CA1 Basket CCK+
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)2232 Basket CCK+ S110804:Perisomatic-targeting:Basket CCK+:CA1

Name derivation
These cells are known to be CCK+. CA1 distinguishes these cells from basket CCK+ cells in other subregions. "CCK+" was selected as being more compact than "CCK-positive" or "cholecystokinin-positive."

Synonym(s)
CA1 basket CCK/VGLUT3
CA1 basket CCK/VIP
CA1 basket cell
CA1 CCK-BC
CA1 CCK-expressing basket cell
CA1 CCK-IR basket cell

List of articles
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Amaral D  (2007) The Hippocampus Book
Hippocampal Neuroanatomy
Amaral D, Lavenex P.
The Hippocampus Book, 2007, Pages: 35 - 112
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Cope DW  (2002) Neuroscience
Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones target different domains of pyramidal cells in the CA1 area of the rat hippocampus.
Cope DW, Maccaferri G, Marton LF, Roberts JD, Cobden PM, Somogyi P.
Neuroscience, 2002, 109 (1), Pages: 63 - 80
PMID: 11784700; DOI: 10.1016/S0306-4522(01)00440-7
Tags: morphology, marker, membrane biophysics, firing patterns
Daw MI  (2009) J Neurosci
Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent.
Daw MI, Tricoire L, Erdelyi F, Szabo G, McBain CJ.
J Neurosci, 2009 Sep 9, 29 (36), Pages: 11112 - 11122
PMID: 19741117; DOI: 10.1523/JNEUROSCI.5760-08.2009
Tags: connectivity, synapse probabilities
Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities
Fuentealba P  (2010) J Neurosci
Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus.
Fuentealba P, Klausberger T, Karayannis T, Suen WY, Huck J, Tomioka R, Rockland K, Capogna M, Studer M, Morales M, Somogyi P.
J Neurosci, 2010 Feb 3, 30 (5), Pages: 1595 - 1609
PMID: 20130170; DOI: 10.1523/JNEUROSCI.4199-09.2010
Tags: connectivity, phases, synapse probabilities
Klausberger T  (2008) Science
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations.
Klausberger T, Somogyi P.
Science, 2008 Jul 4, 321 (5885), Pages: 53 - 57
PMID: 18599766; DOI: 10.1126/science.1149381
Tags: morphology, connectivity, synapse probabilities
Lopez-Pigozzi D  (2016) eNeuro
Altered Oscillatory Dynamics of CA1 Parvalbumin Basket Cells During Theta-Gamma Rhythmopathies of Temporal Lobe Epilepsy
Lopez-Pigozzi D, Laurent F, Brotons-Mas JR, Valderrama M, Valero M, Fernandez-Lamo I, Cid E, Gomez-Dominguez D, Gal B, Lde la Prida LM.
eNeuro, 2016, Pages: 0 - 0
PMID: 27896315
Tags: phases
Pawelzik H  (2002) J Comp Neurol
Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus.
Pawelzik H, Hughes DI, Thomson AM.
J Comp Neurol, 2002 Feb 18, 443 (4), Pages: 346 - 367
PMID: 11807843; DOI: 10.1002/cne.10118
Tags: morphology, marker, membrane biophysics, connectivity, synapse probabilities
Somogyi P  (2005) J Physiol
Defined types of cortical interneurone structure space and spike timing in the hippocampus.
Somogyi P, Klausberger T.
J Physiol, 2005 Jan 1, 562 (Pt 1), Pages: 9 - 26
PMID: 15539390; DOI: 10.1113/jphysiol.2004.078915
Tags: morphology, marker, connectivity, synapse probabilities
Somogyi P  (2010) Handbook of Brain Microcircuits
Chapter: Hippocampus: Intrinsic organisation
Somogyi P.
Handbook of Brain Microcircuits, 2010, Pages: 148 - 164
ISBN: 9780195389883
Tags: morphology, marker, connectivity, synapse probabilities
Tukker JJ  (2007) Journal of Neuroscience
Cell Type-Specific Tuning of Hippocampal Interneuron Firing During Gamma Oscillations in Vivo
Tukker JJ, Fuentealba P, Hartwich K, Somogyi P, Klausberger T.
Journal of Neuroscience, 2007, Pages: 8184 - 8189
PMID: 17670965
Tags: phases
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, marker, connectivity, synapse probabilities

Supplemental PMIDs
Click here to view the list of PMIDs

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Bacci
    • A090622 (fits the general description of "CA1 Basket CCK+" or "CA1 Trilayer Basket CCK+" based on the distribution of axons and dendrites)
    • D090910
    • F091130
  • Gulyas
  • McBain
    • 2010-01-21-2 (fits the general description of "CA1 Basket CCK+" based on the distribution of axons and dendrites)
  • McQuiston
    • cell76 (fits the general description of "CA1 Basket CCK+" based on the distribution of axons and dendrites and marker expression)
  • Scanziani
    • 3117000 (fits the general description of "CA1 Basket CCK+" or "CA1 Trilayer Basket CCK+" or "CA1 Horizontal Basket CCK+" based on the distribution of axons)
    • 31214000 (Fig S1a_031214000)
    • 3919002 (fits the general description of "CA1 Basket CCK+" or "CA1 Trilayer Basket CCK+" or "CA1 Horizontal Basket CCK+" based on the distribution of axons)
    • more ...

