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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) CA1 (i)2300 Interneuron Specific LMR-R S091204:Interneuron Specific:IS:CA1 Name derivation This cell is verified to preferentially target non-principal cells. Although more politically loaded, the phrase "interneuron specific" is more compact than "non-principal cell-specific" and is more commonly found in the cited literature. The modifier is a variant of "O-LM" because the dendrites are in SLM and SR and the axons project to SR. CA1 clarifies the subregion of origin, since the name is otherwise generic. Synonym(s) CA1 calretinin-immunoreactive interneuron CA1 CR-containing inhibitory interneuron CA1 CR-IR cell CA1 CR-IR interneuron CA1 CR-IR neuron CA1 vasoactive intestinal peptide-immunoreactive interneuron CA1 VIP-containing cell CA1 VIP-containing interneuron CA1 VIP-immunoreactive CN CA1 VIP-immunoreactive interneuron List of articles Click here to view the list Acsady L  (1996) Neuroscience Correlated morphological and neurochemical features identify different subsets of vasoactive intestinal polypeptide-immunoreactive interneurons in rat hippocampus. Acsady L, Arabadzisz D, Freund TF. Neuroscience, 1996 Jul, 73 (2), Pages: 299 - 315 PMID: 8783251; DOI: 10.1016/0306-4522(95)00610-9 Tags: morphology, marker, connectivity, synapse probabilities Gulyas AI  (1996) J Neurosci Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus. Gulyas AI, Hajos N, Freund TF. J Neurosci, 1996 May 15, 16 (10), Pages: 3397 - 3411 PMID: 8627375 Tags: morphology, marker, connectivity, synapse probabilities

Morphology

Soma
	CA1:SR
	CA1:SP

Axons
	CA1:SR

Dendrites
	CA1:SLM
	CA1:SR

Molecular markers

Positive
	VIP

Negative
	CB (confirmed by inference)
	CB1 (multiple confirming inferences)
	CCK (confirmed by inference)
	GABAa\alpha 6 (inference)
	Gaba-a-alpha (multiple confirming inferences)
	PV (confirmed by inference)
	vGluT3 (multiple confirming inferences)

Mixed expression
	CR (subtypes)

Electrophysiological properties

None known

Notes

This cell type is a result of a merger between CA1 2300 IS-1 and 2310 IS-1 Unable to merge with CA1 SCA 2300 because of target specificiy. This merger is a combination of two n=1 classes. In this merger case, contrary to the usual hippocampome rule, axons in SP are NOT counted because somatic targeting in the principal layer is less relevant for IS interneurons (GAA).

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory CA1 Interneuron Specific O-R

Potential sources Excitatory or Inhibitory DG Local-Projecting Cajal-Retzius* CA3 Pyramidal CA3c Pyramidal CA3c Umbrella Pyramidal* CA3 Trilaminar CA2 Pyramidal CA2 Bistratified CA1 Cajal-Retzius CA1 Local-Projecting Cajal-Retzius* CA1 Back-Projection CA1 Bistratified CA1 Hippocampo-subicular Projecting ENK+ CA1 Ivy CA1 Interneuron Specific LM-R CA1 LMR CA1 LMR-LM* CA1 LMR-R* CA1 Interneuron Specific LMR-R CA1 LMR Projecting CA1 Neurogliaform CA1 Neurogliaform Projecting CA1 O-LM CA1 Recurrent O-LM CA1 O-LMR CA1 Recurrent O-LMR* CA1 O-RP* CA1 Oriens-Bistratified CA1 Oriens-QuadA Projecting CA1 OR-LM CA1 O-RPO* CA1 Perforant Path-Associated CA1 Perforant Path-Associated QuadD CA1 QuadD-RP* CA1 Quadrilaminar CA1 R-Receiving Apical-Targeting CA1 R-RO* CA1 R-RP* CA1 Radiatum CA1 Interneuron Specific RO-R* CA1 RO-RP* CA1 RP-RPO* CA1 Schaffer Collateral-Associated CA1 Schaffer Collateral-Correlated* CA1 Schaffer Collateral-Receiving R-Targeting CA1 Trilaminar CA1 Radial Trilaminar Sub CA1-Projecting Pyramidal EC LIII Small Pyramidal EC LIII Pyramidal

Potential sources known to be avoided Excitatory or Inhibitory CA1 Axo-axonic CA1 Horizontal Axo-axonic

Targets of Output

Known targets Excitatory or Inhibitory CA1 Basket CCK+

Potential targets Excitatory or Inhibitory CA1 Axo-axonic CA1 Basket CA1 R-P Basket* CA1 Trilayer Basket* CA1 Vertical Basket* CA1 Trilayer Basket CCK+* CA1 Bistratified CA1 RO-receiving CA3-targeting* CA1 Hippocampo-subicular Projecting ENK+ CA1 Ivy CA1 LMR CA1 LMR-LM* CA1 Interneuron Specific LMR-O* CA1 LMR-R* CA1 Interneuron Specific LMR-R CA1 LMR Projecting CA1 Interneuron Specific O-Targeting QuadD CA1 Oriens/Alveus CA1 OR-LM CA1 Perforant Path-Associated CA1 Perforant Path-Associated QuadD CA1 QuadD-RP* CA1 Quadrilaminar CA1 Interneuron Specific R-O CA1 R-Receiving Apical-Targeting CA1 R-RO* CA1 R-RP* CA1 Radiatum CA1 Interneuron Specific RO-O CA1 Interneuron Specific RO-R* CA1 RO-RP* CA1 RP-RPO* CA1 Schaffer Collateral-Associated CA1 Schaffer Collateral-Correlated* CA1 Schaffer Collateral-Receiving R-Targeting CA1 Radial Trilaminar

Potential targets known to be avoided Excitatory or Inhibitory CA1 Pyramidal CA1 Deep Pyramidal CA1 Superficial Pyramidal CA1 Radiatum Giant

Oscillation Phase Locking

Category

Value