Neuron type - CA1 Interneuron Specific O-R

		* indicates new v2.0 neuron type
Name		Supertype (ID:Family:Type:Subregion)
	CA1 (i)0102 Interneuron Specific O-R	S091204:Interneuron Specific:IS:CA1

Name derivation

This cell is verified to preferentially target non-principal cells. Although more politically loaded, the phrase "interneuron specific" is more compact than "non-principal cell-specific" and is more commonly found in the cited literature. This name is a variant of "O-LM" since the soma and dendrites are in SO and the axons project to SR. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
	CA1 calretinin-immunoreactive interneuron
	CA1 CR-IR cell
	CA1 CR-IR neuron

List of articles

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Gulyas AI (1996) J Neurosci

Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus.
Gulyas AI, Hajos N, Freund TF.
J Neurosci, 1996 May 15, 16 (10), Pages: 3397 - 3411
PMID: 8627375
Tags: morphology, marker, connectivity, synapse probabilities

Hajos N (1998) Neuroscience

Distinct interneuron types express m2 muscarinic receptor immunoreactivity on their dendrites or axon terminals in the hippocampus.
Hajos N, Papp EC, Acsady L, Levey AI, Freund TF.
Neuroscience, 1998 Jan, 82 (2), Pages: 355 - 376
PMID: 9466448
Tags: morphology, synapse probabilities

Supplemental PMIDs
	Click here to view the list of PMIDs 9466448 9870941 24097043

Morphology

Soma
	CA1:SO

Axons
	CA1:SR

Dendrites
	CA1:SO

Molecular markers

Positive
	CR

Negative
	AR-beta1 (inference)
	AR-beta2 (inference)
	CB1 (multiple confirming inferences)
	CCK (multiple confirming inferences)
	Chrna2 (inference)
	GABAa\alpha 6 (inference)
	mGluR1a (inference)
	MOR (multiple confirming inferences)
	PV (multiple confirming inferences)
	SOM (multiple confirming inferences)
	vGluT3 (multiple confirming inferences)

Mixed expression
	None known

Electrophysiological properties

None known

Notes

This cell type is a merger of CA1 (-)0102 IS-I and CA1 (-)0112 IS-I

Previous merger of CA1 (-)0102 IS-I with CA1 0103 O-R (aka oriens-bistratified) was rejected due to the lack of axonal evidence in SO. Namely, even with six consecutive 80 µm sections, axons were not significantly present.

According to Gulyás, the CR interneurons in this cell type innervate mostly if not exclusively other GABAergic neurons via multiple synapses

supplement to CA1 (i)0102 Interneuron Specific O-R added - 05/25/2016

The Hajos 1998 cell is m2-IR.

The Chittajallu 2013 cell is SOM+.

Besides being m2-IR, the Hajos 1998 cell is also CB-, CCK-, VIP-, PV-, CR+/-, SOM+/-

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources

Excitatory or Inhibitory

none known

Potential sources

Excitatory or Inhibitory

	CA3 Pyramidal
	CA3c Pyramidal
	CA3 Trilaminar
	CA2 Pyramidal
	CA2 Bistratified
	CA1 Pyramidal
	CA1 Deep Pyramidal
	CA1 Superficial Pyramidal
	CA1 Radiatum Giant
	CA1 Back-Projection
	CA1 Bistratified
	CA1 Hippocampo-subicular Projecting ENK+
	CA1 Ivy
	CA1 Interneuron Specific LMO-O
	CA1 Interneuron Specific LMR-O*
	CA1 Recurrent O-LM
	CA1 Recurrent O-LMR*
	CA1 Interneuron Specific O-Targeting QuadD
	CA1 Oriens/Alveus
	CA1 Oriens-Bistratified
	CA1 Oriens-QuadA Projecting
	CA1 O-RPO*
	CA1 Quadrilaminar
	CA1 Interneuron Specific R-O
	CA1 R-RO*
	CA1 Interneuron Specific RO-O
	CA1 RP-RPO*
	CA1 Schaffer Collateral-Associated
	CA1 Schaffer Collateral-Correlated*
	CA1 SO-SO
	CA1 SO-SO Projecting*
	CA1 Trilaminar
	CA1 Radial Trilaminar
	EC LIII Small Pyramidal
	EC LIII Pyramidal

Potential sources known to be avoided

Excitatory or Inhibitory

none known

Targets of Output

Known targets

Excitatory or Inhibitory

CA1 Interneuron Specific LMR-R

Potential targets

Excitatory or Inhibitory

	CA1 Axo-axonic
	CA1 Basket
	CA1 R-P Basket*
	CA1 Trilayer Basket*
	CA1 Vertical Basket*
	CA1 Basket CCK+
	CA1 Trilayer Basket CCK+*
	CA1 Bistratified
	CA1 RO-receiving CA3-targeting*
	CA1 Hippocampo-subicular Projecting ENK+
	CA1 Ivy
	CA1 LMR
	CA1 LMR-LM*
	CA1 Interneuron Specific LMR-O*
	CA1 LMR-R*
	CA1 LMR Projecting
	CA1 Interneuron Specific O-Targeting QuadD
	CA1 Oriens/Alveus
	CA1 OR-LM
	CA1 Perforant Path-Associated
	CA1 Perforant Path-Associated QuadD
	CA1 QuadD-RP*
	CA1 Quadrilaminar
	CA1 Interneuron Specific R-O
	CA1 R-Receiving Apical-Targeting
	CA1 R-RO*
	CA1 R-RP*
	CA1 Radiatum
	CA1 Interneuron Specific RO-O
	CA1 Interneuron Specific RO-R*
	CA1 RO-RP*
	CA1 RP-RPO*
	CA1 Schaffer Collateral-Associated
	CA1 Schaffer Collateral-Correlated*
	CA1 Schaffer Collateral-Receiving R-Targeting
	CA1 Radial Trilaminar

Potential targets known to be avoided

Excitatory or Inhibitory

	CA1 Pyramidal
	CA1 Deep Pyramidal
	CA1 Superficial Pyramidal
	CA1 Radiatum Giant

Oscillation Phase Locking