CA1 R-Receiving Apical-Targeting
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)1300 R-Receiving Apical-Targeting S101304:Ivy/Neurogliaform Family:Ivy/Neurogliaform:CA1

Name derivation
The name describes the dendrites in SR and the axons that project to SLM and SR. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 ivy / neurogliaform cell
CA1 SCA cell
CA1 Schaffer collateral associated cell

List of articles
Click here to view the list
Tricoire L  (2011) J Neurosci
A blueprint for the spatiotemporal origins of mouse hippocampal interneuron diversity.
Tricoire L, Pelkey KA, Erkkila BE, Jeffries BW, Yuan X, McBain CJ.
J Neurosci, 2011 Jul 27, 31 (30), Pages: 10948 - 10970
PMID: 21795545; DOI: 10.1523/JNEUROSCI.0323-11.2011
Tags: morphology, marker, membrane biophysics, firing patterns, synapse probabilities

Supplemental PMIDs
Click here to view the list of PMIDs

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings

Morphology
Soma
CA1:SR
Axons
CA1:SLM
CA1:SR
Dendrites
CA1:SR

Representative figure
Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells.
Craig MT, McBain CJ
J Neurosci, 2015 Feb 25, 35 (8), pages: 3616 - 24
PMID: 25716860; DOI: 10.1523/JNEUROSCI.4166-14.2015


"Figure2. Neurolucida reconstruction of MGE basket cells in CA3 (A), CA1 { !! cell ID 4161 not found !! } (B), and CA1 pyramidal cell (C), with example whole-cell current-clamp recording and local field potential with corresponding wavelet transform in D, F, and H, respectively."


Molecular markers
Positive
CCK
PV
Negative
Chrna2 (inference)
CR (confirmed by inference)
GABAa\alpha 6 (inference)
mGluR1a (inference)
MOR (multiple confirming inferences)
SOM (confirmed by inference)
vGluT3 (confirmed by inference)
VIP (confirmed by inference)
Mixed expression
5HT-3 (subtypes)
AR-beta1 (unresolved inferential conflict)
CB1 (unresolved inferential conflict)
CoupTF II (subtypes)
ENK (subtypes)
Gaba-a-alpha (unresolved inferential conflict)
nNOS (subtypes)
NPY (subtypes)

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): -57±5 mV (15); 1 source
Input resistance (Rin): 116±63 MΩ (15); 1 source
Time constant (τm): 13±8 ms (15); 1 source
Threshold potential (Vthresh): 25 mV (1); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 25±4 mV (15); 1 source
Action potential amplitude (APampl): 48±8 mV (15); 1 source
Action potential width (APwidth): 0.54±0.11 ms (15); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 3.3 mV (1); 1 source
Sag ratio: 0.84±0.06 (15); 1 source

Notes
Rejected for merger with CA1 (-)0300 SCA-SR-CB due to strength of A:SLM. Related classes: CA1 (-)3000p-DG 3000 neurogliaform (NGF) neurons (active) CA1 (-)2311 Schaffer collateral-associated-apical dendrite-innervating (SCA-ADI) neurons (active) CA1 (-)2300 Schaffer collateral-associated (SCA) neurons (suspended) N = 2.

Firing Pattern
Images
Image MissingImage Missing
Parameters View page
ASP. [Evidence] [Firing Pattern]
NASP [Evidence] [Firing Pattern]
RASP. [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.67;a= 0.027;b= -9.29;d= 142;C= 92;Vr= -57.28;Vt= -43.19;Vpeak= -6.34;Vmin= -46.58; Simulate
subtype: 2 k=1.36;a= 0.001;b= -23.73;d= 31;C= 376;Vr= -57.51;Vt= -39.13;Vpeak= -7.29;Vmin= -47.5; Simulate
Images
Image MissingImage Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Trilaminar
CA2 Pyramidal
CA2 Bistratified
CA1 Back-Projection
CA1 Bistratified
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 LMR
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 O-RPO*
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 Trilaminar
CA1 Radial Trilaminar
Sub CA1-Projecting Pyramidal
EC LIII Small Pyramidal
EC LIII Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
CA1 Pyramidal

Potential targets
Excitatory or Inhibitory
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Cajal-Retzius
CA1 Local-Projecting Cajal-Retzius*
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 RO-receiving CA3-targeting*
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Neurogliaform
CA1 Neurogliaform Projecting
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 OR-LM
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value