Neuron type - CA1 Cajal-Retzius

		* indicates new v2.0 neuron type
Name		Supertype (ID:Family:Type:Subregion)
	CA1 (e)3000 Cajal-Retzius	S030304:Glutamatergic C-R:Cajal-Retzius:CA1

Name derivation
	This is the only name in the cited literature.

Synonym(s)
	CA1 Cajal-Retzius

List of articles

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Anstotz M (2013) Brain Struct Funct

Morphology, input-output relations and synaptic connectivity of Cajal-Retzius cells in layer 1 of the developing neocortex of CXCR4-EGFP mice.
Anstotz M, Cosgrove KE, Hack I, Mugnaini E, Maccaferri G, Lubke JH.
Brain Struct Funct, 2013 Sep 12, 219 (6), Pages: 2119 - 2139
PMID: 24026287; DOI: 10.1007/s00429-013-0627-2
Tags: morphology

Quattrocolo G (2013) J Neurosci

Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.
Quattrocolo G, Maccaferri G.
J Neurosci, 2013 Mar 27, 33 (13), Pages: 5486 - 5498
PMID: 23536064; DOI: 10.1523/JNEUROSCI.5680-12.2013
Tags: morphology, membrane biophysics, connectivity, firing patterns, synapse probabilities

Quattrocolo G (2014) J Neurosci

Optogenetic activation of cajal-retzius cells reveals their glutamatergic output and a novel feedforward circuit in the developing mouse hippocampus.
Quattrocolo G, Maccaferri G.
J Neurosci, 2014 Sep 24, 34 (39), Pages: 13018 - 13032
PMID: 25253849; DOI: 10.1523/JNEUROSCI.1407-14.2014
Tags: morphology, marker, membrane biophysics, connectivity, firing patterns, synapse probabilities

Morphology

Soma
	CA1:SLM

Axons
	CA1:SLM

Dendrites
	CA1:SLM

Representative figure

Optogenetic activation of cajal-retzius cells reveals their glutamatergic output and a novel feedforward circuit in the developing mouse hippocampus.
Quattrocolo G, Maccaferri G
J Neurosci, 2014 Sep 24, 34 (39), pages: 13018 - 13032
PMID: 25253849; DOI: 10.1523/JNEUROSCI.1407-14.2014

"Figure 2. Optogenetically triggered firing in Cajal-Retzius cells {CA1 Cajal-Retzius}. A, Camera lucida tracing of whole-cell, biocytin-filled, EYFP-expressing neurons of stratum lacunosum-moleculare reveals the typical features of Cajal-Retzius (l-m, stratum lacunosum-moleculare)."

Molecular markers

Positive
	CR
	CXCR4
	RLN

Negative
	AR-beta1 (inference)
	AR-beta2 (inference)
	CB (multiple confirming inferences)
	CB1 (multiple confirming inferences)
	CCK (multiple confirming inferences)
	Chrna2 (inference)
	GABAa\alpha 6 (inference)
	mGluR1a (inference)
	MOR (multiple confirming inferences)
	PV (multiple confirming inferences)
	SOM (multiple confirming inferences)
	vGluT3 (multiple confirming inferences)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

	Threshold potential (V_thresh): [22, 37] mV (2); 2 sources (4): [22 , 24]
	Fast afterhyperpolaziring potential amplitude (Fast AHP): [12, 19] mV (2); 2 sources (4): [12 , 24]
	Action potential amplitude (AP_ampl): [7.7, 50.6] mV (2); 2 sources (4): [7.7 , 20]
	Slow afterhyperpolarizing potential amplitude (Slow AHP): 0.2 mV (1); 2 sources (2): [0.2 , 1.6]
	Sag ratio: 0.68 (1); 2 sources (2): [0.61 , 0.68]
	Resting membrane potential (V_rest): -62 mV (1); 1 source
	Action potential width (AP_width): [0.7, 0.8] ms (2); 1 source
	Max firing rate (Max F.R.): 67±46.8 Hz (27); 2 sources (28): [62 , 67]
	Input resistance (R_in): 1712±591.5 MΩ (30); 1 source

