CA3 Radiatum
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (i)03000 Radiatum S101302:Ivy/Neurogliaform Family:Ivy/Neurogliaform:CA3

Name derivation
This simple and compact name captures the presence of axons and dendrites all in SR. CA3 distinguishes these cells from R cells in other subregions.

Synonym(s)
CA3 Ca-BP-immunoreactive non-pyramidal cell
CA3 Ca-BP-positive non-pyramidal cell in stratum radiatum
CA3 CaBP-positive neuron
CA3 CB-IR cell
CA3 CB-IR interneuron
CA3 CB-positive interneuron
CA3 radiatum cell
CA3 RC
CA3 type I CB-containing interneuron
CA3 type I CB-IR cell

List of articles
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Gulyas AI  (1996) Hippocampus
Pyramidal cell dendrites are the primary targets of calbindin D28k-immunoreactive interneurons in the hippocampus.
Gulyas AI, Freund TF.
Hippocampus, 1996, 6 (5), Pages: 525 - 534
PMID: 8953305; DOI: 10.1002/(SICI)1098-1063(1996)6:5<525::AID-HIPO5>3.0.CO;2-H
Tags: morphology, marker, connectivity, synapse probabilities
Hajos N  (2004) J Neurosci
Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro.
Hajos N, Palhalmi J, Mann EO, Nemeth B, Paulsen O, Freund TF.
J Neurosci, 2004 Oct 13, 24 (41), Pages: 9127 - 9137
PMID: 15483131; DOI: 10.1523/JNEUROSCI.2113-04.2004
Tags: morphology, connectivity, synapse probabilities
Toth K  (1992) Neuroscience
Calbindin D28k-containing nonpyramidal cells in the rat hippocampus: their immunoreactivity for GABA and projection to the medial septum.
Toth K, Freund TF.
Neuroscience, 1992 Aug, 49 (4), Pages: 793 - 805
PMID: 1279455; DOI: 10.1016/0306-4522(92)90357-8
Tags: morphology, marker
Tricoire L  (2011) J Neurosci
A blueprint for the spatiotemporal origins of mouse hippocampal interneuron diversity.
Tricoire L, Pelkey KA, Erkkila BE, Jeffries BW, Yuan X, McBain CJ.
J Neurosci, 2011 Jul 27, 31 (30), Pages: 10948 - 10970
PMID: 21795545; DOI: 10.1523/JNEUROSCI.0323-11.2011
Tags: marker, synapse probabilities

Supplemental PMIDs
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List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Ascoli
  • McBain

    • Morphology
    Soma
    CA3:SR
    Axons
    CA3:SR
    Dendrites
    CA3:SR

    Representative figure
    Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro.
    Hajos N, Palhalmi J, Mann EO, Nemeth B, Paulsen O, Freund TF
    J Neurosci, 2004 Oct 13, 24 (41), pages: 9127 - 9137
    PMID: 15483131; DOI: 10.1523/JNEUROSCI.2113-04.2004


    "Figure 5. ... Camera lucida reconstructions of an OLM [oriens lacunosum-moleculare] [CA3] cell (A), a radiatum cell {CA3 Radiatum} (B), and an RLM [radiatum-lacunosum moleculare] cell {CA3 R-LM} (C) are shown. ... B, The dendritic tree, as well as the axon cloud of the radiatum cell, were located in the stratum radiatum. C, The RLM cell with the majority of dendrites in the stratum radiatum exclusively projected to the stratum lacunosum-moleculare."


    Molecular markers
    Positive
    CB
    CB1 (confirmed by inference)
    CCK (multiple confirming inferences)
    CoupTF II
    nNOS
    NPY
    Negative
    5HT-3
    AR-beta1 (inference)
    AR-beta2 (multiple confirming inferences)
    CR (confirmed by inference)
    ENK
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (multiple confirming inferences)
    mGluR1a (inference)
    PV (confirmed by inference)
    SATB1 (inference)
    SOM (confirmed by inference)
    vGluT3
    VIP (confirmed by inference)
    Mixed expression
    None known

    Electrophysiological properties
    None known

    Notes
    This cell type is a result of a merger between CA3 03000 R and CA3 03000 calbindin. Notes on CA3 03000 calbindin: - Gulyas 1996 text states: "axons, at least the reconstructed sections, were [restricted to SR]," so they may be incomplete. Their evidence is based on six serially-reconstructed sections of 80 microm each. This is sufficient, and the cell type (as in all other cases) is based on the evidence available to us. - Other CA3 calbindin cell types exist: CA3 02200 calbindin and CA3 00003 calbindin Electrophysiology information is available for CA3 03000 radiatum cells and chemical marker information is available for CA3 03000 calbindin cells. However, since there is no apparent overlap, there is no basis for the creation of subtypes within our framework at this point.

    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    DG HIPROM
    CA3 Pyramidal
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Bistratified
    CA3 Ivy
    CA3 LMR-Targeting
    CA3 Lucidum ORAX
    CA3 Lucidum-Radiatum
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 O-LM
    CA3 Interneuron Specific Oriens
    CA3 Perforant Path-Associated Projecting*
    CA3 Interneuron Specific Quad
    CA3 Radiatum
    CA3 Trilaminar
    CA2 Pyramidal
    CA1 Back-Projection

    Potential sources known to be avoided
    Excitatory or Inhibitory
    none known

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    CA3 Pyramidal

    Potential targets
    Excitatory or Inhibitory
    CA3 Athorny Pyramidal*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Giant
    CA3 Granule
    CA3 Axo-axonic
    CA3 Basket
    CA3 Basket CCK+
    CA3 Mossy Fiber-Associated Basket CCK+*
    CA3 Bistratified
    CA3 Ivy
    CA3 LMR-Targeting
    CA3 Lucidum LAX
    CA3 Lucidum ORAX
    CA3 Lucidum-Radiatum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 Perforant Path-Associated*
    CA3 Perforant Path-Associated Projecting*
    CA3 Interneuron Specific Quad
    CA3 QuadD-LM
    CA3 Radiatum
    CA3 R-LM

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value