CA1 Back-Projection
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)1133p-DG_0001-CA3_11101 Back-Projection S121404:O-LM Family:O-LM-like:CA1

Name derivation
This is a canonical Klausberger and Somogyi name, is one in the cited literature. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 back-projection cell
CA1 back-projection interneuron
CA1 back-projection neuron
CA1 backprojecting cell
CA1 backprojection cell
CA1 backprojection interneuron
CA1 backprojection neuron
CA1 BP cell
CA1 feedback neuron

List of articles
Click here to view the list
Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, marker, connectivity, synapse probabilities
Klausberger T  (2008) Science
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations.
Klausberger T, Somogyi P.
Science, 2008 Jul 4, 321 (5885), Pages: 53 - 57
PMID: 18599766; DOI: 10.1126/science.1149381
Tags: morphology, connectivity, synapse probabilities
Klausberger T  (2009) Eur J Neurosci
GABAergic interneurons targeting dendrites of pyramidal cells in the CA1 area of the hippocampus.
Klausberger T.
Eur J Neurosci, 2009 Sep, 30 (6), Pages: 947 - 957
PMID: 19735288; DOI: 10.1111/j.1460-9568.2009.06913.x
Tags: morphology, marker, connectivity, synapse probabilities
Sik A  (1994) Science
Inhibitory CA1-CA3-hilar region feedback in the hippocampus.
Sik A, Ylinen A, Penttonen M, Buzsaki G.
Science, 1994 Sep 16, 265 (5179), Pages: 1722 - 1724
PMID: 8085161; DOI: 10.1126/science.8085161
Tags: morphology, marker, membrane biophysics, connectivity, firing patterns, synapse probabilities
Somogyi P  (2005) J Physiol
Defined types of cortical interneurone structure space and spike timing in the hippocampus.
Somogyi P, Klausberger T.
J Physiol, 2005 Jan 1, 562 (Pt 1), Pages: 9 - 26
PMID: 15539390; DOI: 10.1113/jphysiol.2004.078915
Tags: morphology, connectivity, synapse probabilities
Somogyi P  (2010) Handbook of Brain Microcircuits
Chapter: Hippocampus: Intrinsic organisation
Somogyi P.
Handbook of Brain Microcircuits, 2010, Pages: 148 - 164
ISBN: 9780195389883
Tags: morphology, connectivity, synapse probabilities
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities


Morphology
Soma
CA1:SO
Axons
DG:H
CA3:SLM
CA3:SR
CA3:SL
CA3:SO
CA1:SLM
CA1:SR
CA1:SP
CA1:SO
Dendrites
CA1:SP
CA1:SO

Representative figure
Inhibitory CA1-CA3-hilar region feedback in the hippocampus.
Sik A, Ylinen A, Penttonen M, Buzsaki G
Science, 1994 Sep 16, 265 (5179), pages: 1722 - 1724
PMID: 8085161; DOI: 10.1126/science.8085161


"Fig. 3. Axonal and dendritic arborization of an intracellularly labeled feedback CA1 neuron {CA1 Back-Projection}, reconstructed from 52 60-[micro]m coronal sections. The cell body is in the alveus. Axon collaterals were found in three regions of the hippocampus (CA1 = 24.3% of the entire axon length; CA3 = 61.5%; and the dentate hilar region = 14.2%). The dendritic tree resembled somatostatin-immunoreactive and NADPH-diaphorase neurons (10, 20). Thick lines represent the borders of the hippocampus and cell layers. Inset: summated lengths of axon collaterals along the septotemporal axis. S, septal direction; T, temporal direction. Abbreviations are as in Fig. 1."


Molecular markers
Positive
AR-beta1 (inference)
mGluR1a (inference)
nNOS
NPY
SOM (confirmed by inference)
Negative
5HT-3 (inference)
AR-beta2 (multiple confirming inferences)
CB
CR (inference)
ENK (multiple confirming inferences)
ErbB4 (multiple confirming inferences)
GABAa\alpha 6 (inference)
MOR (multiple confirming inferences)
PV (confirmed by inference)
SATB1 (inference)
vGluT3 (inference)
VIP (inference)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Threshold potential (Vthresh): [12.0, 19.0] mV (2); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): [10.0, 17.0] mV (2); 1 source
Action potential amplitude (APampl): [55.0, 61.0] mV (2); 1 source
Sag ratio: 0.99 (1); 1 source


Firing Pattern
Images
Image Missing
Parameters View page
NASP [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.67;a= 0.004;b= 15.66;d= -30;C= 133;Vr= -60.28;Vt= -47.12;Vpeak= 0.59;Vmin= -60.14; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
CA3 Pyramidal
CA3c Pyramidal
CA3 Trilaminar
CA2 Pyramidal
CA2 Wide-Arbor Basket
CA2 Bistratified
CA1 Pyramidal
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Horizontal Axo-axonic
CA1 Back-Projection
CA1 Basket
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LMO-O
CA1 Interneuron Specific LMR-O*
CA1 Recurrent O-LM
CA1 Recurrent O-LMR*
CA1 O-RP*
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 O-RPO*
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-RO*
CA1 R-RP*
CA1 Interneuron Specific RO-O
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar
Sub CA1-Projecting Pyramidal
EC LIII Small Pyramidal
EC LIII Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
CA3 Pyramidal
CA1 Pyramidal

Potential targets
Excitatory or Inhibitory
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Mossy
DG Mossy MOLDEN
DG AIPRIM
DG Axo-axonic
DG Granulosum-targeting Axo-axonic*
DG Basket
DG Basket CCK+
DG HICAP
DG Interneuron Specific IMOT*
DG Hilus-Associated Interneuron*
DG Interneuron Specific HIMOLD*
DG HIPP
DG Recurrent HIPP*
DG HIPP-CAP*
DG Recurrent HIPP-CAP*
DG HIPROM
DG Ivy*
DG MOLAX
DG Outer Molecular Layer
DG Total Molecular Layer
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Giant
CA3 Granule
CA3 Axo-axonic
CA3 Horizontal Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Horizontal Basket CCK+*
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Bilayer Ivy*
CA3 LMR-Targeting
CA3 Lucidum*
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 O-LM
CA3 Recurrent O-LM*
CA3 Interneuron Specific Oriens
CA3 Perforant Path-Associated*
CA3 Perforant Path-Associated Projecting*
CA3 Interneuron Specific Quad
CA3 QuadD-LM
CA3 Radiatum
CA3 R-LM
CA3 SO-SO
CA3 Trilaminar
CA2 Wide-Arbor Basket
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Cajal-Retzius
CA1 Local-Projecting Cajal-Retzius*
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Horizontal Axo-axonic
CA1 Back-Projection
CA1 Basket
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 RO-receiving CA3-targeting*
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Neurogliaform
CA1 Neurogliaform Projecting
CA1 O-LM
CA1 Recurrent O-LM
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 OR-LM
CA1 O-RPO*
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value