CA1 Recurrent O-LMR*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)1103 Recurrent O-LMR* S121404:O-LM Family:O-LM-like:CA1

Name derivation
The "R" modifies the only name in the cited literature and distinguishes this cell from the canonical CA1 O-LM cell and from the variant with a recurrent axon in SO. SLM comes before SR in HC ordering of the layers. This O-LM cell has a recurrent collateral that re-invades SO that distinguishes it from the CA1 O-LMR cell. CA1 distinguishes these cells from O-LM cells in other subregions. O-LMR stands for "Oriens (dendrites) - Lacunosum-Moleculare Radiatum (axons)."

Synonym(s)
CA1 O-LM cell
CA1 interneuron innervating stratum radiatum
CA1 O-LM interneuron

List of articles
Click here to view the list
Chittajallu R  (2013) Nat Neurosci
Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT(3A)R expression.
Chittajallu R, Craig MT, McFarland A, Yuan X, Gerfen S, Tricoire L, Erkkila B, Barron SC, Lopez CM, Liang BJ, Jeffries BW, Pelkey KA, McBain CJ.
Nat Neurosci, 2013 Nov, 16 (11), Pages: 1598 - 1607
PMID: 24097043; DOI: 10.1038/nn.3538
Tags: morphology, marker
Forro T  (2015) Cerebral Cortex
Temporal Organization of GABAergic Interneurons in the Intermediate CA1 Hippocampus During Network Oscillations
Forro T, Valenti O, Lasztoczi B, Klausberger T.
Cerebral Cortex, 2015, Pages: 1228 - 1240
PMID: 24275828
Tags: morphology, marker, phases
Quattrocolo G  (2013) J Neurosci
Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.
Quattrocolo G, Maccaferri G.
J Neurosci, 2013 Mar 27, 33 (13), Pages: 5486 - 5498
PMID: 23536064; DOI: 10.1523/JNEUROSCI.5680-12.2013
Tags: morphology, marker, connectivity, synapse probabilities
Svoboda KR  (1999) J Neurosci
Opioid receptor subtype expression defines morphologically distinct classes of hippocampal interneurons.
Svoboda KR, Adams CE, Lupica CR.
J Neurosci, 1999 Jan 1, 19 (1), Pages: 85 - 95
PMID: 9870941
Tags: morphology, marker, connectivity, synapse probabilities
Varga C  (2012) Proc Natl Acad Sci U S A
Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice.
Varga C, Golshani P, Soltesz I.
Proc Natl Acad Sci U S A, 2012, Pages: 2726 - 2734
PMID: 23010933
Tags: phases

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings

Morphology
Soma
CA1:SO
Axons
CA1:SLM
CA1:SR
CA1:SO
Dendrites
CA1:SO

Representative figure
Temporal Organization of GABAergic Interneurons in the Intermediate CA1 Hippocampus During Network Oscillations
Forro T, Valenti O, Lasztoczi B, Klausberger T
Cerebral Cortex, 2015, pages: 1228 - 1240
PMID: 24275828;


"Figure 4. Visualization, molecular expression, and in vivo fi ring patterns of the identified iCA1 O-LM cell TF12b. (A) Reconstruction {CA1 Recurrent O-LMR*} of axons (blue, from 1 section, boutons represented by blue spheres) and soma and dendrites (red, complete from 9 consecutive sections)."


Molecular markers
Positive
AR-beta1 (inference)
mGluR1a (confirmed by inference)
mGluR7a
MOR
SOM (confirmed by inference)
Negative
AR-beta2 (inference)
CB1 (multiple confirming inferences)
CCK (multiple confirming inferences)
CR (multiple confirming inferences)
ENK (multiple confirming inferences)
ErbB4 (multiple confirming inferences)
GABAa\alpha 6 (inference)
PV (multiple confirming inferences)
vGluT3 (multiple confirming inferences)
VIP (inference)
Mixed expression
5HT-3 (subtypes)

Electrophysiological properties
None known

Notes

CA1 (i) 1113 Recurrent O-LMR neurons

Notes:

N = 2

DWW 02/16/2015

CLR 02/17/2015

CW 02/18/2015

OK. Name: recurrent O-LMR? - GAA

CA1 (i)1103 Recurrent O-LMR (Recurr O-LMR) neurons

Related types: CA1 (i)1113 Recurrent O-LMRP (v2.0 active)
CA1 (i)1112 O-LMRP (v2.0 on-hold)
CA1 (i)1102 O-LMR (v1.0 active)
CA1 (i)1003 Recurrent O-LM (v1.0 active)
CA1 (i)1002 O-LM (v1.0 active)

Notes:

mGluR1α+. SOM+.

A:SLM_SR_SO boutons.

The Svoboda cell is currently on-hold.

Approved as CA1 1103. This fits with my comments on HIPP cells in the previous round of packets. - CLR 03/28/2017

Approved by DWW and KM - 06/21/2017

Need 1113 packet comparison
Svoboda might be O-Bi? - GAA 10/03/2017

These 1103 cells have scant presence in SP, whereas the 1113 cells have multiple A's that branch and terminate in SP.

Can we create a single packet between 1113 & 1103? - GAA 10/10/2017

CA1 (i)1103 Recurrent O-LMR (Recurr O-LMR) neurons [4146]

Related types: CA1 (i)1112 O-LMRP (v2.0 on-hold)
CA1 (i)1102 O-LMR (v1.0 active)
CA1 (i)1003 Recurrent O-LM (v1.0 active)
CA1 (i)1002 O-LM (v1.0 active)

Notes:

mGluR1α+. SOM+.

A:SLM_SR_SO boutons.

The Svoboda cell is currently on-hold.

The Quattrocolo and Chittajallu cells were previously interpreted as 1113.

Can we create a single packet between 1113 & 1103? - GAA 10/10/2017

KM blindly reviewed all 4 cells in question and interpreted all 4 as 1103. - DWW 10/11/2017

The former 1113 packet has now been merged with the cells in this 1103 packet.


Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
CA3 Pyramidal
CA3c Pyramidal
CA3 Trilaminar
CA2 Pyramidal
CA2 Bistratified
CA1 Pyramidal
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Radiatum Giant
CA1 Back-Projection
CA1 Bistratified
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LMO-O
CA1 Interneuron Specific LMR-O*
CA1 Recurrent O-LM
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 O-RPO*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-RO*
CA1 Interneuron Specific RO-O
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar
EC LIII Small Pyramidal
EC LIII Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
CA1 Pyramidal
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Cajal-Retzius
CA1 Local-Projecting Cajal-Retzius*
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Horizontal Axo-axonic
CA1 Back-Projection
CA1 Basket
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 RO-receiving CA3-targeting*
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Neurogliaform
CA1 Neurogliaform Projecting
CA1 O-LM
CA1 Recurrent O-LM
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 OR-LM
CA1 O-RPO*
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value
Theta (deg):176.56
Theta range:[136.95, 219.53]
Theta measurements:6
Theta representative selection:   mice, adult, unknown sex,
juxtacellular, head-fixed awake
SWR ratio:2.44
SWR ratio range:[2.44, 2.44]
SWR ratio measurements:1
SWR ratio representative selection:   mice, adult, unknown sex,
juxtacellular, head-fixed awake
In vivo firing rate (Hz):10.40
Firing rate range:[5.05, 19.07]
Firing rate measurements:7
Firing rate representative selection:   mice, adult, unknown sex,
juxtacellular, head-fixed awake
Other:ripple and 4 others
Other representative selection:   mice, adult, unknown sex,
juxtacellular, head-fixed awake