CA1 R-P Basket*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)0210 R-P Basket* S110704:Perisomatic-targeting:Basket:CA1

Name derivation
CA1 distinguishes these cells from basket cells in other subregions. The modifier is a variant of "O-LM" because the dendrites are in SR and the axons project to SP.

Synonym(s)
CA1 FS basket cell
CA1 basket cell
CA1 PV interneuron

List of articles
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Bell LA  (2015) Journal of Physiology
Activation of muscarinic receptors by ACh release in hippocampal CA1 depolarizes VIP but has varying effects on parvalbumin-expressing basket cells
Bell LA, Bell KA, McQuiston AR.
Journal of Physiology, 2015, 593 (1), Pages: 197 - 215
PMID: 25556796; DOI: 10.1113/jphysiol.2014.277814
Tags: morphology, marker
Evstratova A  (2011) J Physiol
Cell type-specific and activity-dependent dynamics of action potential-evoked Ca2+ signals in dendrites of hippocampal inhibitory interneurons
Evstratova A, Chamberland S, Topolnik L.
J Physiol, 2011, 589 (Pt 8), Pages: 1957 - 1977
PMID: 21486769; DOI: 10.1113/jphysiol.2010.204255
Tags: morphology
Mendez P  (2012) Journal of Neuroscience
Direct alteration of a specific inhibitory circuit of the hippocampus by antidepressants
Mendez P, Pazienti A, Szabo G, Bacci A.
Journal of Neuroscience, 2012, 32 (47), Pages: 16616 - 16628
PMID: 23175817; DOI: 10.1523/JNEUROSCI.1720-12.2012
Tags: morphology, marker

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Bacci
    • C81113 (Fig 4A)
    • D90203 (fits the general description of "CA1 R-P Basket" or "CA1 Basket" or "CA1 Trilayer Basket" or "CA1 Horizontal Basket" based on the distribution of axons and dendrites)
    • E091118 (fits the general description of "CA1 R-P Basket" or "CA1 Horizontal Basket" based on the distribution of axons and dendrites)
    • more ...
  • McBain
  • McQuiston

    • Morphology
    Soma
    CA1:SR
    CA1:SP
    Axons
    CA1:SP
    Dendrites
    CA1:SR

    Representative figure
    Direct alteration of a specific inhibitory circuit of the hippocampus by antidepressants
    Mendez P, Pazienti A, Szabo G, Bacci A
    Journal of Neuroscience, 2012, 32 (47), pages: 16616 - 16628
    PMID: 23175817; DOI: 10.1523/JNEUROSCI.1720-12.2012


    "Figure4. Antidepressants reduce unitary synaptic responses from FS [fast-spiking] but not from CB1R+ basket cells. A, B, Top, Current-clamp recordings showing the firing characteristics of two interneuron types in response to current injections. Note the FS (blue traces) {CA1 R-P Basket*} and RS [regular-spiking] (red traces) behaviors. Bottom, Anatomical reconstructions of the same interneurons. Blue and Red Tracings, Axonal projections of the FS and RS cell, respectively. Black Tracings, Somatodendritic compartments of both cells. Note that the axon is mainly confined to the stratum pyramidale (s.p.) in both cell types, identifying them as basket cells. Scale bar: 200 [micro]m."


    Molecular markers
    Positive
    AR-beta1 (inference)
    Gaba-a-alpha (multiple confirming inferences)
    Mus2R
    PV
    Negative
    5HT-3 (inference)
    CB (multiple confirming inferences)
    CB1 (confirmed by inference)
    CCK (multiple confirming inferences)
    Chrna2 (inference)
    CR (multiple confirming inferences)
    ENK (multiple confirming inferences)
    GABAa\alpha 6 (inference)
    mGluR1a (inference)
    MOR (inference)
    NPY (multiple confirming inferences)
    SOM (multiple confirming inferences)
    vGluT3 (multiple confirming inferences)
    VIP (multiple confirming inferences)
    Mixed expression
    None known

    Electrophysiological properties
    None known

    Notes

    CA1 (i)0210 R-P Basket cells (R-P BC) [4145]

    Related types: CA1 (i)0230 RP-P BC CCK+ (v2.0 unapproved on-hold)
    CA1 (i)0211 R-PO BC CCK+ (v2.0 unapproved on-hold)
    CA1 (i)0210 R-P BC CCK+ (v2.0 unapproved on-hold)

    Notes: These cells are tagged either as CB1R-, PV+, or they do not report their associated markers at all, which differentiates these cells from the CCK+ cells. These cells lack a D presence in SP, which the 0230 cell exhibits. This cell lacks A penetrating deep into So, which the 0211 cell has.

    Firing pattern. CB1R-. PV+.

    Méndez cell is currently on-hold.

    p9 → CA1:0330 - KM 11/29/2017

    One of the Evstratova 2011 cells has been moved to a 0330 packet. - 12/05/2017

    Approved - GAA 12/12/2017


    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    CA3 Pyramidal
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Bistratified
    CA1 Back-Projection
    CA1 Bistratified
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LM-R
    CA1 LMR
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 O-RPO*
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 Trilaminar
    CA1 Radial Trilaminar
    Sub CA1-Projecting Pyramidal
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    CA2 Wide-Arbor Basket
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 Ivy
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 RP-RPO*
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value