Notes

CA1 (e)3000 Cajal-Retzius (C-R) neurons [4094]

                                        Related types:
                                

                                        DG/CA3/CA2/Sub Cajal-Retzius neurons (v2.0 on-hold)
                                

                                        CA1 (e)3000p Local-Projecting Cajal-Retzius (v2.0 active)
                                

Notes:

N > 1.

glutamatergic

I think the solid reconstructions in Fig. 2 on p. 10 of the packet rescue this neuronal type where the other C-R types fall short. - DWW 02/10/2015

                                        - I think we should add a note about these animals being quite young (P0-P14 in Anstoltz; Quattrocolo's are older, but no axons)
                                        
                                        - Some neurites may cross into other subregions - CLR 02/11/2015

                                        CW 02/11/2015
                                

                                        CLR 02/15/2015
                                

                                        - note: EC projection?
                                        
                                        - NG-CR synapses for Keivan
                                        
                                        - "but no axons" -> Why not? both Q&M '13 & '14 papers have axons!
                                        
                                        - OK - GAA 03/12/2015

Supplement notes:

DWW 05/23/2023

I concur with the 3000 AD pattern. - JDK 05/23/2023

                                        approved. - GAA 05/24/2023
                                

Firing Pattern

Images

Parameters		View page
	TSTUT.SLN	[Evidence] [Firing Pattern]

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources

Excitatory or Inhibitory

	CA1 Neurogliaform
	CA1 O-LM

Potential sources

Excitatory or Inhibitory

	DG Local-Projecting Cajal-Retzius*
	CA1 Cajal-Retzius
	CA1 Local-Projecting Cajal-Retzius*
	CA1 Back-Projection
	CA1 LMR
	CA1 LMR-LM*
	CA1 LMR Projecting
	CA1 Neurogliaform Projecting
	CA1 Recurrent O-LM
	CA1 O-LMR
	CA1 Recurrent O-LMR*
	CA1 Oriens-QuadA Projecting
	CA1 OR-LM
	CA1 Perforant Path-Associated
	CA1 R-Receiving Apical-Targeting
	Sub CA1-Projecting Pyramidal
	EC LIII Small Pyramidal
	EC LIII Pyramidal

Potential sources known to be avoided

Excitatory or Inhibitory

	CA1 Perforant Path-Associated QuadD
	CA1 Quadrilaminar

Targets of Output

Known targets

Excitatory or Inhibitory

	CA1 Pyramidal
	CA1 Neurogliaform
	CA1 Neurogliaform Projecting

Potential targets

Excitatory or Inhibitory

	CA1 Deep Pyramidal
	CA1 Superficial Pyramidal
	CA1 Cajal-Retzius
	CA1 Local-Projecting Cajal-Retzius*
	CA1 Radiatum Giant
	CA1 Axo-axonic
	CA1 Basket
	CA1 Vertical Basket*
	CA1 Basket CCK+
	CA1 Interneuron Specific LM-R
	CA1 Interneuron Specific LMO-O
	CA1 LMR
	CA1 LMR-LM*
	CA1 Interneuron Specific LMR-O*
	CA1 LMR-R*
	CA1 Interneuron Specific LMR-R
	CA1 LMR Projecting
	CA1 Interneuron Specific O-Targeting QuadD
	CA1 Oriens/Alveus
	CA1 Perforant Path-Associated
	CA1 Perforant Path-Associated QuadD
	CA1 QuadD-RP*
	CA1 Quadrilaminar
	CA1 Schaffer Collateral-Associated
	CA1 Radial Trilaminar

Potential targets known to be avoided

Excitatory or Inhibitory

none known

Oscillation Phase Locking