CA3 SO-SO
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (i)00003 SO-SO S131502:Collateral-related:RO-targeting:CA3

Name derivation
This straightforward name derives from the literature-based CA1 SO-SO. CA3 distinguishes these cells from SO-SO cells in other subregions. SO-SO stands for "Stratum Oriens (dendrites) - Stratum Oriens (axons)."

Synonym(s)
CA3 CaBP immunoreactive nonpyramidal cell
CA3 CaBP-immunoreactive non-pyramidal cell
CA3 CaBP-positive neuron
CA3 calbindin D28k (CB)-immunoreactive nonprincipal neuron
CA3 CB-positive interneuron
CA3 type II cell

List of articles
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Gulyas AI  (1996) Hippocampus
Pyramidal cell dendrites are the primary targets of calbindin D28k-immunoreactive interneurons in the hippocampus.
Gulyas AI, Freund TF.
Hippocampus, 1996, 6 (5), Pages: 525 - 534
PMID: 8953305; DOI: 10.1002/(SICI)1098-1063(1996)6:5<525::AID-HIPO5>3.0.CO;2-H
Tags: morphology, marker, connectivity, synapse probabilities
Hajos N  (2013) J Neurosci
Input-output features of anatomically identified CA3 neurons during hippocampal sharp wave/ripple oscillation in vitro.
Hajos N, Karlocai MR, Nemeth B, Ulbert I, Monyer H, Szabo G, Erdelyi F, Freund TF, Gulyas AI.
J Neurosci, 2013 Jul, 33 (28), Pages: 11677 - 11691
PMID: 23843535; DOI: 10.1523/JNEUROSCI.5729-12.2013
Tags: synapse probabilities
Toth K  (1992) Neuroscience
Calbindin D28k-containing nonpyramidal cells in the rat hippocampus: their immunoreactivity for GABA and projection to the medial septum.
Toth K, Freund TF.
Neuroscience, 1992 Aug, 49 (4), Pages: 793 - 805
PMID: 1279455; DOI: 10.1016/0306-4522(92)90357-8
Tags: morphology, marker

Supplemental PMIDs
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Morphology
Soma
CA3:SO
Axons
CA3:SO
Dendrites
CA3:SO

Molecular markers
Positive
AR-beta1 (inference)
CB
Negative
AR-beta2 (inference)
CR (multiple confirming inferences)
GABAa\alpha 6 (inference)
Gaba-a-alpha (multiple confirming inferences)
NPY (inference)
PV (multiple confirming inferences)
VIP (inference)
Mixed expression
None known

Electrophysiological properties
None known

Notes
Axonal evidence is a little bit weak; they were myelinated and disappeared into white matter towards the fimbria. Target is likely the medial septum. Other CA3 calbindin cell types exist: - CA3 03000 calbindin - CA3 02200 calbindin

Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG HIPROM
CA3 Pyramidal
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Bistratified
CA3 Ivy
CA3 Lucidum ORAX
CA3 O-LM
CA3 Interneuron Specific Oriens
CA3 Interneuron Specific Quad
CA3 SO-SO
CA3 Trilaminar
CA2 Pyramidal
CA1 Back-Projection

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
CA3 Pyramidal
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Axo-axonic
CA3 Horizontal Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Horizontal Basket CCK+*
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Mossy Fiber-Associated ORDEN
CA3 O-LM
CA3 Recurrent O-LM*
CA3 Interneuron Specific Oriens
CA3 Interneuron Specific Quad
CA3 QuadD-LM
CA3 SO-SO
CA3 Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value