CA1 R-RO*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)0301 R-RO* S131504:Collateral-related:RO-targeting:CA1

Name derivation
This name is a variant of "O-LM" since the dendrites are in SO and the axons project to SR and SO. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 R-OR
CA1 non-basket cell (CBIR+)
CA1 CCK-SCA

List of articles
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Cea-del Rio CA  (2011) J Physiol
Cholinergic modulation amplifies the intrinsic oscillatory properties of CA1 hippocampal cholecystokinin-positive interneurons.
Cea-del Rio CA, Lawrence JJ, Erdelyi F, Szabo G, McBain CJ.
J Physiol, 2011 Feb 1, 589 (Pt 3), Pages: 609 - 627
PMID: 21115639; DOI: 10.1113/jphysiol.2010.199422
Tags: morphology, membrane biophysics
Cossart R  (2006) Hippocampus
Interneurons targeting similar layers receive synaptic inputs with similar kinetics
Cossart R, Petanjek Z, Dumitriu D, Hirsch JC, Ben-Ari Y, Esclapez M, Bernard C.
Hippocampus, 2006, 16 (4), Pages: 408 - 420
PMID: 16435315; DOI: 10.1002/hipo.20169
Tags: morphology
Nissen W  (2010) J Neurosci
Cell type-specific long-term plasticity at glutamatergic synapses onto hippocampal interneurons expressing either parvalbumin or CB1 cannabinoid receptor.
Nissen W, Szabo A, Somogyi J, Somogyi P, Lamsa KP.
J Neurosci, 2010 Jan 27, 30 (4), Pages: 1337 - 1347
PMID: 20107060; DOI: 10.1523/JNEUROSCI.3481-09.2010
Tags: morphology, marker
Winterer J  (2011) Journal of Neuroscience
Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus
Winterer J, Stempel AV, Dugladze T, Foldy C, Maziashvili N, Zivkovic AR, Priller J, Soltesz I, Gloveli T, Schmitz D.
Journal of Neuroscience, 2011, 31 (23), Pages: 8464 - 8475
PMID: 21653851; DOI: 10.1523/JNEUROSCI.6382-10.2011
Tags: morphology, marker

Supplemental PMIDs
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List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Esclapez
  • McBain
    • 2009-12-09-5 (fits the general description of "CA1 R-RO" based on the distribution of axons and dendrites)
  • Schmitz

    • Morphology
    Soma
    CA1:SR
    Axons
    CA1:SR
    CA1:SO
    Dendrites
    CA1:SR

    Representative figure
    Cell type-specific long-term plasticity at glutamatergic synapses onto hippocampal interneurons expressing either parvalbumin or CB1 cannabinoid receptor.
    Nissen W, Szabo A, Somogyi J, Somogyi P, Lamsa KP
    J Neurosci, 2010 Jan 27, 30 (4), pages: 1337 - 1347
    PMID: 20107060; DOI: 10.1523/JNEUROSCI.3481-09.2010


    "Figure 2. LTP is specific to perisomatic-targeting PV+ cell types. EPSPs in PV+ bistratified cells that target to the dendritic domain of CA1 pyramidal cells show LTD. EPSPs in interneurons that express CB1R and innervate pyramidal cell dendrites show no lasting plasticity. Perforated patch (PP) recordings. ... D, Visualization of a CB1R+ non-basket cell {CA1 R-RO*} (k270582, reconstruction from two 70-[micro]m-thick sections), recorded in perforated and whole-cell mode. Axon ramifies in strata oriens and radiatum but not in pyramidale. It was verified that the main axon originated 55 [micro]m away from the soma at a point at which the dendrite turned by 90” degrees. Scale bar, 100 [micro]m."


    Molecular markers
    Positive
    CB1
    CCK
    NPY
    Negative
    PV
    SOM
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Input resistance (Rin): 220±9.0 MΩ (1); 1 source
    Time constant (τm): 42.6±1.9 ms (1); 1 source
    Action potential width (APwidth): 1.1±0.1 ms (1); 1 source
    Max firing rate (Max F.R.): 52±4.0 Hz (1); 1 source

    Notes

    CA1 (i)0301 R-RO neurons [4100]

    Related types: CA1 (i)0331 RP-RPO (v2.0 active)

    Notes:

    N = 7

    - Add caption for Fig. 1
    - Consider not including the second figure in the X-O/R panel. The axons in SP look sparse. - CW 02/11/2015

    - The axons look no sparser than those in SR or those in SP in the other panel, so I would keep the current interpretation. - DWW 02/12/2015

    - Looks good. [Consider merging with 0311] - GAA

    Cells reinterpreted due to new understanding of Cossart interpretations. type was 0331, but is now 0301. - 07/20/2015

    Nissen (2010) added - 07/20/2015

    DWW 09/03/2015

    I support all of these aggressive mergers and sign off on the packets. - CLR 09/08/2015

    okay - CW 09/08/2015

    OK. Strong candidate for superclass with 0331 ... - GAA 11/29/2015

    The cell by Cea-del Rio et al., 2011 (on second look, it might be a 0301) - DWW 11/16/2021

    I'm in agreement with your second look ā?? this appears to be a 0301. I do not have access to the 0301 type packet (CA1 R-RO), but we could add these biophysics values for this type.
    After review of the R-RO packet, I am in favor of adding the ephys information for the Cea-del Rio et al., 2011 cell to the CA1 R-RO neuron type. - JDK 11/17/2021

    Cea-del Rio et al., 2011, is being added to this packet to take advantage of its reported membrane biophysics. - 11/19/2021

    I approve the addendum but would like to consider a merger with 0331. - GAA 02/01/2022

    The difficulty with merging the 0301 and 0331 cells lies with the cells from Cossart et al., 2006: "The major difference is that X-OPR [0331] cell axons display boutons en passant within stratum pyramidale while X-OR [0301] cell axons do not. Therefore, X-OPR and X-OR cells belong to two different morphological families." - DWW 02/03/2022

    In addition to the description from Cossart et al., 2006, another consideration with this merger is that only two of the 9 cells (R-OR 172T1 of Cossart et al., 2006 and the cell in Cea-del Rio et al., 2011) I could see meeting the criteria of having dendrites in SP. We'd need dendritic along with axonal presence for this merger to occur, which I currently donā??t think from the provided packet we have. I am open to discussing further though! - JDK 02/03/2022

    IWith those clarifications added, Iā??m ok to (re-)approve both packets. Thanks! - GAA 02/03/2022

    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    CA3 Pyramidal
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Bistratified
    CA1 Back-Projection
    CA1 Bistratified
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LM-R
    CA1 LMR
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 O-RPO*
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 Trilaminar
    CA1 Radial Trilaminar
    Sub CA1-Projecting Pyramidal
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    none known

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Radiatum Giant
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Horizontal Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 RO-receiving CA3-targeting*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 LMR
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value