CA1 Quadrilaminar
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA1 (i)3333 Quadrilaminar S091204:Interneuron Specific:IS:CA1

Name derivation
This is the only name in the cited literature. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)
CA1 quadrilaminar cell
CA1 quadrilaminar interneurone

List of articles
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Pawelzik H  (2002) J Comp Neurol
Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus.
Pawelzik H, Hughes DI, Thomson AM.
J Comp Neurol, 2002 Feb 18, 443 (4), Pages: 346 - 367
PMID: 11807843; DOI: 10.1002/cne.10118
Tags: morphology, marker, membrane biophysics, connectivity, firing patterns, synapse probabilities

List of Hippocampome.org to NeuroMorpho.Org mappings
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  • Gulyas
  • McBain
    • 2009-12-28-14 (fits the general description of "CA1 Quadrilaminar" based on the distribution of axons and dendrites and marker expression)

    • Morphology
    Soma
    CA1:SLM
    CA1:SR
    Axons
    CA1:SLM
    CA1:SR
    CA1:SP
    CA1:SO
    Dendrites
    CA1:SLM
    CA1:SR
    CA1:SP
    CA1:SO

    Representative figure
    Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus.
    Pawelzik H, Hughes DI, Thomson AM
    J Comp Neurol, 2002 Feb 18, 443 (4), pages: 346 - 367
    PMID: 11807843; DOI: 10.1002/cne.10118


    "Fig. 12. Features of a regular-spiking CCK-IR [cholecystokinin immunoreactive] quadrilaminar cell {CA1 Quadrilaminar} [in CA1] (A-D). . . . A: Light microscopic reconstruction of the [CA1] quadrilaminar cell (black: soma/dendrite; grey: axonal arbour; 3,221 boutons: alveus 0.3%, SO [stratum oriens] 9.6%, SP [stratum pyramidale] 3.6%, SR [stratum radiatum] 66.4%, SLM [stratum lacunosum moleculare] 20.1%)."


    Molecular markers
    Positive
    CCK
    CR
    mGluR1a (inference)
    PV
    SOM (confirmed by inference)
    Negative
    5HT-3 (confirmed by inference)
    AR-beta1 (multiple confirming inferences)
    AR-beta2 (inference)
    CB (multiple confirming inferences)
    CoupTF II
    ENK (confirmed by inference)
    ErbB4 (multiple confirming inferences)
    GABAa\alpha 6 (inference)
    MOR (multiple confirming inferences)
    nNOS
    NPY (confirmed by inference)
    vGluT3 (confirmed by inference)
    VIP (confirmed by inference)
    Mixed expression
    CB1 (unresolved inferential conflict)
    Gaba-a-alpha (unresolved inferential conflict)

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): [-61.0, -56.0] mV (2); 1 source
    Threshold potential (Vthresh): 21.1 mV (1); 1 source
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 11.9 mV (1); 1 source
    Action potential amplitude (APampl): 57.7 mV (1); 1 source
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 6.9 mV (1); 1 source


    Firing Pattern
    Images
    Image Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=1.78;a= 0.006;b= -3.45;d= 52;C= 186;Vr= -73.48;Vt= -54.94;Vpeak= 7.07;Vmin= -64.4; Simulate
    Images
    Image Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    CA1 Pyramidal

    Potential sources
    Excitatory or Inhibitory
    DG Local-Projecting Cajal-Retzius*
    CA3 Pyramidal
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Wide-Arbor Basket
    CA2 Bistratified
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Cajal-Retzius
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Radiatum Giant
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Horizontal Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LM-R
    CA1 Interneuron Specific LMO-O
    CA1 LMR
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 Neurogliaform
    CA1 Neurogliaform Projecting
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar
    Sub CA1-Projecting Pyramidal
    EC LIII Small Pyramidal
    EC LIII Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    none known

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    CA1 Pyramidal

    Potential targets
    Excitatory or Inhibitory
    CA2 Wide-Arbor Basket
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Horizontal Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 RO-receiving CA3-targeting*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LM-R
    CA1 Interneuron Specific LMO-O
    CA1 LMR
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 Neurogliaform
    CA1 Neurogliaform Projecting
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Cajal-Retzius
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Radiatum Giant

    Oscillation Phase Locking
    Category
    Value