Neuron type - CA3 Bistratified

		* indicates new v2.0 neuron type
Name		Supertype (ID:Family:Type:Subregion)
	CA3 (i)03333 Bistratified	S131502:Collateral-related:RO-targeting:CA3

Name derivation
	This is the most well-known name in the cited literature, which is a variant of the more well known CA1 Bistratified. CA3 distinguishes these cells from bistratified cells in other subregions.

Synonym(s)
	CA3 bistratified cell
	CA3 dendritic inhibitory cell

List of articles

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Amaral D (2007) The Hippocampus Book

Hippocampal Neuroanatomy
Amaral D, Lavenex P.
The Hippocampus Book, 2007, Pages: 35 - 112
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities

Fidzinski P (2015) Nature Communications

KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations
Fidzinski P, Korotkova T, Heidenreich M, Maier N, Schuetze S, Kobler O, Zuschratter W, Schmitz D, Ponomarenko A, Jentsch TJ.
Nature Communications, 2015, 6, Pages: 6254 -
PMID: 25649132; DOI: 10.1038/ncomms7254
Tags: morphology, firing patterns

Freund TF (1996) Hippocampus

Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities

Miles R (1996) Neuron

Differences between somatic and dendritic inhibition in the hippocampus.
Miles R, Toth K, Gulyas AI, Hajos N, Freund TF.
Neuron, 1996 Apr, 16 (4), Pages: 815 - 823
PMID: 8607999; DOI: 10.1016/S0896-6273(00)80101-4
Tags: morphology, connectivity, synapse probabilities

Szabo GG (2014) Hippocampus

Anatomically heterogeneous populations of CB1 cannabinoid receptor-expressing interneurons in the CA3 region of the hippocampus show homogeneous input-output characteristics.
Szabo GG, Papp OI, Mate Z, Szabo G, Hajos N.
Hippocampus, 2014 Dec, 24 (12), Pages: 1506 - 1523
PMID: 25044969; DOI: 10.1002/hipo.22330
Tags: connectivity, synapse probabilities

Supplemental PMIDs
	Click here to view the list of PMIDs 25044969

Morphology

Soma
	CA3:SP
	CA3:SO

Axons
	CA3:SR
	CA3:SL
	CA3:SP
	CA3:SO

Dendrites
	CA3:SR
	CA3:SL
	CA3:SP
	CA3:SO

Representative figure

Interneurons of the hippocampus.
Freund TF, Buzsaki G
Hippocampus, 1996, 6 (4), pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I

"FIGURE 12. A: A bistratified cell {CA3 Bistratified} in the CA3 region intracellularly filled with biocytin in a 400-[micro]m-thick guinea pig slice in vitro and reconstructed from serial 60-[micro]m Vibratome sections. The dendritic tree is bitufted and does not reach stratum lacunosum-moleculare. The axon spans all layers except stratum lacunosum-moleculare, but varicose collaterals are relatively sparse in strata pyramidale and lucidum. The arbor is broad in the tangential direction and limited to the proximal half of the layer in stratum radiatum. The inserts on the top show the area occupied by the axon in the slice and (on the right) that the bouton density along the axon collaterals is high in strata oriens and radiatum but low in strata pyramidale and lucidum. From unpublished work of R. Miles, N. Hajos, A.I. Gulyas, K.Toth, and T.F. Freund. B: A backprojection neuron {CA1 Back-Projection} in CA1 intracellularly recorded and filled with biocytin in vivo in the rat. The dendrites remain in stratum oriens, but the axon, in addition to its local collaterals in CA1, forms large arbors in CA3 stratum radiatum and in the hilar region of the dentate gyrus. The insert shows the septotemporal distribution of the axon. The axon length/bin is indicated on the ordinate, showing a peak near the level of the soma. Reprinted with permission from Sik A, Penttonen M, Ylinen A, Buzsaki G (1994) "Inhibitory CA1-CA3-hilar region feedback in the hippocampus." Science 265:1722-1724. American Association for the Advancement of Science. (1994)."

