CA1 Interneuron Specific O-Targeting QuadD
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)2223 Interneuron Specific O-Targeting QuadD S091204:Interneuron Specific:IS:CA1

Name derivation
This cell is verified to preferentially target non-principal cells. Although more politically loaded, the phrase "interneuron specific" is more compact than "non-principal cell-specific" and is more commonly found in the cited literature. The modifiers describe the axons that project to SO and the dendrites that are found in four layers. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 IN-specific-III
CA1 interneuron-specific-III
CA1 interneurone specific cell III
CA1 IS-III
CA1 type III interneuron-specific interneuron
CA1 vasoactive intestinal polypeptide-positive interneuron projecting to the stratum oriens/alveus border
CA1 VIP-containing interneuron innervating the border of strata oriens and alveus
CA1 VIP-immunoreactive interneuron projecting to the border of stratum oriens and alveus
CA1 VIP-positive interneuron projecting to the O/A border

List of articles
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Acsady L  (1996) Neuroscience
Correlated morphological and neurochemical features identify different subsets of vasoactive intestinal polypeptide-immunoreactive interneurons in rat hippocampus.
Acsady L, Arabadzisz D, Freund TF.
Neuroscience, 1996 Jul, 73 (2), Pages: 299 - 315
PMID: 8783251; DOI: 10.1016/0306-4522(95)00610-9
Tags: morphology, marker, connectivity, synapse probabilities
Acsady L  (1996) Neuroscience
Different populations of vasoactive intestinal polypeptide-immunoreactive interneurons are specialized to control pyramidal cells or interneurons in the hippocampus.
Acsady L, Gorcs TJ, Freund TF.
Neuroscience, 1996 Jul, 73 (2), Pages: 317 - 334
PMID: 8783252; DOI: 10.1016/0306-4522(95)00609-5
Tags: morphology, connectivity, synapse probabilities
Chamberland S  (2010) Front Cell Neurosci
Synapse-specific inhibitory control of hippocampal feedback inhibitory circuit.
Chamberland S, Salesse C, Topolnik D, Topolnik L.
Front Cell Neurosci, 2010, 4, Pages: 130 -
PMID: 21060720; DOI: 10.3389/fncel.2010.00130
Tags: morphology, connectivity, firing patterns, synapse probabilities
Klausberger T  (2008) Science
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations.
Klausberger T, Somogyi P.
Science, 2008 Jul 4, 321 (5885), Pages: 53 - 57
PMID: 18599766; DOI: 10.1126/science.1149381
Tags: morphology, connectivity, synapse probabilities
Somogyi P  (2005) J Physiol
Defined types of cortical interneurone structure space and spike timing in the hippocampus.
Somogyi P, Klausberger T.
J Physiol, 2005 Jan 1, 562 (Pt 1), Pages: 9 - 26
PMID: 15539390; DOI: 10.1113/jphysiol.2004.078915
Tags: morphology, marker, connectivity, synapse probabilities
Somogyi P  (2010) Handbook of Brain Microcircuits
Chapter: Hippocampus: Intrinsic organisation
Somogyi P.
Handbook of Brain Microcircuits, 2010, Pages: 148 - 164
ISBN: 9780195389883
Tags: morphology, connectivity, synapse probabilities
Tyan L  (2014) J Neurosci
Dendritic inhibition provided by interneuron-specific cells controls the firing rate and timing of the hippocampal feedback inhibitory circuitry.
Tyan L, Chamberland S, Magnin E, Camire O, Francavilla R, David LS, Deisseroth K, Topolnik L.
J Neurosci, 2014 Mar, 34 (13), Pages: 4534 - 4547
PMID: 24671999; DOI: 10.1523/JNEUROSCI.3813-13.2014
Tags: morphology, synapse probabilities
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities

Supplemental PMIDs
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List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Gulyas
  • Topolnik

    • Morphology
    Soma
    CA1:SR
    CA1:SP
    Axons
    CA1:SO
    Dendrites
    CA1:SLM
    CA1:SR
    CA1:SP
    CA1:SO

    Molecular markers
    Positive
    CR
    mGluR7a
    VIP
    Negative
    AR-beta1 (inference)
    AR-beta2 (inference)
    CB (confirmed by inference)
    CB1 (multiple confirming inferences)
    CCK (confirmed by inference)
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (multiple confirming inferences)
    MOR (multiple confirming inferences)
    PV (confirmed by inference)
    vGluT3 (multiple confirming inferences)
    Mixed expression
    None known

    Electrophysiological properties
    None known

    Notes

    CA1 (i)2203 IS3 neurons

    Notes:

    N = 3

    I think this should be merged with IS O-target QuadD (2223) - GAA

    CA1 (i) 2223 IS O-targeting QuadD (IS O-target QuadD) neurons

    Supplement Notes:

    In the interests of parsimony, I also support the aggressive merger of these cells as supplements to the 2223 cell type. - DWW 07/21/2015

    I support all of these aggressive mergers and sign off on the packets. - CLR 09/08/2015

    I am okay with the merger. - CW 09/08/2015

    AOK - GAA 11/29/2015

    CA1 (-)2223 quadrilaminar interneuron specific-3 (quad IS-3) neurons

    Notes:

    Target O-LM cells (Acsady 1996)

    Packet contains papers with chemical marker data

    supplement to CA1 (i)2223 IS O-targeting QuadD added - 11/29/2015

    CA1 (i)2223 IS O-targeting QuadD (IS O-target QuadD) neurons [4020]

    Related types: CA1 (i)2003 Interneuron Specific LMO-O (v1.0 active)

    Notes: This neuron type has dendrites in all four layers, which distinguishes it from the IS LMO-O type.

    [Y:D:SP]{low}

    FP present

    DWW 05/23/2023

    I concur with the 2223 AD pattern. - JDK 05/23/2023

    approved. - GAA 05/24/2023

    Firing Pattern
    Images
    Image Missing
    Parameters View page
    TSTUT.PSTUT [Evidence] [Firing Pattern]
    ModelDB Model
    Model Accession Number PubMed ID
    223031 27679813

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    CA1 Interneuron Specific LM-R

    Potential sources
    Excitatory or Inhibitory
    DG Local-Projecting Cajal-Retzius*
    CA3 Pyramidal
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Wide-Arbor Basket
    CA2 Bistratified
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Cajal-Retzius
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Radiatum Giant
    CA1 Back-Projection
    CA1 Basket
    CA1 Horizontal Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 LMR
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 Neurogliaform
    CA1 Neurogliaform Projecting
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar
    Sub CA1-Projecting Pyramidal
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    CA1 Bistratified
    CA1 O-LM
    CA1 O-LMR
    CA1 SO-SO

    Potential targets
    Excitatory or Inhibitory
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Horizontal Basket
    CA1 Trilayer Basket*
    CA1 Basket CCK+
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 RO-receiving CA3-targeting*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 Recurrent O-LM
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal

    Oscillation Phase Locking
    Category
    Value