CA1 Bistratified
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)0333 Bistratified S131504:Collateral-related:RO-targeting:CA1

Name derivation
This is a canonical Klausberger and Somogyi name and is the main one in the cited literature. CA1 distinguishes these cells from bistratified cells in other subregions.

Synonym(s)
CA1 bistratified cell
CA1 bistratified interneuron
CA1 BSC
CA1 wide-arbour PV-IR basket cell

List of articles
Click here to view the list
Amaral D  (2007) The Hippocampus Book
Hippocampal Neuroanatomy
Amaral D, Lavenex P.
The Hippocampus Book, 2007, Pages: 35 - 112
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Buhl EH  (1994) Nature
Diverse sources of hippocampal unitary inhibitory postsynaptic potentials and the number of synaptic release sites.
Buhl EH, Halasy K, Somogyi P.
Nature, 1994 Apr 28, 368 (6474), Pages: 823 - 828
PMID: 8159242; DOI: 10.1038/368823a0
Tags: morphology, connectivity, synapse probabilities
Daw MI  (2009) J Neurosci
Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent.
Daw MI, Tricoire L, Erdelyi F, Szabo G, McBain CJ.
J Neurosci, 2009 Sep 9, 29 (36), Pages: 11112 - 11122
PMID: 19741117; DOI: 10.1523/JNEUROSCI.5760-08.2009
Tags: connectivity, synapse probabilities
Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities
Hajos N  (1997) J Neurosci
Synaptic communication among hippocampal interneurons: properties of spontaneous IPSCs in morphologically identified cells.
Hajos N, Mody I.
J Neurosci, 1997 Nov 1, 17 (21), Pages: 8427 - 8442
PMID: 9334415
Tags: morphology, connectivity, synapse probabilities
Katona L  (2014) Neuron
Sleep and movement differentiates actions of two types of somatostatin-expressing GABAergic interneuron in rat hippocampus.
Katona L, Lapray D, Viney TJ, Oulhaj A, Borhegyi Z, Micklem BR, Klausberger T, Somogyi P..
Neuron, 2014, Pages: 872 - 886
PMID: 24794095
Tags: phases
Klausberger T  (2004) Nat Neurosci
Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo.
Klausberger T, Marton LF, Baude A, Roberts JD, Magill PJ, Somogyi P.
Nat Neurosci, 2004 Jan, 7 (1), Pages: 41 - 47
PMID: 14634650; DOI: 10.1038/nn1159
Tags: morphology, marker, phases, synapse probabilities
Klausberger T  (2008) Science
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations.
Klausberger T, Somogyi P.
Science, 2008 Jul 4, 321 (5885), Pages: 53 - 57
PMID: 18599766; DOI: 10.1126/science.1149381
Tags: morphology, marker, connectivity, synapse probabilities
Klausberger T  (2009) Eur J Neurosci
GABAergic interneurons targeting dendrites of pyramidal cells in the CA1 area of the hippocampus.
Klausberger T.
Eur J Neurosci, 2009 Sep, 30 (6), Pages: 947 - 957
PMID: 19735288; DOI: 10.1111/j.1460-9568.2009.06913.x
Tags: morphology, marker, connectivity, synapse probabilities
Lopez-Pigozzi D  (2016) eNeuro
Altered Oscillatory Dynamics of CA1 Parvalbumin Basket Cells During Theta-Gamma Rhythmopathies of Temporal Lobe Epilepsy
Lopez-Pigozzi D, Laurent F, Brotons-Mas JR, Valderrama M, Valero M, Fernandez-Lamo I, Cid E, Gomez-Dominguez D, Gal B, Lde la Prida LM.
eNeuro, 2016, Pages: 0 - 0
PMID: 27896315
Tags: phases
Pawelzik H  (2002) J Comp Neurol
Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus.
Pawelzik H, Hughes DI, Thomson AM.
J Comp Neurol, 2002 Feb 18, 443 (4), Pages: 346 - 367
PMID: 11807843; DOI: 10.1002/cne.10118
Tags: morphology, marker, membrane biophysics, connectivity, firing patterns, synapse probabilities
Sik A  (1995) J Neurosci
Hippocampal CA1 interneurons: an in vivo intracellular labeling study.
Sik A, Penttonen M, Ylinen A, Buzsaki G.
J Neurosci, 1995 Oct, 15 (10), Pages: 6651 - 6665
PMID: 7472426
Tags: morphology, connectivity, synapse probabilities
Somogyi P  (2005) J Physiol
Defined types of cortical interneurone structure space and spike timing in the hippocampus.
Somogyi P, Klausberger T.
J Physiol, 2005 Jan 1, 562 (Pt 1), Pages: 9 - 26
PMID: 15539390; DOI: 10.1113/jphysiol.2004.078915
Tags: morphology, marker, connectivity, synapse probabilities
Somogyi P  (2010) Handbook of Brain Microcircuits
Chapter: Hippocampus: Intrinsic organisation
Somogyi P.
Handbook of Brain Microcircuits, 2010, Pages: 148 - 164
ISBN: 9780195389883
Tags: morphology, connectivity, synapse probabilities
Tukker JJ  (2007) Journal of Neuroscience
Cell Type-Specific Tuning of Hippocampal Interneuron Firing During Gamma Oscillations in Vivo
Tukker JJ, Fuentealba P, Hartwich K, Somogyi P, Klausberger T.
Journal of Neuroscience, 2007, Pages: 8184 - 8189
PMID: 17670965
Tags: phases
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, marker, connectivity, synapse probabilities

