CA3 Bilayer Ivy*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (i)00330 Bilayer Ivy* S101302:Ivy/Neurogliaform Family:Ivy/Neurogliaform:CA3

Name derivation
This is the only name in the cited literature. The phrase "bilayer" describes the fact that the neurites only extend into SL and SP. CA3 distinguishes these cells from ivy cells in other subregions.

Synonym(s)
CA3 ivy cell

List of articles
Click here to view the list
Hajos N  (2013) J Neurosci
Input-output features of anatomically identified CA3 neurons during hippocampal sharp wave/ripple oscillation in vitro.
Hajos N, Karlocai MR, Nemeth B, Ulbert I, Monyer H, Szabo G, Erdelyi F, Freund TF, Gulyas AI.
J Neurosci, 2013 Jul, 33 (28), Pages: 11677 - 11691
PMID: 23843535; DOI: 10.1523/JNEUROSCI.5729-12.2013
Tags: morphology, marker, synapse probabilities


Morphology
Soma
CA3:SP
Axons
CA3:SL
CA3:SP
Dendrites
CA3:SL
CA3:SP

Representative figure
Input-output features of anatomically identified CA3 neurons during hippocampal sharp wave/ripple oscillation in vitro.
Hajos N, Karlocai MR, Nemeth B, Ulbert I, Monyer H, Szabo G, Erdelyi F, Freund TF, Gulyas AI
J Neurosci, 2013 Jul, 33 (28), pages: 11677 - 11691
PMID: 23843535; DOI: 10.1523/JNEUROSCI.5729-12.2013


"Figure5. Comparison of synaptic conductances during SWRs in spiking and nonspiking neurons. ... Only nonspiking ivy cells were observed (n = 5) ... C, A camera lucida reconstruction of an ivy cell {CA3 Bilayer Ivy*} (dendrites, black; axon, red). Scale bar, 100 [micro]m."


Molecular markers
Positive
None known
Negative
CB1 (multiple confirming inferences)
CCK (confirmed by inference)
GABAa\alpha 6 (inference)
PV
Mixed expression
None known

Electrophysiological properties
None known

Notes

CA3 (i)00330 Bilayer Ivy neurons [2052]

Related types: CA3 (i)03333 Ivy cells
CA3 (i)03330p Mossy Fiber-Associated
CA3 (i)03300 Lucidum-Radiatum
CA3 (i)02310 Lucidum LAX
CA3 (i)00300 Lucidum

Notes:

smooth dendrites

PV-, CCK-

I am not comfortable with making this interpretation without the SR/SL border. If all of the dendrites are in SL, then SL is as wide as SP. - CW 02/11/2015

Even if SL is half the width of SP, is there sufficient penetration into SR to count the neurites there? - DWW 02/12/2015

I sign off on 00330. - CLR 02/15/2015

If SL were half of SP, I think there would be enough dendrites in SR to count them. I still do not approve this one. - CW 02/18/2015

So is your interpretation 02330 or 03330? - DWW 09/10/2015

02330 with axons in SR below 15% - CW 09/16/2015

I'm sticking with 00330. In some figures I see on our portal, SL is the same approximate width as SP. Sometimes SL is show as slightly wider. If the dendrites do make it into SR, they don't make it far. - CLR 10/10/2015

I agree with 00330. - DWW 10/19/2015

Name?? Where distinct from existing Ivy and/or BC? - GAA 11/29/2015

These cells have now been semi-formally named CA3 (00330) Bilayer Ivy cells. - DWW 04/20/2016

I approve and like the name. - CLR 05/04/2016

Okay with 0330 and name - CW 05/04/2016

Ok (sigh) add related types! (Lucidum LAX?) - GAA 05/25/2016

Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG Granule
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Semilunar Granule
DG HIPROM
CA3 Giant
CA3 Granule
CA3 Basket
CA3 Basket CCK+
CA3 Horizontal Basket CCK+*
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Bilayer Ivy*
CA3 Lucidum*
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Interneuron Specific Oriens
CA3 Interneuron Specific Quad
CA3 Trilaminar
CA2 Pyramidal
CA2 Wide-Arbor Basket
CA1 Back-Projection
CA1 RO-receiving CA3-targeting*

Potential sources known to be avoided
Excitatory or Inhibitory
CA3 Axo-axonic
CA3 Horizontal Axo-axonic

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Bilayer Ivy*
CA3 LMR-Targeting
CA3 Lucidum*
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Interneuron Specific Quad
CA3 QuadD-LM
CA2 Wide-Arbor Basket

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value