CA1 SO-SO
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)0003 SO-SO S131504:Collateral-related:RO-targeting:CA1

Name derivation
This is one of the cited names from a prominent lab. CA1 distinguishes these cells from SO-SO cells in other subregions. SO-SO stands for "Stratum Oriens (dendrites) - Stratum Oriens (axons)."

Synonym(s)
CA1 CaBP-containing non-pyramidal cell
CA1 CaBP-immunoreactive non-pyramidal cell
CA1 CaBP-positive neuron
CA1 CaBP-positive non-pyramidal cell
CA1 calbindin D28k-containing non-pyramidal cell
CA1 calbindin D28k-immunoreactive non-pyramidal cell
CA1 CCK-IR SO-SO cell
CA1 O-O interneuron
CA1 SO-SO cell
CA1 stratum oriens interneuron
CA1 type II calbindin D28k (CB)-immunoreactive nonprincipal neuron
CA1 type II CB-containing interneuron
CA1 type II CB-IR cell

List of articles
Click here to view the list
Cossart R  (1998) Nat Neurosci
GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells.
Cossart R, Esclapez M, Hirsch JC, Bernard C, Ben-Ari Y.
Nat Neurosci, 1998 Oct, 1 (6), Pages: 470 - 478
PMID: 10196544; DOI: 10.1038/2185
Tags: morphology
Gulyas AI  (1996) Hippocampus
Pyramidal cell dendrites are the primary targets of calbindin D28k-immunoreactive interneurons in the hippocampus.
Gulyas AI, Freund TF.
Hippocampus, 1996, 6 (5), Pages: 525 - 534
PMID: 8953305; DOI: 10.1002/(SICI)1098-1063(1996)6:5<525::AID-HIPO5>3.0.CO;2-H
Tags: morphology, marker, connectivity, synapse probabilities
Pawelzik H  (2002) J Comp Neurol
Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus.
Pawelzik H, Hughes DI, Thomson AM.
J Comp Neurol, 2002 Feb 18, 443 (4), Pages: 346 - 367
PMID: 11807843; DOI: 10.1002/cne.10118
Tags: morphology, membrane biophysics, connectivity, firing patterns, synapse probabilities
Sloviter RS  (1989) J Comp Neurol
Calcium-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity.
Sloviter RS.
J Comp Neurol, 1989 Feb 8, 280 (2), Pages: 183 - 196
PMID: 2925892; DOI: 10.1002/cne.902800203
Tags: morphology
Toth K  (1992) Neuroscience
Calbindin D28k-containing nonpyramidal cells in the rat hippocampus: their immunoreactivity for GABA and projection to the medial septum.
Toth K, Freund TF.
Neuroscience, 1992 Aug, 49 (4), Pages: 793 - 805
PMID: 1279455; DOI: 10.1016/0306-4522(92)90357-8
Tags: morphology, marker
Tyan L  (2014) J Neurosci
Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry.
Tyan L, Chamberland S, Magnin E, Camire O, Francavilla R, David LS, Deisseroth K, Topolnik L.
J Neurosci, 2014 Mar, 34 (13), Pages: 4534 - 4547
PMID: 24671999; DOI: 10.1523/JNEUROSCI.3813-13.2014
Tags: synapse probabilities

Supplemental PMIDs
Click here to view the list of PMIDs

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Topolnik

    • Morphology
    Soma
    CA1:SO
    Axons
    CA1:SO
    Dendrites
    CA1:SO

    Representative figure
    Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus.
    Pawelzik H, Hughes DI, Thomson AM
    J Comp Neurol, 2002 Feb 18, 443 (4), pages: 346 - 367
    PMID: 11807843; DOI: 10.1002/cne.10118


    "Fig. 8. Properties of a CCK-IR [cholecystokinin immunoreactive]. . . and a [CA1] CCK-IR SO-SO cell {CA1 SO-SO} (D-G) cell with somata in the SO [stratum oriens]. . . . D: Light microscopic reconstruction of the [CA1] SO-SO cell (black: soma/dendrites; grey: axonal arbour; 1,818 boutons: SO 97.8%, alveus 2.2%)."


    Molecular markers
    Positive
    5HT-3
    CB
    CoupTF II
    NPY
    Negative
    AR-beta2 (multiple confirming inferences)
    Chrna2 (inference)
    CR
    ENK (confirmed by inference)
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (multiple confirming inferences)
    mGluR1a (inference)
    nNOS
    PV (confirmed by inference)
    SOM (confirmed by inference)
    vGluT3 (confirmed by inference)
    VIP (confirmed by inference)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -59±10 mV (19); 2 sources (20): [-78 , -59]
    Threshold potential (Vthresh): 24 mV (1); 2 sources (3): [23.6 , 24]
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 15±4 mV (19); 2 sources (21): [7.3 , 15]
    Action potential amplitude (APampl): 48±10 mV (19); 2 sources (21): [48 , 58.2]
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 4.8 mV (1); 2 sources (2): [3 , 4.8]
    Sag ratio: 0.69 (1); 2 sources (2): [0.69 , 0.89]
    Input resistance (Rin): 401±212 MΩ (19); 1 source
    Time constant (τm): 38±13 ms (19); 1 source
    Action potential width (APwidth): 1.12±0.14 ms (19); 1 source
    Max firing rate (Max F.R.): >160 Hz (1); 1 source

    Notes
    This class is a merger of: - CA1 calbindin 0003 - CA1 SO-SO 0003 Possible future subclasses based on markers (calbindin, CCK) or electrophysiology (SO-SO are FS, calbindin unknown)

    Firing Pattern
    Images
    Image MissingImage Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]
    RASP. [Evidence] [Firing Pattern]
    RASP.NASP [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=0.32;a= 0.008;b= 1.72;d= -5;C= 177;Vr= -77.24;Vt= -54.22;Vpeak= -22;Vmin= -61.09; Simulate
    subtype: 2 k=0.15;a= 0.005;b= 7.44;d= 6;C= 93;Vr= -77.33;Vt= -50.48;Vpeak= 18.08;Vmin= -60.33; Simulate
    Images
    Image MissingImage Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    CA1 Pyramidal
    CA1 Interneuron Specific O-Targeting QuadD

    Potential sources
    Excitatory or Inhibitory
    CA3 Pyramidal
    CA3c Pyramidal
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Bistratified
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Radiatum Giant
    CA1 Back-Projection
    CA1 Bistratified
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 Interneuron Specific LMR-O*
    CA1 Recurrent O-LM
    CA1 Recurrent O-LMR*
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 O-RPO*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-RO*
    CA1 Interneuron Specific RO-O
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    none known

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    CA1 Pyramidal

    Potential targets
    Excitatory or Inhibitory
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Horizontal Basket
    CA1 Trilayer Basket*
    CA1 Basket CCK+
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 RO-receiving CA3-targeting*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value