in other subregions.

Synonym(s)
	CA1 CRH neuron

List of articles

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Hooper A (2016) Hippocampus

Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone
Hooper A, Maguire J.
Hippocampus, 2016, 26 (1), Pages: 41 - 53
PMID: 26135556; DOI: 10.1002/hipo.22487
Tags: morphology, marker, membrane biophysics

Morphology

Soma
	CA1:SP

Axons
	CA3:SP

Dendrites
	CA1:SR
	CA1:SO

Representative figure

Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone
Hooper A, Maguire J
Hippocampus, 2016, 26 (1), pages: 41 - 53
PMID: 26135556; DOI: 10.1002/hipo.22487

"FIGURE 1. Characterization of hippocampal CRH [corticotropin-releasing hormone] neurons. ... a1, Higher magnification of the CA1 pyramidal cell layer highlights the morphology of hippocampal CRH neurons {CA1 RO-receiving CA3-targeting*}. a2, Higher magnification of the CA3 subregion of the hippocampus reveals dense GFP- expressing terminals surrounding the principal neurons."

Molecular markers

Positive
	CB
	CB1 (inference)
	CCK (confirmed by inference)
	CR
	CRH
	mGluR1a (inference)
	SOM (confirmed by inference)

Negative
	5HT-3 (inference)
	AR-beta2 (multiple confirming inferences)
	ENK (inference)
	ErbB4 (multiple confirming inferences)
	GABAa\alpha 6 (inference)
	Gaba-a-alpha (multiple confirming inferences)
	MOR (multiple confirming inferences)
	PV (confirmed by inference)
	vGluT2
	vGluT3 (multiple confirming inferences)
	VIP (multiple confirming inferences)

Mixed expression
	AR-beta1 (inferential conflict likely due to subtypes)

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

	Resting membrane potential (V_rest): -57.7±3.2 mV (1); 1 source
	Input resistance (R_in): 32.1±3.9 MΩ (1); 1 source
	Threshold potential (V_thresh): 13.7±4.3 mV (1); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 18.4±1.9 mV (1); 1 source
	Action potential amplitude (AP_ampl): 63.9±3.8 mV (1); 1 source

Notes

CA1 (i)0202p-CA3_00010 RO-receiving CA3-taregting neurons [4173]

                                        Related types:
                                

                                        no matching patterns
                                

Notes:

GAD67+. PV-. some SOM+. some CR+. some CB+. FP. Ephys.

(SOM/CR)-. (SOM/CB)-. (CR/CB)-.

OK - KM 04/14/2018

Previously this packet was mistakenly submitted for vetting as an on-hold cell type. It is now under re-consideration as an active cell type. - 05/02/2018

The axonal morphology is not very clear to me based on current evidence. I am not sure about making this packet active in the absence of a real reconstruction using intracellular labeling. Are these neurons even GABAergic or Glutamatergic? - KM 05/24/2018

                                        The abstract describes them as a novel subtype of interneuron expressing both GABA and GAD67. I am still in favor of making this novel type of neuron active. - DWW 06/05/2018
                                

                                        I think there's enough evidence to make it active. OK - GAA 07/18/2018
                                

                                        OK - GAA
                                

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources

Excitatory or Inhibitory

none known

Potential sources

Excitatory or Inhibitory

	CA3 Pyramidal
	CA3c Pyramidal
	CA3c Umbrella Pyramidal*
	CA3 Trilaminar
	CA2 Pyramidal
	CA2 Bistratified
	CA1 Pyramidal
	CA1 Deep Pyramidal
	CA1 Superficial Pyramidal
	CA1 Radiatum Giant
	CA1 Back-Projection
	CA1 Bistratified
	CA1 Hippocampo-subicular Projecting ENK+
	CA1 Ivy
	CA1 Interneuron Specific LM-R
	CA1 Interneuron Specific LMO-O
	CA1 LMR
	CA1 Interneuron Specific LMR-O*
	CA1 LMR-R*
	CA1 Interneuron Specific LMR-R
	CA1 LMR Projecting
	CA1 Recurrent O-LM
	CA1 O-LMR
	CA1 Recurrent O-LMR*
	CA1 Interneuron Specific O-R
	CA1 O-RP*
	CA1 Interneuron Specific O-Targeting QuadD
	CA1 Oriens/Alveus
	CA1 Oriens-Bistratified
	CA1 Oriens-QuadA Projecting
	CA1 O-RPO*
	CA1 QuadD-RP*
	CA1 Quadrilaminar
	CA1 Interneuron Specific R-O
	CA1 R-Receiving Apical-Targeting
	CA1 R-RO*
	CA1 R-RP*
	CA1 Radiatum
	CA1 Interneuron Specific RO-O
	CA1 Interneuron Specific RO-R*
	CA1 RO-RP*
	CA1 RP-RPO*
	CA1 Schaffer Collateral-Associated
	CA1 Schaffer Collateral-Correlated*
	CA1 Schaffer Collateral-Receiving R-Targeting
	CA1 SO-SO
	CA1 SO-SO Projecting*
	CA1 Trilaminar
	CA1 Radial Trilaminar
	Sub CA1-Projecting Pyramidal
	EC LIII Small Pyramidal
	EC LIII Pyramidal

Potential sources known to be avoided

Excitatory or Inhibitory

none known

Targets of Output

Known targets

Excitatory or Inhibitory

none known

Potential targets

Excitatory or Inhibitory

	CA3 Pyramidal
	CA3c Pyramidal
	CA3c Umbrella Pyramidal*
	CA3 Axo-axonic
	CA3 Basket
	CA3 Basket CCK+
	CA3 Mossy Fiber-Associated Basket CCK+*
	CA3 Bistratified
	CA3 Ivy
	CA3 Bilayer Ivy*
	CA3 Spiny Lucidum
	CA3 Mossy Fiber-Associated
	CA3 Mossy Fiber-Associated ORDEN
	CA3 Interneuron Specific Quad
	CA3 QuadD-LM
	CA2 Wide-Arbor Basket

Potential targets known to be avoided

Excitatory or Inhibitory

none known

Oscillation Phase Locking