    • Morphology
    Soma
    CA1:SLM
    CA1:SR
    CA1:SP
    CA1:SO
    Axons
    CA1:SP
    Dendrites
    CA1:SLM
    CA1:SR
    CA1:SP
    CA1:SO

    Molecular markers
    Positive
    CB1 (confirmed by inference)
    CCK (confirmed by inference)
    Sub P Rec
    Negative
    CB
    CR (confirmed by inference)
    ENK (inference)
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (inference)
    MOR (confirmed by inference)
    PV (confirmed by inference)
    Mixed expression
    vGluT3 (subtypes)
    VIP (subtypes)

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Threshold potential (Vthresh): 22.5 mV (1); 3 sources (3): [21.9 , 29]
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 15.17±3.4 mV (5); 3 sources (7): [9 , 15.17]
    Action potential amplitude (APampl): 76.92±11.7 mV (5); 3 sources (7): [55 , 76.92]
    Max firing rate (Max F.R.): >160 Hz (1); 2 sources (2): [28 , 160]
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 6.6 mV (1); 2 sources (2): [4.8 , 6.6]
    Sag ratio: 0.78 (1); 2 sources (2): [0.78 , 0.86]
    Resting membrane potential (Vrest): -61.4±3.2 mV (5); 1 source
    Input resistance (Rin): 281.68±79.7 MΩ (5); 1 source
    Time constant (τm): 25.07±5.6 ms (5); 1 source
    Action potential width (APwidth): 0.84±0.1 ms (5); 1 source

    Notes
    perisomatic axonal targeting interpreted as PCL

    extended interpretation of SP in apical and basal directions

    supplement to CA1 (i)2232 Basket CCK+ cells added - 11/29/2015

    The cells from Cope 2002 are CCK+ and are sparsely spiny to aspiny.


    Firing Pattern
    Images
    Image Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]
    RASP.ASP. [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=1.06;a= 0.023;b= -26.87;d= 294;C= 59;Vr= -63.18;Vt= -38.18;Vpeak= 27.44;Vmin= -53.32; Simulate
    subtype: 2 k=2.48;a= 0.016;b= -12.2;d= 460;C= 477;Vr= -63.1;Vt= -51.93;Vpeak= 27.12;Vmin= -56.15; Simulate
    Images
    Image MissingImage Missing
    ModelDB Model
    Model Accession Number PubMed ID
    246546 30713030
    187604 28009257

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    CA3 Pyramidal
    CA1 Pyramidal
    CA1 Basket
    CA1 Basket CCK+
    CA1 Bistratified
    CA1 Interneuron Specific LMR-R

    Potential sources
    Excitatory or Inhibitory
    DG Local-Projecting Cajal-Retzius*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Wide-Arbor Basket
    CA2 Bistratified
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Cajal-Retzius
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Radiatum Giant
    CA1 Back-Projection
    CA1 Horizontal Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LM-R
    CA1 Interneuron Specific LMO-O
    CA1 LMR
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 LMR Projecting
    CA1 Neurogliaform
    CA1 Neurogliaform Projecting
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar
    Sub CA1-Projecting Pyramidal
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    CA1 Pyramidal
    CA1 Basket
    CA1 Basket CCK+

    Potential targets
    Excitatory or Inhibitory
    CA2 Wide-Arbor Basket
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Axo-axonic
    CA1 Back-Projection
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 Ivy
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 RP-RPO*
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value
    Theta (deg):18.00
    Theta range:[18.00, 18.00]
    Theta measurements:1
    Theta representative selection:   rats, adult, unknown sex,
    juxtacellular, urethane plus supplemental doses of ketamine and xylazine
    SWR ratio:1.64
    SWR ratio range:[1.64, 2.47]
    SWR ratio measurements:2
    SWR ratio representative selection:   rats, adult, male,
    tetrode, freely moving
    In vivo firing rate (Hz):15.30
    Firing rate range:[15.30, 35.18]
    Firing rate measurements:2
    Firing rate representative selection:   rats, adult, male,
    tetrode, freely moving
    Other:gamma and 2 others
    Other representative selection:   rats, adult, male,
    juxtacellular, urethane plus supplemental doses of ketamine and xylazine