CA3 Interneuron Specific Oriens
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (i)01113 Interneuron Specific Oriens S091202:Interneuron Specific:IS:CA3

Name derivation
This cell is verified to preferentially target non-principal cells. Although more politically loaded, the phrase "interneuron specific" is more compact than "non-principal cell-specific" and is more commonly found in the cited literature. "Oriens" describes the lcoation of the soma and axons. CA3 distinguishes these cells from interneuron specific cells in other subregions.

Synonym(s)
CA3 interneuron-selective cell
CA3 IS cell

List of articles
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Hajos N  (2004) J Neurosci
Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro.
Hajos N, Palhalmi J, Mann EO, Nemeth B, Paulsen O, Freund TF.
J Neurosci, 2004 Oct 13, 24 (41), Pages: 9127 - 9137
PMID: 15483131; DOI: 10.1523/JNEUROSCI.2113-04.2004
Tags: morphology, connectivity, synapse probabilities


Morphology
Soma
CA3:SO
Axons
CA3:SR
CA3:SL
CA3:SP
CA3:SO
Dendrites
CA3:SO

Representative figure
Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro.
Hajos N, Palhalmi J, Mann EO, Nemeth B, Paulsen O, Freund TF
J Neurosci, 2004 Oct 13, 24 (41), pages: 9127 - 9137
PMID: 15483131; DOI: 10.1523/JNEUROSCI.2113-04.2004


"Figure 6. Firing of [CA3] IS [interneuron-selective] cells {CA3 Interneuron Specific Oriens} is tightly coupled to gamma oscillation. A-C, Light microscopic reconstruction of two intracellularly filled putative IS cells. The cell bodies and the dendritic arbors for both neurons were found in the stratum oriens (A). The main axon originating from the somata gave rise to several collaterals predominantly arborizing in strata oriens and radiatum. Long axon branches reaching the CA3c region as well as penetrating into the CA1 were often decorated by drumstick-like boutons (B, arrows), whereas other varicose collaterals formed multiple appositions (arrows) with nonpyramidal cell bodies in the strata oriens or radiatum (C)"


Molecular markers
Positive
None known
Negative
GABAa\alpha 6 (inference)
Mixed expression
None known

Electrophysiological properties
None known

Notes
Merger with CA3 trilaminar 01113 rejected because of the lack of axonal presence in CA1 and Sub for these neurons.

Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG HIPROM
CA3 Pyramidal
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Bistratified
CA3 Ivy
CA3 Lucidum ORAX
CA3 O-LM
CA3 Interneuron Specific Oriens
CA3 Interneuron Specific Quad
CA3 SO-SO
CA3 Trilaminar
CA2 Pyramidal
CA1 Back-Projection

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
CA3 Axo-axonic
CA3 Horizontal Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Horizontal Basket CCK+*
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Bilayer Ivy*
CA3 LMR-Targeting
CA3 Lucidum*
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 O-LM
CA3 Recurrent O-LM*
CA3 Interneuron Specific Oriens
CA3 Perforant Path-Associated*
CA3 Perforant Path-Associated Projecting*
CA3 Interneuron Specific Quad
CA3 QuadD-LM
CA3 Radiatum
CA3 R-LM
CA3 SO-SO
CA3 Trilaminar
CA2 Wide-Arbor Basket

Potential targets known to be avoided
Excitatory or Inhibitory
CA3 Pyramidal
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Giant
CA3 Granule

Oscillation Phase Locking
Category
Value