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	None known

Electrophysiological properties

None known

Notes

CA3 (i)03333 Bistratified cells (BiC) [2045]

                                        Related types:
                                

                                        CA3 (i)03333 Ivy (v1.0 active)
                                

                                        CA3 (i)03333p-DG_0113 mossy fiber-associated (CB1+) (v1.0 on-hold)
                                

                                        CA3 (i)03333p-DG_0003 Interneuron Specific Quad (v1.0 active)
                                

                                        CA3 (i)03333p-CA1_0110-Sub_010 double projection (v1.0 on-hold)
                                

Supplement notes: This neuron type is non-projecting, is not declared to be interneuron specific, and is not dense in its neurites, which distinguishes it from the other neuron types.

[Y:D:CA3:SP]{low}
[Y:A:CA3:SP]{low}
FP

DWW 05/23/2023

I concur with the 03333 AD pattern. - JDK 05/23/2023

                                        approved. - GAA 05/24/2023
                                

Firing Pattern

Images

Parameters		View page
	NASP	[Evidence] [Firing Pattern]

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources

Excitatory or Inhibitory

none known

Potential sources

Excitatory or Inhibitory

	DG Granule
	DG Adult-Born Immature Granule*
	DG Hilar Ectopic Granule
	DG Semilunar Granule
	DG HIPROM
	CA3 Pyramidal
	CA3 Athorny Pyramidal*
	CA3c Pyramidal
	CA3c Umbrella Pyramidal*
	CA3 Giant
	CA3 Granule
	CA3 Basket
	CA3 Basket CCK+
	CA3 Horizontal Basket CCK+*
	CA3 Mossy Fiber-Associated Basket CCK+*
	CA3 Bistratified
	CA3 Ivy
	CA3 Bilayer Ivy*
	CA3 LMR-Targeting
	CA3 Lucidum*
	CA3 Lucidum LAX
	CA3 Lucidum ORAX
	CA3 Lucidum-Radiatum
	CA3 Spiny Lucidum
	CA3 Mossy Fiber-Associated
	CA3 Mossy Fiber-Associated ORDEN
	CA3 O-LM
	CA3 Interneuron Specific Oriens
	CA3 Perforant Path-Associated Projecting*
	CA3 Interneuron Specific Quad
	CA3 Radiatum
	CA3 SO-SO
	CA3 Trilaminar
	CA2 Pyramidal
	CA2 Wide-Arbor Basket
	CA1 Back-Projection
	CA1 RO-receiving CA3-targeting*

Potential sources known to be avoided

Excitatory or Inhibitory

	CA3 Axo-axonic
	CA3 Horizontal Axo-axonic

Targets of Output

Known targets

Excitatory or Inhibitory

	CA3 Pyramidal
	CA3 Basket

Potential targets

Excitatory or Inhibitory

	CA3 Athorny Pyramidal*
	CA3c Pyramidal
	CA3c Umbrella Pyramidal*
	CA3 Giant
	CA3 Granule
	CA3 Axo-axonic
	CA3 Horizontal Axo-axonic
	CA3 Basket CCK+
	CA3 Horizontal Basket CCK+*
	CA3 Mossy Fiber-Associated Basket CCK+*
	CA3 Bistratified
	CA3 Ivy
	CA3 Bilayer Ivy*
	CA3 LMR-Targeting
	CA3 Lucidum*
	CA3 Lucidum LAX
	CA3 Lucidum ORAX
	CA3 Lucidum-Radiatum
	CA3 Spiny Lucidum
	CA3 Mossy Fiber-Associated
	CA3 Mossy Fiber-Associated ORDEN
	CA3 O-LM
	CA3 Recurrent O-LM*
	CA3 Interneuron Specific Oriens
	CA3 Perforant Path-Associated*
	CA3 Perforant Path-Associated Projecting*
	CA3 Interneuron Specific Quad
	CA3 QuadD-LM
	CA3 Radiatum
	CA3 R-LM
	CA3 SO-SO
	CA3 Trilaminar
	CA2 Wide-Arbor Basket

Potential targets known to be avoided

Excitatory or Inhibitory

none known

Oscillation Phase Locking