Supplemental PMIDs
Click here to view the list of PMIDs

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings

Morphology
Soma
CA1:SR
CA1:SP
CA1:SO
Axons
CA1:SR
CA1:SP
CA1:SO
Dendrites
CA1:SR
CA1:SP
CA1:SO

Representative figure
Defined types of cortical interneurone structure space and spike timing in the hippocampus.
Somogyi P, Klausberger T
J Physiol, 2005 Jan 1, 562 (Pt 1), pages: 9 - 26
PMID: 15539390; DOI: 10.1113/jphysiol.2004.078915


"Figure 3. In vivo firing patterns and visualization of a [CA1] bistratified cell {CA1 Bistratified} (T83a) A, reconstruction of the neurobiotin-labelled bistratified cell. The soma and dendrites (orange) are shown complete; the axon (yellow) is shown only from 3 sections of 65 [micro]m thickness for clarity. Note that the axon branches preferentially in stratum radiatum (str. rad.) and stratum oriens (str. or.), but avoids stratum pyramidale (str. pyr.) and stratum lacunosum-moleculare. Reconstruction made by and presented courtesy of Peter Szucs."


Molecular markers
Positive
5HT-3
AR-beta1 (multiple confirming inferences)
CoupTF II
Cx36
Gaba-a-alpha (confirmed by inference)
NPY
PV
SOM
Negative
AR-beta2 (multiple confirming inferences)
CB (confirmed by inference)
CB1 (confirmed by inference)
CR (confirmed by inference)
ENK (confirmed by inference)
ErbB4 (multiple confirming inferences)
GABAa\alpha 6 (inference)
mGluR1a
MOR (multiple confirming inferences)
Mus2R
nNOS
vGluT3 (confirmed by inference)
VIP (confirmed by inference)
Mixed expression
CCK (unresolved)

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): -64 mV (1); 2 sources (2): [-65 , -64]
Threshold potential (Vthresh): 17 mV (1); 2 sources (2): [17 , 27]
Fast afterhyperpolaziring potential amplitude (Fast AHP): 13 mV (1); 2 sources (2): [12 , 13]
Action potential amplitude (APampl): 53 mV (1); 2 sources (2): [50 , 53]
Slow afterhyperpolarizing potential amplitude (Slow AHP): 3 mV (1); 2 sources (2): [2.5 , 3]

Notes
supplement to CA1 (i)0333 Bistratified added - 11/29/2015

Firing Pattern
Images
Image MissingImage MissingImage MissingImage Missing
Parameters View page
ASP. [Evidence] [Firing Pattern]
PSTUT [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=3.94;a= 0.002;b= 16.58;d= 19;C= 107;Vr= -64.67;Vt= -58.74;Vpeak= -9.93;Vmin= -59.7; Simulate
subtype: 2 k=3.06;a= 0.026;b= 7.36;d= 4;C= 208;Vr= -64.94;Vt= -44.58;Vpeak= -0.42;Vmin= -51.09; Simulate
Images
Image MissingImage Missing
ModelDB Model
Model Accession Number PubMed ID
246546 30713030
182843 24155715
123815 19489002
206378 26594151
187604 28009257

Sources of Input
Known sources
Excitatory or Inhibitory
CA1 Pyramidal
CA1 Basket
CA1 Interneuron Specific O-Targeting QuadD

Potential sources
Excitatory or Inhibitory
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Trilaminar
CA2 Pyramidal
CA2 Wide-Arbor Basket
CA2 Bistratified
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Radiatum Giant
CA1 Back-Projection
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Recurrent O-LM
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 O-RPO*
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar
Sub CA1-Projecting Pyramidal
EC LIII Small Pyramidal
EC LIII Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
CA1 Axo-axonic
CA1 Horizontal Axo-axonic

Targets of Output
Known targets
Excitatory or Inhibitory
CA1 Pyramidal
CA1 Basket
CA1 Basket CCK+

Potential targets
Excitatory or Inhibitory
CA2 Wide-Arbor Basket
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Horizontal Axo-axonic
CA1 Back-Projection
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 RO-receiving CA3-targeting*
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 O-LM
CA1 Recurrent O-LM
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 OR-LM
CA1 O-RPO*
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value
Theta (deg):186.20
Theta range:[150.60, 202.10]
Theta measurements:5
Theta representative selection:   rats, adult, male,
juxtacellular, freely moving
SWR ratio:4.06
SWR ratio range:[2.02, 6.19]
SWR ratio measurements:5
SWR ratio representative selection:   rats, adult, male,
juxtacellular, freely moving
In vivo firing rate (Hz):23.60
Firing rate range:[18.70, 56.70]
Firing rate measurements:5
Firing rate representative selection:   rats, adult, male,
juxtacellular, freely moving
Other:ripple and 3 others
Other representative selection:   rats, adult, unknown sex,
juxtacellular, urethane plus supplemental doses of ketamine and xylazine