CA1 LMR Projecting
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)3300p-DG_1110 LMR Projecting S101304:Ivy/Neurogliaform Family:Ivy/Neurogliaform:CA1

Name derivation
This name describes the multilayered axons and dendrites that occupy both occupy SLM and SR. There are no hyphens to avoid any confusion with "O-LM"-like names. The modifier distinguishes this type from the non-projecting CA1 LMR. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 perforant-path-associated cell
CA1 R-LM cell

List of articles
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Hajos N  (1997) J Neurosci
Synaptic communication among hippocampal interneurons: properties of spontaneous IPSCs in morphologically identified cells.
Hajos N, Mody I.
J Neurosci, 1997 Nov 1, 17 (21), Pages: 8427 - 8442
PMID: 9334415
Tags: morphology, connectivity, synapse probabilities
Klausberger T  (2005) J Neurosci
Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations.
Klausberger T, Marton LF, O'Neill J, Huck JH, Dalezios Y, Fuentealba P, Suen WY, Papp E, Kaneko T, Watanabe M, Csicsvari J, Somogyi P.
J Neurosci, 2005 Oct 19, 25 (42), Pages: 9782 - 9793
PMID: 16237182; DOI: 10.1523/JNEUROSCI.3269-05.2005
Tags: morphology, marker, connectivity, phases, synapse probabilities
Lacaille JC  (1988) J Neurosci
Stratum lacunosum-moleculare interneurons of hippocampal CA1 region. I. Intracellular response characteristics, synaptic responses, and morphology.
Lacaille JC, Schwartzkroin PA.
J Neurosci, 1988 Apr, 8 (4), Pages: 1400 - 1410
PMID: 3357023
Tags: morphology

Supplemental PMIDs
Click here to view the list of PMIDs


Morphology
Soma
CA1:SLM
CA1:SR
Axons
DG:SMo
DG:SMi
DG:SG
CA1:SLM
CA1:SR
Dendrites
CA1:SLM
CA1:SR

Representative figure
Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations.
Klausberger T, Marton LF, O'Neill J, Huck JH, Dalezios Y, Fuentealba P, Suen WY, Papp E, Kaneko T, Watanabe M, Csicsvari J, Somogyi P
J Neurosci, 2005 Oct 19, 25 (42), pages: 9782 - 9793
PMID: 16237182; DOI: 10.1523/JNEUROSCI.3269-05.2005


"Figure 3. In vivo firing patterns and visualization of a CCK[cholecystokinin]-expressing perforant-path-associated [CA1] cell {CA1 LMR Projecting} (T82e). ... B, Reconstruction of the [CA1] soma and dendrites (orange) is shown complete; the axon (yellow) is shown from selected series of sections as indicated (bottom section number marks more caudal position). Scale bar (same for all 3 projections), 100 [micro]m."


Molecular markers
Positive
CB
CB1 (confirmed by inference)
CCK (confirmed by inference)
Negative
AR-beta1 (multiple confirming inferences)
Chrna2 (inference)
CR (confirmed by inference)
ENK (multiple confirming inferences)
GABAa\alpha 6 (inference)
Gaba-a-alpha (multiple confirming inferences)
mGluR1a (confirmed by inference)
MOR (multiple confirming inferences)
NPY (multiple confirming inferences)
PV (confirmed by inference)
SOM (multiple confirming inferences)
Sub P Rec
vGluT3 (confirmed by inference)
VIP (confirmed by inference)
Mixed expression
None known

Electrophysiological properties
None known

Notes
Rejected merger with CA1 (-)3300-DG 0110 radiatum- and dentate-innervating (RADI) neurons (new) due to weakness of D:CA1:SR and A:DG:SMo. Sub-threshold evidence for dendrites in CA1:SO.

Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG Local-Projecting Cajal-Retzius*
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Trilaminar
CA2 Pyramidal
CA2 Bistratified
CA1 Cajal-Retzius
CA1 Local-Projecting Cajal-Retzius*
CA1 Back-Projection
CA1 Bistratified
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 LMR
CA1 LMR-LM*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Neurogliaform
CA1 Neurogliaform Projecting
CA1 O-LM
CA1 Recurrent O-LM
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 OR-LM
CA1 O-RPO*
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 Trilaminar
CA1 Radial Trilaminar
Sub CA1-Projecting Pyramidal
EC LIII Small Pyramidal
EC LIII Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
DG Granule
CA1 Pyramidal
CA1 Schaffer Collateral-Associated

Potential targets
Excitatory or Inhibitory
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Semilunar Granule
DG Cajal-Retzius*
DG Local-Projecting Cajal-Retzius*
DG Mossy MOLDEN
DG AIPRIM
DG Axo-axonic
DG Granulosum-targeting Axo-axonic*
DG Axo-axonic GRALDEN*
DG Basket
DG Basket GRALDEN*
DG Basket CCK+
DG Interneuron Specific COLTAR*
DG COM-MOPP*
DG HICAP
DG Interneuron Specific IMOT*
DG Interneuron Specific HIMOLD*
DG Interneuron Specific HIPRO*
DG HIPROM
DG Ivy*
DG MOCAP
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG MOPP
DG Neurogliaform
DG Wide-Arbor Neurogliaform*
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Cajal-Retzius
CA1 Local-Projecting Cajal-Retzius*
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 RO-receiving CA3-targeting*
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LM-R
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 Neurogliaform
CA1 Neurogliaform Projecting
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 OR-LM
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value
Theta (deg):300.00
Theta range:[300.00, 300.00]
Theta measurements:1
Theta representative selection:   rats, adult, unknown sex,
juxtacellular, urethane plus supplemental doses of ketamine and xylazine
SWR ratio:0.97
SWR ratio range:[0.97, 0.97]
SWR ratio measurements:1
SWR ratio representative selection:   rats, adult, unknown sex,
juxtacellular, urethane plus supplemental doses of ketamine and xylazine
In vivo firing rate (Hz):2.90
Firing rate range:[2.90, 2.90]
Firing rate measurements:1
Firing rate representative selection:   rats, adult, unknown sex,
juxtacellular, urethane plus supplemental doses of ketamine and xylazine
Other:firingRateNonBaseline
Other representative selection:   rats, adult, unknown sex,
juxtacellular, urethane plus supplemental doses of ketamine and xylazine