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* indicates new v2.0 neuron type
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Name
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Supertype (ID:Family:Type:Subregion)
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CA3 (e)22223 Athorny Pyramidal*
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S040402:Glutamatergic PC:Pyramidal:CA3
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Name derivation
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Athorny distinguishes these cells from the canonical CA3 Pyramidal cells in that they lack thorny excrescences on their dendrites. CA3 distinguishes these cells from pyramidal cells in other subregions.
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Synonym(s)
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CA3 bursting neuron
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CA3 pyramidal cell
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Click here to view the list
Hajos N (2004) J Neurosci
Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro. Hajos N, Palhalmi J, Mann EO, Nemeth B, Paulsen O, Freund TF.
J Neurosci,
2004 Oct 13, 24 (41),
Pages: 9127 - 9137
PMID: 15483131; DOI: 10.1523/JNEUROSCI.2113-04.2004
Tags: morphology, connectivity, synapse probabilities
Hunt DL (2018) Nature Neuroscience
A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus Hunt DL, Linaro D, Si B, Romani S, Spruston N.
Nature Neuroscience,
2018, 21 (7),
Pages: 985 - 995
PMID: 29915194; DOI: 10.1038/s41593-018-0172-7
Tags: morphology, marker, membrane biophysics
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List of Hippocampome.org to NeuroMorpho.Org mappings
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Click here to view the list of mappings
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A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus
Hunt DL, Linaro D, Si B, Romani S, Spruston N
Nature Neuroscience, 2018, 21 (7), pages: 985 - 995
PMID: 29915194; DOI: 10.1038/s41593-018-0172-7
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"Fig. 1 | Morphofunctional phenotypes and cytoarchitecture of CA3 principal cells. ... d, Representative morphological reconstructions for (left) the regular-spiking cell shown above in a (dendrites, black; axon, green) and (right) the bursting neuron {CA3 Athorny Pyramidal*} shown above in a (dendrites, red; axon, blue) following whole-cell recording in acute mouse hippocampal slices. Regular-spiking cells had thorny excrescences, (left and top middle), whereas intrinsically bursting cells lacked thorns (right and bottom middle)" |
| Mixed expression |
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None known |
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Electrophysiological properties
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CA3 (e)22003 Athorny Pyramidal (aPC) cells [2121]
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Related types:
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CA3 (e)23223p Pyramidal (v1.0 active)
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CA3 (e)33331p Pyramidal (v2.0 on-hold)
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CA3c (e)23223p Umbrella Pyramidal (v2.0 active)
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CA3c (e)03223p Pyramidal (v1.0 active)
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CA3c (e)02100 Displaced Horizontal Pyramidal (unapproved v2.0 on-hold)
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CA3 (e)23003 Athorny Pyramidal (v2.0 on-hold approved)
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Notes: These neurons primarily differ from the other Pyramidal neurons of CA3 in that they lack thorny excrescences. Also, from the limited reconstructions, the axon appears to be restricted primarily to SO.
bursting and athorny
FP and ephys present
distal (CA3a,b) and deep
VGAT-, VGLUT1+, VGLUT2+
receive little or no direct mossy-fiber input
After reviewing the provided packet, I concur with the interpretations and approve of this neuron type for v2.0. - JDK 10/13/2021
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I would suggest changing this to a 23003. Dendritic absence from SL (and SP) is supported by the report of little if any direct MF input; besides, all available reconstructions appear to not branch within SL/SP. This is overall consistent with 'passing-by' dendrites (to SR & SO) and our <15% rule. As for the axon in SR, I'm hesitant to remove based on explicitly incomplete slice tracings, and page 12 of the packet does show an axon in SR. Iā??m happy to discuss and be convinced otherwise if you [DWW] and JDK are hesitant. - GAA 01/26/2022
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I agree that the dendritic branches appear to disappear in the CA3:SL_SP region, in all three references. I am not so convinced by the presence of axons in CA3:SR. We normally classify based on the evidence at hand, as limited as it might be, and not on what we believe might exist had neurites not been cut. - DWW 01/28/2022
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After reviewing this packet once more, I am in agreement that there is dendritic absence from SL and SP. As far as axonal presence, I concur with DWW's comments. Happy to discuss and elaborate further as well. - JDK 01/28/2022
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But isnā??t the evidence on page 12 of the packet showing axon in SR? - GAA 01/28/2022
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Yes there is one reconstruction of the 14 provided in the packet where there certainly appears to be evidence of axonal presence in SR (on page 12 as you had mentioned). On a pertinent note, when I had reviewed CA1 O-R (Unique ID # 4168), I had noticed a reconstruction that differed in its A-D pattern from the rest in the provided packet (axons in CA1 SP so a pattern of 0112 whereas the rest did not, pattern of 0102). With a new invoked rule for compressing types that involved counting axonal presence in principal cell layers due to the issue of target specificity but discounting dendrites, we re-interpreted another reconstruction in the CA1 O-R packet as also having this 0112 pattern which in combination with the first one identified we proposed as a new neuron type.
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In the same vein, perhaps we can set aside the reconstruction with axonal presence in SR as an on-hold neuron type for when we have an additional reconstruction also having an A-D pattern of 23003? - JDK 01/28/2022
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I would be in favor of the active neuron type being 22003 for the moment, and a new on-hold neuron type being 23003. With the addition of future reconstructions, we can revisit the possibility of merging the two neuron types. - DWW 01/31/2022
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Ok, you convinced me - GAA 01/31/2022
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Images
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No image is associated with this neuron |
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Parameters
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| | No parameter associated with this neuron |
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Model Accession Number
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PubMed ID
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Potential sources known to be avoided
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Potential targets known to be avoided
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| Oscillation Phase Locking |
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