CA1 LMR-R*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)2300 LMR-R* S131504:Collateral-related:RO-targeting:CA1

Name derivation
This name is a variant of "O-LM" since the dendrites are in SLM and SR and the axons project to SR. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 L-H-R
CA1 stratum radiatum interneuron
CA1 SCA

List of articles
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Ali AB  (2010) Eur J Neurosci
Asynchronous release of GABA via tonic cannabinoid receptor activation at identified interneuron synapses in rat CA1.
Ali AB, Todorova M.
Eur J Neurosci, 2010 Apr, 31 (7), Pages: 1196 - 1207
PMID: 20345910; DOI: 10.1111/j.1460-9568.2010.07165.x
Tags: morphology
Ali AB  (2011) J Neurophysiol
CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
Ali AB.
J Neurophysiol, 2011 Mar, 105 (3), Pages: 1051 - 1062
PMID: 21123660; DOI: 10.1152/jn.00831.2010
Tags: morphology, marker, connectivity, synapse probabilities
Leao RN  (2012) Nat Neurosci
OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
Leao RN, Mikulovic S, Leao KE, Munguba H, Gezelius H, Enjin A, Patra K, Eriksson A, Loew LM, Tort AB, Kullander K.
Nat Neurosci, 2012 Nov, 15 (11), Pages: 1524 - 1530
PMID: 23042082; DOI: 10.1038/nn.3235
Tags: morphology, marker, connectivity, synapse probabilities
Parra P  (1998) Neuron
How many subtypes of inhibitory cells in the hippocampus?
Parra P, Gulyas AI, Miles R.
Neuron, 1998 May, 20 (5), Pages: 983 - 993
PMID: 9620702
Tags: morphology

Supplemental PMIDs
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List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • McBain
    • 2009-12-09-3 (fits the general description of "CA1 LMR-R" based on the distribution of axons and dendrites)

    • Morphology
    Soma
    CA1:SLM
    CA1:SR
    Axons
    CA1:SR
    Dendrites
    CA1:SLM
    CA1:SR

    Molecular markers
    Positive
    CB1 (inference)
    CCK (confirmed by inference)
    Negative
    AR-beta1 (multiple confirming inferences)
    Chrna2 (inference)
    CR (multiple confirming inferences)
    ENK (multiple confirming inferences)
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (inference)
    mGluR1a (inference)
    MOR (multiple confirming inferences)
    NPY (inference)
    PV (multiple confirming inferences)
    SOM (multiple confirming inferences)
    VIP
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Input resistance (Rin): 220±9.0 MΩ (1); 1 source
    Time constant (τm): 42.6±1.9 ms (1); 1 source
    Action potential width (APwidth): 1.1±0.1 ms (1); 1 source
    Max firing rate (Max F.R.): 52±4.0 Hz (1); 1 source

    Notes

    CA1 (i)2300 LMR-R neurons [4107]

    Related types: CA1 (i)2300 Interneuron Specific LMR-R (v1.0 active)

    Notes: This packet is separate from CA1 (i)2300 (0SS0) Interneuron Specific LMR-R because the specificity for interneurons is not mentioned and the data suggest the type is VIP-.

    Ali (2011) added - 02/24/2015

    Ali (2010) added - 02/25/2015

    I approve this neuron type and the addition of the Ali 2010 neuron to this packet. - CW 02/26/2015

    I would like to discuss this one. - GAA

    I do not remember what Giorgio had to say about this packet. It seems reasonably straightforward and must be kept separate from the IS packet. - DWW 09/10/2015

    I have no further comments until we know Giorgio's objections. - CW 09/23/2015

    Let's ask GAA. CLR 10/10/15

    "VIP-" where? how about CR? in light of the Science paper it makes me pause but I guess OK - GAA 11/29/2015

    There is no mention in any of the references about CR expression.


    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    DG Local-Projecting Cajal-Retzius*
    CA3 Pyramidal
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Bistratified
    CA1 Cajal-Retzius
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Back-Projection
    CA1 Bistratified
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LM-R
    CA1 LMR
    CA1 LMR-LM*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 Neurogliaform
    CA1 Neurogliaform Projecting
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 Trilaminar
    CA1 Radial Trilaminar
    Sub CA1-Projecting Pyramidal
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    none known

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Radiatum Giant
    CA1 Axo-axonic
    CA1 Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 RO-receiving CA3-targeting*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 LMR
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 OR-LM
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value